Claudio Dora

Acetabular rim degeneration: a constant finding in the aged hip.

During recent years the acetabular labrum has gained increased interest because its degeneration frequently is found in association with early osteoarthritis of the hip. To determine spatial distribution of labral degeneration in the aged hip and to identify the pathologic features triggering this event, an anatomic postmortem and an intraoperative in vivo study were done in 30 cadavers (range, 60–90 years) and in 18 elderly patients (range, 69–97 years) who had hemiarthroplasty for displaced femoral neck fractures. In both groups, no gross anatomic or radiographic abnormalities suggesting advanced osteoarthritis were present. All cadaveric acetabuli (30 of 30) revealed labrum and cartilage damage. Labrum damage (17 of 18) and cartilage lesions (16 of 18) occurred less frequently and were smaller in the elderly patients. Peripheral joint degeneration was most frequent at the superior acetabular rim close to the anterior inferior iliac spine. More centrally localized cartilage lesions were present in 47% of cadavers and in 28% of patients. The majority of femurs (cadavers) (80%) showed reduced narrowing at the anteromedial femoral head-neck junction causing impingement against the corresponding acetabular rim or squeezing of this area into the joint during flexion, whereas the femoral head cartilage appeared normal in all but one hip. Acetabular rim degeneration is a constant finding in the aged hip, which seems to be triggered by femoroacetabular impingement.

MR arthrography of acetabular cartilage delamination in femoroacetabular cam impingement.

PURPOSE To retrospectively assess the frequency and performance of magnetic resonance (MR) arthrography to help diagnose acetabular cartilage delamination in femoroacetabular impingement (FAI). MATERIALS AND METHODS Institutional review board approval and informed consent were waived for this retrospective study. Forty-four consecutive patients with FAI of the cam type were included (mean age, 30.7 years; range, 16-49 years), including 30 men (mean age, 30.5 years; range, 16-49 years) and 14 women (mean age, 31.4 years; range, 18-48 years). The inclusion criteria were no previous surgery, surgery within 3 months after MR imaging, and availability of a detailed surgical report with acetabular cartilage findings. MR arthrographic findings were assessed independently by two blinded readers. Findings at surgery served as reference standard. Sensitivity, specificity, accuracy, and kappa statistics for interobserver agreement were calculated. RESULTS At surgery, acetabular cartilage delamination was seen in 23 (52%) of 44 patients (mean size of cartilage flap from acetabular rim, 7.6 mm; range, 2-30 mm). At MR, patients with fluid signal intensity under the cartilage delamination had a respective sensitivity, specificity, and accuracy of 22%, 95%, and 57% for reader 1 and 30%, 95%, and 61% for reader 2. A hypointense line in the acetabular cartilage on sagittal three-dimensional double-echo steady-state images with water excitation demonstrated moderate diagnostic performance (respective sensitivity, specificity, and accuracy were 70%, 57%, and 64% for reader 1 and 70%, 62%, and 66% for reader 2). Hypointense areas in the acetabular cartilage were quite specific on both coronal intermediate-weighted fat-saturated images (respective sensitivity, specificity, and accuracy were 52%, 90%, and 70% for reader 1 and 74%, 90%, and 82% for reader 2) and coronal T1-weighted images (respective sensitivity, specificity, and accuracy were 35%, 90%, and 61% for reader 1 and 61%, 95%, and 77% for reader 2). CONCLUSION Cartilage delamination is common in patients undergoing surgery for FAI. Fluid under the cartilage delamination is a specific but rare finding. Hypointense areas in the acetabular cartilage seen on intermediate-weighted fat-saturated or T1-weighted images appear to be helpful diagnostic criteria.

