Claudette Bardin

Persistent maternal anxiety affects the interaction between mothers and their very low birthweight children at 24 months.

BACKGROUND Parental distress following the birth of a premature infant diminishes the parents ability to be sensitive to the infants cues, and this may affect infant developmental outcomes. AIMS The present study examined the effects of maternal anxiety during infant hospitalization in the Neonatal Intensive Care Unit (NICU) on the interactive behavior of mothers with their very low birthweight (VLBW) children in toddlerhood. SUBJECTS A sample of 56 mothers and their VLBW infants were recruited in the NICU. STUDY DESIGN During the infants NICU stay, mothers completed a self-report measure of trait anxiety. These mothers and their infants were followed when the infants were 24 months corrected age, when mothers and their children were videotaped during free play at home. These videotapes were then coded using the Emotional Availability Scales. RESULTS Maternal anxiety was not found to be related to severity of neonatal illness. Maternal anxiety in the NICU was associated with less sensitivity and less structure in interaction with their toddlers at 24 months corrected age, even controlling for maternal education and child birthweight. Children of mothers with higher anxiety scores in the NICU were less likely to involve their mothers in their play at 24 months corrected age. CONCLUSIONS Maternal anxiety in the NICU predicted adverse interactive behaviors when the children were 24 months corrected age. Early identification of anxious mothers in the NICU is needed in order to initiate preventive intervention to support the mother-infant relationship.

Early maternal anxiety predicts cognitive and behavioural outcomes of VLBW children at 24 months corrected age

Aim:  The present study examined the effects of maternal anxiety during infant hospitalization in the Neonatal Intensive Care Unit (NICU) on the child’s cognitive and behavioural development at 24 months corrected age. Parental anxiety following the birth of a very low birthweight (VLBW, <1500 g) infant may impede their capacity to be sensitive to the infant’s cues and adversely affect infant developmental outcomes.

Lissencephaly with der(17)t(17;20)(p13.3;p12.2)mat

The isolated lissencephaly sequence may be caused by point mutations of the LIS1 gene or by FISH‐detectable microdeletions of the 17p13.3 region, which carries the LIS1 gene. These have various patterns of phenotypic presentations, including the Miller–Dieker syndrome (MDS). Approximately 20% of these deletions are associated with a derivative chromosome 17 inherited from a parent who has a balanced reciprocal translocation involving chromosome 17 and another chromosome. We report a case of lissencephaly associated with a maternally inherited unbalanced translocation involving chromosome arms 17p and 20p. This results in partial monosomy of 17p13.3→pter and partial trisomy of 20p12.2→pter. To our knowledge, this is the first report of a reciprocal translocation between 17p and 20p. Our patient has a combination of findings of the MDS and trisomy 20p, along with several unique anomalies not described in either of those two conditions. This report may contribute to the delineation of a phenotype resulting from partial monosomy 17p and partial trisomy of 20p.

THE FIRST 2 YEARS OF LIFE OF SGA INFANTS BORN <28 WEEKS OF GESTATION. A CASE-CONTROL STUDY. 1129

THE FIRST 2 YEARS OF LIFE OF SGA INFANTS BORN <28 WEEKS OF GESTATION. A CASE-CONTROL STUDY. 1129

The Impact of Fetal Growth Restriction and Multiple Gestation on Perinatal Outcomes Before 28 Weeks of Gestation

The Impact of Fetal Growth Restriction and Multiple Gestation on Perinatal Outcomes Before 28 Weeks of Gestation

Comparison of Risks from Percutaneous Central Venous Catheters (PCVC) and Peripheral Lines in ELBW Infants: A Cohort Controlled Study

Comparison of Risks from Percutaneous Central Venous Catheters (PCVC) and Peripheral Lines in ELBW Infants: A Cohort Controlled Study

Metabolic and Serum Electrolyte Abnormalities in Very Low Birth Weight (VLBW) Premature Newborns. 1633

Renal function in the VLBW is substantially immature relative to the term and more mature preterm neonates leading to significant fluid, electrolyte and metabolic derangements. In order to determine the magnitude of these problems in the VLBW, the clinical course in the immediate neonatal period (first 4 wks of life) of all 145 preterm neonates admitted to our neonatal intensive care unit with birth weights 7.0 mmol/L), 89/145 (61.4%) had hyponatremia (Na 150 mmol/L). 106/145 (73.1%) had at least one episode of hyperglycemia (serum glucose >8.0 mmol/L). 49/145(33.8%) required insulin for the hyperglycemia except one who had insulin for hyperkalemia. 24 babies (16.6%) had renal failure (urine flow rate <0.5 ml/kg/h) with the mean onset at 15.6±12.6 days. Maximum blood urea nitrogen was 14.7±4.6 mmol/L (range: 4.3-26.4 mmol/L) and maximum serum creatinine was 242±73 μmol/L (range 126-405 μmol/L). Drugs used in these babies included furosemide, ethacrynic acid and indomethacin. Data show that significant metabolic and electrolyte derangements occur commonly in VLBW neonates underlining the need for close surveillance and monitoring and further studies on renal function in this population.

NEONATAL AND MATERNAL OUTCOME OF AN EARLY DISCHARGE PROGRAM IN A LARGE MULTICULTURAL POPULATION. 1233

NEONATAL AND MATERNAL OUTCOME OF AN EARLY DISCHARGE PROGRAM IN A LARGE MULTICULTURAL POPULATION. 1233