Concetta Coronella
Seconda Università degli Studi di Napoli
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Featured researches published by Concetta Coronella.
Fertility and Sterility | 2002
Alberto Falorni; Stefano Laureti; Paola Candeloro; Silvia Perrino; Concetta Coronella; Antonio Bizzarro; Antonio Bellastella; Fausto Santeusanio; Annamaria De Bellis
OBJECTIVE To determine the prevalence of steroid-cell autoantibodies, 3beta-hydroxysteroid dehydrogenase (3beta-HSD) antibodies, 17alpha-hydroxylase (17alpha-OH) antibodies, and P450 side-chain cleavage antibodies in premature ovarian failure. DESIGN Cross-sectional, observational study. SETTING Academic research hospitals. PATIENT(S) Eighty-one women with premature ovarian failure, 20 women with Addison disease not associated with premature ovarian failure, 42 women with type 1 diabetes mellitus, and 90 healthy women. MAIN OUTCOME MEASURE(S) Serum levels of steroid-cell autoantibodies, 17alpha-OH antibodies, P450 side-chain cleavage antibodies, and 3beta-HSD antibodies. RESULT(S) Steroid-cell autoantibodies were present in none of 57 women with isolated premature ovarian failure or premature ovarian failure plus nonadrenal autoimmune disease and in 21 of 24 (87%) women with Addison disease-related premature ovarian failure. 17alpha-Hydroxylase antibodies and P450 side-chain cleavage antibodies were significantly more frequent in women positive for adrenal autoantibodies than in those negative for adrenal autoantibodies (50% vs. 0% and 71% vs. 2%, respectively). The presence of 17alpha-OH antibodies or P450 side-chain cleavage antibodies was strongly associated with presence of steroid-cell autoantibodies. Two of 24 (8%) women with Addison disease-related premature ovarian failure and 1 of 57 (2%) women with isolated premature ovarian failure or premature ovarian failure plus nonadrenal autoimmune disease were positive for 3beta-HSD antibodies. None of 20 adult women with autoimmune Addison disease and none of 42 adult women with type 1 diabetes mellitus not associated with premature ovarian failure was positive for 3beta-HSD antibodies. CONCLUSION(S) Markers of steroid-cell autoimmunity are found only rarely in idiopathic premature ovarian failure not associated with Addison disease. Most women with Addison disease-related premature ovarian failure were positive for steroid-cell autoantibodies, 17alpha-OH antibodies, or P450 side-chain cleavage antibodies. 3beta-Hydroxysteroid dehydrogenase antibodies do not appear to be a major marker of steroid-cell autoimmunity.
Clinical Endocrinology | 2005
A. De Bellis; D. Sansone; Concetta Coronella; Marisa Conte; Sergio Iorio; Silvia Perrino; Marina Battaglia; Giuseppe Bellastella; J. R. Wall; Antonio Bellastella; Antonio Bizzarro
objective In Graves’ ophthalmopathy (GO) intercellular adhesion molecule‐1 (ICAM‐1) is thought to play a key role in lymphocyte infiltration into the orbit, and serum levels of its soluble form are positively correlated to clinical activity score (CAS). Serum antibodies against collagen XIII (CollXIIIAb), a plasma membrane protein expressed at a low level in almost all connective tissue‐producing cells, have been detected in GO, but their significance is unclear. The aim of this study was to search for CollXIIIAb in Graves’ patients with and without ophthalmopathy and to correlate their levels with CAS and with serum soluble ICAM‐1 (sICAM‐1) values.
Clinical Endocrinology | 2005
Annamaria De Bellis; Antonio Bizzarro; Silvia Perrino; Concetta Coronella; Marisa Conte; Daniela Pasquali; Antonio Agostino Sinisi; Corrado Betterle; Antonio Bellastella
Objective In order to investigate whether somatotrophs are the target of antipituitary antibodies (APA) in adult patients with growth hormone deficiency (GHD), we studied the sera of 37 APA positive patients.