Entry Point Soft Tissue Damage in Antegrade Femoral Nailing: A Cadaver Study

Introduction Little attention is paid to insertion site morbidity associated with antegrade femoral nailing. However, residual peritrochanteric pain after nailing is not uncommon. Additionally, the end branches of the medial femoral circumflex artery (m.f.c.a.) supplying the femoral head are in close proximity to the insertion site of the nail, and the occurrence of avascular necrosis of the femoral epiphysis after nailing in adolescents is rather frequent. Objective The aim of this study was to assess iatrogenic soft tissue injuries at the site of nail insertion. Materials and Methods Nailing with a reamed AO universal femoral nail was performed on sixteen adult cadavers followed by dissection of the proximal part of the femur to assess possible damage to the soft tissues. Three entry portals were defined. (A) entry portal lateral to the junction of the neck and the greater trochanter; (B) entry portal at the base of the greater trochanter anterior to a line along the longitudinal axis of the femoral neck; and (C) entry portal at the base of the greater trochanter posterior to a line along the axis of the femoral neck (at the piriformis fossa). Results In Group A, partial avulsion of the piriformis and the obturator internus tendon were present in four and in one of five specimens, respectively. Group B showed injuries to the piriformis tendon in two and to the gluteus minimus tendon in one of four cases. In Group C, partial avulsion of the piriformis, obturator internus, and obturator externus tendon were encountered in five, six, and two of seven specimens, respectively. Anterior branches of the ramus profundus of the m.f.c.a. within the synovial fold were damaged in all of these cases. Conclusion To select the best nail entry portal, the ease of nail insertion must be weighed against the resulting soft tissue damage at the site of insertion. The nail entry portal at the piriformis fossa, although geometrically ideal and most recommended, causes the most significant damage to muscle and tendons as well as to the blood supply to the femoral head. Therefore, even if reported only once, the occurrence of avascular necrosis of the femoral head after nailing in adults is a possible complication of this nail entry portal. The authors therefore prefer to avoid this entry portal in every case. The nail entry portal anterior to the longitudinal axis of the femoral neck, as in group B, although better with respect to the soft tissue damage, has the worst geometric and biomechanical disadvantages. The results of the current study favor the nail entry portal lateral at the greater trochanter as in Group A, which is equal to the entry portal B with respect to the soft tissue damage but allows introduction of the nail into the medullar cavity without difficulties.

Retroversion of the acetabular dome after Salter and triple pelvic osteotomy for congenital dislocation of the hip.

Retroversion of the acetabular dome has been associated with hip pain and osteoarthritis in several studies. Nevertheless, this acetabular alignment received little attention when studying the radiological outcome of pelvic osteotomies in childhood. We therefore reviewed the charts and X-rays of 73 patients with congenital dislocations, who underwent 97 pelvic osteotomies in childhood. We focussed our attention on anterior overcoverage or retroversion of the acetabular dome, respectively. Eighty-six Salter and 11 LeCoeur osteotomies were performed on patients with a mean age of 4.8 years. The mean age at last X-ray documentation was 16.5 years. The version of the acetabular dome was estimated qualitatively from the relationship of the anterior and posterior border to each other and measured semiquantitatively using templates developed by Hefti. According to Lequesnes criteria 94% of the hips were normal or borderline at maturity. A retroverted acetabular dome was present in 27% and averaged −15°. It was more frequent (60% versus 24%) and more pronounced (−16° versus +5°) after Le Coeurs than after Salters osteotomy and in the residually dysplastic hips (83% versus 22%; −15° versus +3°). It is suggested that anterior overcoverage of the femoral head results from ignorance, when choosing the type and performing the pelvic osteotomy, of where coverage needs to be improved in an individual hip. We question the long-term outcome of these hips because such rotational misalignment has been suggested to be associated with early hip pain and osteoarthritis. In order to avoid such misalignment, preoperative evaluation of where coverage needs to be improved in an individual hip and efforts for better intraoperative control of acetabular reorientation should be made.

