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Claudine Scolaro

École Polytechnique Fédérale de Lausanne

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Publication

Featured researches published by Claudine Scolaro.

Journal of Inorganic Biochemistry | 2008

Hydrolysis study of the bifunctional antitumour compound RAPTA-C, [Ru(η6-p-cymene)Cl2(pta)]

Claudine Scolaro; Christian G. Hartinger; Claire S. Allardyce; Bernhard K. Keppler; Paul J. Dyson

The hydrolysis of [Ru(eta(6)-p-cymene)Cl(2)(PTA)] (PTA=1,3,5-triaza-7-phosphatricyclo-[3.3.1.1]decanephosphine; RAPTA-C) was studied using UV-visible (UV-vis) spectrophotometry and NMR spectroscopy. In analogy to in silico studies, [Ru(eta(6)-p-cymene)Cl(H(2)O)(PTA)](+) was found to be the most abundant hydrolysis product, although the dihydrolysed species [Ru(eta(6)-p-cymene)(OH)(H(2)O)(PTA)](+) and the dichloro compound are present. Rate constants for the different aquation and anation steps and the equilibrium constants were determined. Hydrolysis is suppressed at high chloride concentrations. These results have important implications on the mode of action of the RAPTA drug candidates.

Journal of Medicinal Chemistry | 2005

In Vitro and in Vivo Evaluation of Ruthenium(II)−Arene PTA Complexes

Claudine Scolaro; Alberta Bergamo; Laura Brescacin; Riccarda Delfino; Moreno Cocchietto; Gábor Laurenczy; Tilmann J. Geldbach; Gianni Sava; Paul J. Dyson

Applied Organometallic Chemistry | 2005

Development of organometallic (organo-transition metal) pharmaceuticals†

Claire S. Allardyce; Antoine Dorcier; Claudine Scolaro; Paul J. Dyson

Inorganic Chemistry | 2006

Development of organometallic ruthenium-arene anticancer drugs that resist hydrolysis.

Wee Han Ang; Elisa Daldini; Claudine Scolaro; Rosario Scopelliti; Lucienne Juillerat-Jeannerat; Paul J. Dyson

Journal of Medicinal Chemistry | 2007

Development of Ruthenium Antitumor Drugs that Overcome Multidrug Resistance Mechanisms

Carsten A. Vock; Wee Han Ang; Claudine Scolaro; Andrew D. Phillips; Lucienne Lagopoulos; Lucienne Juillerat-Jeanneret; Gianni Sava; Rosario Scopelliti; Paul J. Dyson

Organometallics | 2006

Influence of Hydrogen-Bonding Substituents on the Cytotoxicity of RAPTA Compounds

Claudine Scolaro; Tilmann J. Geldbach; Sébastien Rochat; Antoine Dorcier; Christian Gossens; Alberta Bergamo; Moreno Cocchietto; Ivano Tavernelli; Gianni Sava; Ursula Rothlisberger; Paul J. Dyson

Journal of Medicinal Chemistry | 2006

Synthesis, Characterization, and in Vitro Evaluation of Novel Ruthenium(II) η6-Arene Imidazole Complexes

Carsten A. Vock; Claudine Scolaro; Andrew D. Phillips; Rosario Scopelliti; Gianni Sava; Paul J. Dyson

Dalton Transactions | 2007

Tuning the hydrophobicity of ruthenium(II)–arene (RAPTA) drugs to modify uptake, biomolecular interactions and efficacy

Claudine Scolaro; Adrian B. Chaplin; Christian G. Hartinger; Alberta Bergamo; Moreno Cocchietto; Bernhard K. Keppler; Gianni Sava; Paul J. Dyson

European Journal of Inorganic Chemistry | 2005

Is the Aromatic Fragment of Piano‐Stool Ruthenium Compounds an Essential Feature for Anticancer Activity? The Development of New RuII‐[9]aneS3 Analogues

Barbara Serli; Ennio Zangrando; Teresa Gianferrara; Claudine Scolaro; Paul J. Dyson; Alberta Bergamo; Enzo Alessio

Organometallics | 2008

Importance of the p-Ligand: Remarkable Effect of the Cyclopentadienyl Ring on the Cytotoxicity of Ruthenium PTA Compounds

Barnali Dutta; Claudine Scolaro; Rosario Scopelliti; Paul J. Dyson; Kay Severin

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Paul J. Dyson

École Polytechnique Fédérale de Lausanne

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Alberta Bergamo

University of Trieste

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Gianni Sava

University of Trieste

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Rosario Scopelliti

École Polytechnique Fédérale de Lausanne

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Barbara Serli

University of Trieste

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Ennio Zangrando

University of Trieste

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Enzo Alessio

University of Trieste

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Teresa Gianferrara

University of Trieste

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Christian G. Hartinger

University of Auckland

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Bernhard K. Keppler

University of Vienna

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