Patrick O. Zingg

Clinical and structural outcomes of nonoperative management of massive rotator cuff tears.

BACKGROUND The natural history of massive rotator cuff tears is not well known. The purpose of this study was to determine the clinical and structural mid-term outcomes in a series of nonoperatively managed massive rotator cuff tears. METHODS Nineteen consecutive patients (twelve men and seven women; average age, sixty-four years) with a massive rotator cuff tear, documented by magnetic resonance imaging, were identified retrospectively. There were six complete tears of two rotator cuff tendons and thirteen complete tears of three rotator cuff tendons. All patients were managed exclusively with nonoperative means. Nonoperative management was chosen when a patient had low functional demands and relatively few symptoms and/or if he or she refused to have surgery. For the purpose of this study, patients were examined clinically and with standard radiographs and magnetic resonance imaging. RESULTS After a mean duration of follow-up of forty-eight months, the mean relative Constant score was 83% and the mean subjective shoulder value was 68%. The score for pain averaged 11.5 points on a 0 to 15-point visual analogue scale in which 15 points represented no pain. The active range of motion did not change over time. Forward flexion and abduction averaged 136 degrees; external rotation, 39 degrees; and internal rotation, 66 degrees. Glenohumeral osteoarthritis progressed (p = 0.014), the acromiohumeral distance decreased (p = 0.005), the size of the tendon tear increased (p = 0.003), and fatty infiltration increased by approximately one stage in all three muscles (p = 0.001). Patients with a three-tendon tear showed more progression of osteoarthritis (p = 0.01) than did patients with a two-tendon tear. Four of the eight rotator cuff tears that were graded as reparable at the time of the diagnosis became irreparable at the time of final follow-up. CONCLUSIONS Patients with a nonoperatively managed, moderately symptomatic massive rotator cuff tear can maintain satisfactory shoulder function for at least four years despite significant progression of degenerative structural joint changes. There is a risk of a reparable tear progressing to an irreparable tear within four years.

How Useful Is the Alpha Angle for Discriminating between Symptomatic Patients with Cam-type Femoroacetabular Impingement and Asymptomatic Volunteers?

PURPOSE To compare the alpha-angle measurements in volunteers and patients with femoroacetabular impingement (FAI) and to develop potential threshold values. MATERIALS AND METHODS This study was approved by the institutional review board; all individuals signed informed consent. Magnetic resonance (MR) images at 1.5 T in 106 individuals (ages 20-50 years) were analyzed in 53 patients (33 cam- and 20 mixed-type FAI) and 53 age- and sex-matched asymptomatic volunteers. Alpha angles were measured on radially reformatted MR images of the proximal femur by two independent readers. Intraclass correlation coefficient (ICC) and receiver operating characteristic (ROC) were calculated. RESULTS Mean alpha angles were highest in the anterosuperior segment: 65.4° ± 11.5 [standard deviation] and 65.2° ± 7.3 for readers 1 and 2 in patients and 53.3° ± 9.6 and 55.0° ± 8.8 in volunteers, respectively (P < .001, patients vs volunteers). Alpha angles greater than 55° were measured in 20 (38%) and 33 (62%) of 53 volunteers for readers 1 and 2, respectively. Maximal alpha angle in any segment was substantially different (P < .001) in patients and volunteers (70.3° ± 11.2 vs 57.9° ± 10.5 for reader 1; 69.4° ± 8.8 vs 58.7° ± 8.9 for reader 2), with a large overlap. Overall interobserver agreement was good (ICC, 0.712). ROC showed the largest area under the curve at the anterosuperior segment: 0.791 and 0.824 for readers 1 and 2, respectively (P < .001). A 55° alpha-angle threshold value gave a sensitivity and specificity of 81% and 65% for reader 1 and of 90% and 47% for reader 2, respectively. A 60° alpha-angle threshold value gave a sensitivity and specificity of 72% and 76% for reader 1 and 80% and 73% for reader 2, respectively. CONCLUSION There is substantial overlap in the alpha-angle measurements between volunteers and patients with cam-type deformities. Discrimination is best at the anterosuperior segment. Increasing the alpha-angle threshold value from 55° to 60° reduces false-positive results while maintaining a reasonable sensitivity.