Soft-tissue changes in hip abductor muscles and tendons after total hip replacement: COMPARISON BETWEEN THE DIRECT ANTERIOR AND THE TRANSGLUTEAL APPROACHES

The direct anterior approach in total hip replacement anatomically offers the chance to minimise soft-tissue trauma because an intermuscular and internervous plane is explored. This motivated us to abandon our previously used transgluteal approach and to adopt the direct anterior approach for total hip replacement. Using MRI, we performed a retrospective comparative study of the direct anterior approach with the transgluteal approach. There were 25 patients in each group. At one year post-operatively all the patients underwent MRI of their replaced hips. A radiologist graded the changes in the soft-tissue signals in the abductor muscles. The groups were similar in terms of age, gender, body mass index, complexity of the reconstruction and absence of symptoms. Detachment of the abductor insertion, partial tears and tendonitis of gluteus medius and minimus, the presence of peri-trochanteric bursal fluid and fatty atrophy of gluteus medius and minimus were significantly less pronounced and less frequent when the direct anterior approach was used. There was no significant difference in the findings regarding tensor fascia lata between the two approaches. We conclude that use of the direct anterior approach results in a better soft-tissue response as assessed by MRI after total hip replacement. However, the impact on outcome needs to be evaluated further.

Improved degradation and bioactivity of amorphous aerosol derived tricalcium phosphate nanoparticles in poly(lactide-co-glycolide)

The industrially used flame synthesis of silica polymer fillers was extended to amorphous tricalcium phosphate (a-TCP) nanoparticles and resulted in a similar morphology as the traditionally used polymer fillers. Doping of poly(lactide-co-glycolide) (PLGA) with such highly agglomerated a-TCP was investigated for mechanical properties, increased in vitro biodegradation and the formation of a hydroxyapatite layer on the surface of the nanocomposite. PLGA films with particle loadings ranging from 0 to 30 wt% were prepared by solvent casting. Degradation in simulated body fluid (SBF) at 37 °C under sterile conditions for up to 42 days was followed by Raman spectroscopy, scanning electron microscopy (SEM), thermal analysis and tensile tests. The presence of nanoparticles in the PLGA matrix slightly increased the Youngs modulus up to 30% compared to pure polymer reference materials. The nanoparticle doped films showed a significantly increased loss of polymer mass during degradation. Scanning electron microscopy images of doped films showed that the SBF degraded the PLGA by corrosion as facilitated by the incorporation of nanoparticulate calcium phosphate. Raman spectroscopy revealed that the deposition of about 10 nm sized hydroxyapatite crystallites on the surface of doped PLGA films was strongly increased by the addition of tricalcium phosphate fillers. The combination of increased hydroxyapatite formation and enhanced polymer degradation may suggest the use of such amorphous, aerosol derived a-TCP fillers for applications in non-load-bearing implant sites.

Pathomorphologic characteristics of posttraumatic acetabular dysplasia

OBJECTIVES The pathomorphology of posttraumatic acetabular dysplasia differs fundamentally from the classic developmental dysplasia of the adolescent. The aim of this report is to qualify and quantify the pathomorphologic characteristics of the posttraumatic acetabular dysplasia and to define the requirements for adequate corrective surgery in this type of dysplasia. DESIGN AND MATERIAL Retrospective review of the anteroposterior (AP) radiographs of ten patients with symptomatic posttraumatic acetabular dysplasia. In five cases, false profile views and in five cases computed tomography (CT) scans were also available for investigation. Measurements of distances and angles on radiographs and CT scans were made by pencil and goniometer. RESULTS On the AP radiographs, posttraumatic acetabular dysplasia shows uniformly deformed true pelvis with an angular deformation of the innominate bone averaging 20 degrees in the region of the acetabular fossa that causes the concavity of the pelvic brim to increase in direction of the involved acetabulum and creates both a lateral and a caudal displacement of the acetabulum, averaging twenty-three millimeters and nine millimeters, respectively. The increased width of the inner wall of the acetabulum, measuring an average of eleven millimeters, makes lateralization of the center of the femoral head reach a mean of forty-three millimeters. The acetabular deformity in all cases shows a pronounced lateral deficiency. Ventral deficiency is moderate. All ten posttraumatic dysplastic acetabuli show marked retroversion averaging 27 degrees. In contrast, the contralateral acetabuli shows a mean anteversion of 23 degrees. CONCLUSIONS The morphology of this kind of acetabular dysplasia is uniform and differs significantly from that seen in classic developmental dysplasia of the hip. For reconstructive surgery of such a hip, the challenge to abolish the lateralization of the hip joint to restore normal body weight lever arm is imperative. Because acetabular retroversion is a reproductive feature of posttraumatic dysplasia, it is important to avoid further reduction of the posterolateral containment of the femoral head and augmentation of the anterior acetabular wall, increasing the risk of anterior impingement.

