Clayton T. Beecham

Myoblastoma of the vulva

Abstract 1. 1. Since granular-cell myoblastoma was first described in 1926, more than 300 cases of this tumor have been reported, 10 of which have occurred on the vulva. We have added 2 additional cases. 2. 2. The tumor occurs as a slowly growing, firm, nontender nodule either fixed to the skin or freely movable in the subcutaneous tissue. It may be present at any age, but is most common in the third, fourth, and fifth decades of life. 3. 3. The histopathology is distinctive, there being irregular strands of large cells containing an abundant amount of granular eosinophilic cytoplasm, and separated by a fibrous network. The nuclei vary somewhat in size and shape, and their morphology is not pathognomonic. 4. 4. The histogenesis of this tumor is disputed. It was originally believed to be derived from striated muscle. The concept of neural origin has recently received the strongest support, but the precise precursor cell—Schwann cell, histiocyte, or fibroblast—remains to be determined. 5. 5. Wide local excision of the tumor is considered curative. Proved instances of malignant change in myoblastoma are few.

Androgen therapy in pelvic malignancy

Abstract 1. Six cases of pelvic malignancy have been submitted to testosterone propionate therapy. 2. Pain was rapidly and almost completely relieved in most cases, and the patients general condition was improved. 3. Androgenic therapy should be further tried in cases of this type.

Evaluation of cervical biopsy in the diagnosis of carcinoma

Abstract 1. History, physical examination, free use of the biopsy, and maintainance of a high index of suspicion have been rewarding in the diagnosis of early cervical carcinoma. 2. Twenty-eight per cent of our cases of carcinoma of the cervix were not clinically evident and were diagnosed by suspicion and biopsy. 3. Resident and teaching staffs caring for private and ward patients have thus far not been responsible for delay in the diagnosis of cervical carcinoma.