Femoral Antetorsion: Comparing Asymptomatic Volunteers and Patients with Femoroacetabular Impingement

PURPOSE To assess the range of femoral antetorsion with magnetic resonance (MR) imaging in asymptomatic volunteers and patients with different subtypes of femoroacetabular impingement (FAI) because abnormal femoral antetorsion might be a contributing factor in the development of FAI. MATERIALS AND METHODS This study was institutional review board approved; all individuals provided signed informed consent. Sixty-three asymptomatic volunteers and 63 patients with symptomatic FAI between age 20 and 50 years were matched for age and sex. They underwent standard MR imaging with two additional rapid transverse sequences over the proximal and distal femur for antetorsion measurement. Twenty volunteers underwent a second MR imaging examination in the same leg. Two readers independently measured femoral antetorsion. The time for the additional sequences was tabulated. Interobserver agreement was calculated; differences in antetorsion were assessed by using analysis of variance and the unpaired t test. RESULTS Femoral antetorsion can be assessed with MR imaging in about 80 seconds, with high interobserver agreement (intraclass correlation coefficient [ICC] = 0.967) and high agreement between different MR examinations (ICC = 0.966). Women had a significantly larger antetorsion than men (P < .001 for both readers), and antetorsion of the left femur was significantly larger than that of the right femur (P = .01 for reader 1, P = .02 for reader 2). Overall, antetorsion was similar in volunteers and in patients for reader 1 (12.7° ± 10.0 [standard deviation] vs 12.6° ± 9.8, respectively; P = .9) and reader 2 (12.8° ± 10.1 vs 13.5° ± 9.8, respectively; P = .7). Femoral antetorsion was significantly higher in patients with pincer-type FAI than in those with cam-type FAI for reader 1 (18.3° ± 9.8 vs 10.0° ± 9.1, P = .02) and reader 2 (18.7° ± 10.5 vs 11.6° ± 8.8, P = .04). CONCLUSION Femoral antetorsion can be measured rapidly and with good reproducibility with MR imaging. Patients with pincer-type FAI had a significantly larger femoral antetorsion than patients with cam-type FAI.

Anterior minimally invasive approach for total hip replacement: five-year survivorship and learning curve

Opponents associate minimally invasive total hip replacement (THR) with additional risks, potentially resulting in increased implant failure rates. The purpose was to document complications, quality of implant positioning and five-year survivorship of THR using the AMIS approach and to test the hypothesis that eventual high complication and revision rates would be limited to an early series and be avoided by junior surgeons who get trained by a senior surgeon. A consecutive series of 150 primary THR implanted during the introduction of the AMIS technique in the department was retrospectively analysed for complications, implant positioning and implant survival after a minimum of five years. Survivorship curves of implants were compared between different surgeons and time periods. Due to implant revision for any reason the five-year survival rate was 94.6%, 78.9% for the first 20 and 96.8% for the following 130 AMIS procedures (p = 0.001). The hazard ratio for implant failure was 0.979 indicating a risk reduction of 2% every further case. The five-year implant survivorship of those procedures performed by two junior surgeons was 97.7%. We conclude that adoption of AMIS temporarily exposed patients to a higher risk of implant revisions, which normalised after the first 20 cases and that experience from a single surgeons learning curve could effectively be taught to junior surgeons.

Metatarsophalangeal joint arthrodesis after failed Keller-Brandes procedure.