Hip MRI: How Useful Is Intraarticular Contrast Material for Evaluating Surgically Proven Lesions of the Labrum and Articular Cartilage?

OBJECTIVE The objective of our study was to prospectively compare the diagnostic performance of MR arthrography and conventional MRI with surgical correlation in the same patient for detecting labrum and articular cartilage defects. SUBJECTS AND METHODS Twenty-eight patients (mean age, 31.8 years) underwent MR arthrography, conventional MRI, and subsequent hip surgery, which served as the reference standard. Labrum and cartilage defects were evaluated at MRI by two independent readers. A McNemar test and kappa statistics were used for statistical analysis. RESULTS At surgery, 31 labral tears were identified. MR arthrography had an advantage over conventional MRI for detecting labral tears at the anterosuperior quadrant (sensitivity of MR arthrography, 81% and 69% for readers 1 and 2, respectively; sensitivity of conventional MRI, 50% for both readers); this difference in performance between MR arthrography and conventional MRI was statistically significant for reader 1 (p = 0.02) but not for reader 2 (p = 0.2). Interobserver agreement for labral tears was higher for MR arthrography (κ = 0.81) than for conventional MRI (κ = 0.63). Surgery showed 31 acetabular cartilage defects and nine femoral cartilage defects. MR arthrography had an advantage over conventional MRI for detecting acetabular cartilage defects (sensitivity of MR arthrography, 71% and 92% for readers 1 and 2, respectively; sensitivity of conventional MRI, 58% and 83%), whereas there was no advantage to using MR arthrography for detecting femoral cartilage defects with statistically significant difference for the acetabular cartilage or femoral cartilage. Interobserver agreement was slightly higher for MR arthrography (κ = 0.50) than for conventional MRI (κ = 0.40) for assessing the acetabular cartilage and was almost identical for the femoral cartilage (κ = 0.62 and 0.63, respectively). CONCLUSION MR arthrography was superior to conventional MRI for detecting labral tears and acetabular cartilage defects and showed a higher interobserver agreement. For femoral cartilage lesions, both modalities yielded comparable results.

Adolescent slipped capital femoral epiphysis treated by a modified Dunn osteotomy with surgical hip dislocation

Between June 2001 and November 2008 a modified Dunn osteotomy with a surgical hip dislocation was performed in 30 hips in 28 patients with slipped capital femoral epiphysis. Complications and clinical and radiological outcomes after a mean follow-up of 3.8 years (1.0 to 8.5) were documented. Subjective outcome was assessed using the Harris hip score and the Western Ontario and McMaster Universities osteoarthritis index questionnaire. Anatomical or near-anatomical reduction was achieved in all cases. The epiphysis in one hip showed no perfusion intra-operatively and developed avascular necrosis. There was an excellent outcome in 28 hips. Failure of the implants with a need for revision surgery occurred in four hips. Anatomical reduction can be achieved by this technique, with a low risk of avascular necrosis. Cautious follow-up is necessary in order to avoid implant failure.

Late repair of abductor avulsion after the transgluteal approach for hip arthroplasty

The abductor release sometimes does not heal after a transgluteal approach for hip arthroplasty. Factors influencing the success of subsequent repair are unclear. We used magnetic resonance imaging (MRI) to compare the condition of the gluteus medius with clinical outcome after late repair of abductor dehiscence in 12 total hip patients. Evaluation included a pain rating, gait evaluation, Trendelenburg test, strength grading, and Harris Hip Score. Most had both prerepair and postrepair MRI studies to assess the repair and to grade abductor muscle fatty degeneration. Two repairs without MRI were explored surgically. Although average pain, limp, and strength scores improved significantly, rerupture occurred in 4 subjects and fatty degeneration in the gluteus medius did not improve, even with intact repair. Nine patients were satisfied; 7 of these had an intact repair. Magnetic resonance imaging and operative observations suggest that chronic degeneration in the abductor mechanism is the major impediment to successful repair.