Background: Keller-Brandes resection arthroplasty for correction of symptomatic hallux valgus deformity can obtain early good results, but late complications, such as recurrence of the deformity and instability of the first ray, have been described. Arthrodesis of the first metatarsophalangeal, (MTP) joint can be done as a salvage procedure. The aim of this prospective study was to evaluate the clinical outcome of the arthrodesis and its effect on the biomechanics of the first ray. Methods: Between October, 1999, and December, 2002, arthrodesis of the MTP joint was done after a failed Keller-Brandes procedure in 28 feet of 26 consecutive patients. Twenty patients (22 feet) with a minimum of 24 months followup were available for clinical and radiographic assessment. Pedobarographic measurements were obtained at latest followup in 16 patients (17 feet). Results: Sixteen feet (72%) were pain-free and six feet (28%) had mild, occasional pain. The American Orthopaedic Foot and Ankle Society (AOFAS) forefoot score increased from a preoperative 44 (range 29 to 67) points to 85 (range 73 to 90) points at longest clinical followup (average 34 months, range 23 to 48, p < 0.001). The average hallux valgus angle was corrected from 24.0 (range 7 to 47) degrees preoperatively to 16.0 (range 0 to 40) degrees postoperatively (p < 0.001). Two feet had pseudoarthroses. Biomechanically, the MTP joint arthrodesis could not fully restore the function of the hallux but produced a significant improvement, allowing a more physiologic loading pattern under the hallux and the metatarsal heads. Conclusions: First MTP joint arthrodesis after a failed Keller-Brandes procedure is a technically safe and reliable technique. It resulted in a marked reduction of pain and gain of function that produced high patient satisfaction.

Influence of Resection Geometry on Fracture Risk in the Treatment of Femoroacetabular Impingement A Finite Element Study

Background: A fracture is the most serious complication of surgical resection of the femoral head-neck junction in the treatment of cam-type femoroacetabular impingement (FAI). Purpose: To investigate the influence of resection length, width, and depth on postoperative fracture risk in activities of daily living. Study Design: Descriptive laboratory study. Methods: The femoral anatomy used for the finite element model was based upon a publicly available standardized model. For descriptive validation, the fracture location was compared with radiographs of patients who had suffered from a femoral neck fracture after surgical treatment of FAI in our institution. Additionally, a 2-part quantitative validation against previously published experimental data was performed. To simulate surgery, round resections were made in which length and width were varied at 10%, 20%, and 30%. The fracture loads were compared with published in vivo loads measured during activities of daily living with telemetric hip implants. Results: Validation showed that the model predicted fracture locations comparable with clinical cases and fracture loads within published experimental values. Femoral fracture loads were 325% more sensitive to resection deepening and 70% more sensitive to widening than lengthening. Conclusion: Although resection depth is the most important determinant of bone resistance, it should be considered in combination with resection length and width. Even a resection depth as low as 10% may lead to a fracture in case of stumbling. Clinical Relevance: We show that for resection depths of 20% or less and resection length of less than 35% of the femoral neck, normal activities of daily living are safe. Resection widths typically achieved in practice did not induce fractures during activities of daily living. Patients who have undergone surgical resection should be counseled on how to try to avoid stumbling.

Optimal length of cultivation time for isolation of Propionibacterium acnes in suspected bone and joint infections is more than 7 days

ABSTRACT Diagnosis of Propionibacterium acnes bone and joint infection is challenging due to the long cultivation time of up to 14 days. We retrospectively studied whether reducing the cultivation time to 7 days allows accurate diagnosis without losing sensitivity. We identified patients with at least one positive P. acnes sample between 2005 and 2015 and grouped them into “infection” and “no infection.” An infection was defined when at least two samples from the same case were positive. Clinical and microbiological data, including time to positivity for different cultivation methods, were recorded. We found 70 cases of proven P. acnes infection with a significant faster median time to positivity of 6 days (range, 2 to 11 days) compared to 9 days in 47 cases with P. acnes identified as a contamination (P < 0.0001). In 15 of 70 (21.4%) patients with an infection, tissue samples were positive after day 7 and in 6 patients (8.6%) after day 10 when a blind subculture of the thioglycolate broth was performed. The highest sensitivity was detected for thioglycolate broth (66.3%) and the best positive predictive values for anaerobic agar plates (96.5%). A prolonged transportation time from the operating theater to the microbiological laboratory did not influence time to positivity of P. acnes growth. By reducing the cultivation time to 7 days, false-negative diagnoses would increase by 21.4%; thus, we recommend that biopsy specimens from bone and joint infections be cultivated to detect P. acnes for 10 days with a blind subculture at the end.

Cost analysis of fresh-frozen femoral head allografts: is it worthwhile to run a bone bank?

To assess the sustainability of our institutional bone bank, we calculated the final product cost of fresh-frozen femoral head allografts and compared these costs with the use of commercial alternatives. Between 2007 and 2010 all quantifiable costs associated with allograft donor screening, harvesting, storage, and administration of femoral head allografts retrieved from patients undergoing elective hip replacement were analysed. From 290 femoral head allografts harvested and stored as full (complete) head specimens or as two halves, 101 had to be withdrawn. In total, 104 full and 75 half heads were implanted in 152 recipients. The calculated final product costs were €1367 per full head. Compared with the use of commercially available processed allografts, a saving of at least €43 119 was realised over four-years (€10 780 per year) resulting in a cost-effective intervention at our institution. Assuming a price of between €1672 and €2149 per commercially purchased allograft, breakeven analysis revealed that implanting between 34 and 63 allografts per year equated to the total cost of bone banking.

Effect of angular deformities of the proximal femur on impingement-free hip range of motion in a three-dimensional rigid body model.

Introduction Abnormalities in hip morphology can reduce range of motion (ROM) through femoroacetabular impingement (FAI). Structural issues, such as asphericity of the head-neck junction and regional or global acetabular over-coverage, have been extensively discussed in the literature. The effect of varying femoral neck-shaft angle or torsion on native hip range of motion, however, has been poorly studied. Our hypothesis was that varying neck-shaft angles or femoral torsion affect the impingement-free ROM of the hip and can be treated by femoral osteochondroplasty or acetabular rim resection. Material and methods A computer-aided design tool and a 3-D model of the hip were used to simulate incremental deformation of the proximal femur. Neck-shaft angles ranging from 90-160°, and femoral torsions ranging from -15-50°, were created. Femoroacetabular impingement was defined as bone-to-bone contact within physiological hip ROM, as described in the literature. Results and conclusion With decreasing neck-shaft angles (≤110°) or femoral torsion (≤10°), impingement occurred at the anterosuperior rim area. With increasing neck-shaft angles (≥135°) and femoral torsion (≥25°) posteroinferior or ischiofemoral impingement occurred. Acetabular rim trimming could compensate for neck-shaft angles ≥90° and femoral torsion ≥-5°, without creating acetabular dysplasia. Femoral impingement zones in low neck-shaft and low femoral torsion angles were found to be distal to the head-neck junction at the mid-cervical region. The cross-sectional area at this neck region was the smallest, and thus osteochondroplasty at this location may prove potentially dangerous.

Assessment of Femoral Antetorsion With MRI: Comparison of Oblique Measurements to Standard Transverse Measurements

OBJECTIVE Abnormal femoral antetorsion is associated with the development of femoroacetabular impingement (FAI). Anatomically correct antetorsion measurements are performed on transverse MR images over the proximal and distal femur, but some authors use alternative measurements on oblique images parallel to the femoral neck axis. We set out to assess the relationship between these two measurement methods and to obtain reference values for oblique measurements in patients with FAI and healthy control subjects. We also evaluated whether the oblique measurements could be used to predict the standard transverse measurements. SUBJECTS AND METHODS MRI data of 126 individuals, 63 asymptomatic volunteers and 63 patients with FAI (age 20-50 years), were included in this prospective study. Two readers independently assessed antetorsion with oblique measurements and standard transverse measurements. Differences between subgroups were compared with the unpaired t test. Trigonometric calculations were used to predict standard antetorsion measurements on the basis of oblique measurements. Interobserver agreement and Bland-Altman plots were calculated. RESULTS Reference values for assessing femoral antetorsion with the oblique method were established, with mean (± SD) values of 9.4° ± 7.9° (reader 1) and 9.8° ± 8.4° (reader 2) for patients and 9.2° ± 8.4° (reader 1) and 9.6° ± 9.1° (reader 2) for asymptomatic volunteers. The oblique method generated smaller antetorsion values than the standard transverse method (p < 0.001), with an average difference of 3.5° ± 3.2° for reader 1 and 3.6° ± 3.5° for reader 2. Differences between predicted antetorsion values based on oblique measurements and standard measurements were minimal: 0.1° ± 2.9° (p = 0.62) for reader 1 and 0.3° ± 3.3° (p = 0.29) for reader 2. Interobserver agreement was high for all antetorsion measurements (intra-class correlation coefficient, 0.945-0.977). CONCLUSION Oblique measurements of femoral antetorsion were smaller than standard transverse measurements, but they can be used to accurately predict standard measurements.