Clinical Science | 2008
Annamaria De Bellis; Giuseppe Ruocco; Marina Battaglia; Marisa Conte; Concetta Coronella; Gilda Tirelli; Antonio Bellastella; Elena Pane; Antonio Agostino Sinisi; Antonio Bizzarro; Giuseppe Bellastella
LYH (lymphocytic hypophysitis) is an autoimmune disease of the pituitary gland which can present with varying degrees of pituitary hormonal impairment and/or with symptoms related to pituitary enlargement. In this review, we provide an overview of the epidemiology, diagnosis, pathogenesis, treatment, and the role of organ-specific and antipituitary antibodies as potential markers of LYH. In addition, although the mechanisms underlying LYH are not completely understood, the role of prolactin, which plays an important part in maintaining immune system homoeostasis and is increased in the disease, is considered.
Clinical Endocrinology | 2003
Annamaria De Bellis; Antonio Bizzarro; Marisa Conte; Concetta Coronella; Stefano Solimeno; Silvia Perrino; Daniela Sansone; Mariangela Guaglione; Jack R. Wall; Antonio Bellastella
objective To investigate whether variations over time of TSH‐receptor antibodies (TRAb) and antibodies against G2s (G2sAb) and extraocular muscles (EMAb) can predict worsening of ophthalmopathy in Graves’ patients treated with intravenous glucocorticoid (IVGC) therapy.
Clinical Endocrinology | 2008
A. De Bellis; A. Colao; Alfonso Savoia; Concetta Coronella; Daniela Pasquali; Marisa Conte; Rosario Pivonello; Antonio Bellastella; A. A. Sinisi; Antonio Bizzarro; Gaetano Lombardi; Giuseppe Bellastella
Objective The occurrence of antipituitary antibodies (APA) in patients with idiopathic hyperprolactinaemia (IH) and the effects of dopamine agonists on these antibodies and long‐term pituitary function outcome have been so far not evaluated. This longitudinal study was aimed at investigating, in patients with IH the occurrence of APA and the effect of cabergoline on the pituitary function and behaviour of APA.
Clinical Endocrinology | 2004
A. De Bellis; Silvia Perrino; Concetta Coronella; D. Sansone; Giuseppe Ruocco; Gilda Tirelli; S. Di Martino; Marisa Conte; Giuseppe Bellastella; J. R. Wall; Antonio Bellastella; Antonio Bizzarro
objective The aim of this study was twofold: first to investigate the presence of extraocular muscle antibodies (EMAb) in sera of Graves’ patients with ophthalmopathy characterized by clinical extraocular muscle (EM) involvement; second to evaluate in Graves’ patients without ophthalmopathy whether longitudinal variations of EMAb have a predictive role for the development of eye disease.
L’Endocrinologo | 2006
A. De Bellis; Maria Giovanna Salerno; Marisa Conte; Concetta Coronella; Gilda Tirelli; Marina Battaglia; Valentina Esposito; Giuseppe Ruocco; G. Bellastella; A. Bizzarro; A. Bellastella; Luca Manetti
RiassuntoNei pazienti con deficit idiopatico di GH dell’adulto (GHDI), il rilievo di anticorpi anti-ipofisi (Ab-I) diretti contro le cellule GH-secernenti può indicare la presenza di una patologia ipofisaria autoimmmune. Scopo dello studio è stato quello di 1) valutare la presenza di Ab-I in bambini prepuberi con deficit idiopatico di GH e in bambini con bassa statura idiopatica (BSI), identificando le cellule ipofisarie verso cui erano diretti gli anticorpi anti-ipofisi; 2) verificare se la presenza di Ab-I in bambini con BSI possa essere predittiva dello sviluppo di un deficit di GH (GHD). È stato pertanto eseguito uno studio cross-sectional e in parte longitudinale presso le Unità di Endocrinologia e Pediatria dell’Università di Napoli. Nello studio sono stati arruolati 26 bambini con GHDI (Gruppo 1), 60 bambini con BSI (Gruppo 2), 33 bambini con GHD dovuto a lesioni o anomalie ipotalamo-ipofisarie (Gruppo 3) e infine 40 soggetti di controllo. Diciannove bambini del Gruppo 2 sono stati rivalutati dopo 2 anni. Tutti i pazienti sono stati sottoposti a valutazione della secrezione del GH, alla determinazione dell’IGF-I sierico e degli Ab-I mediante immunofluorescenza indiretta. Al momento dell’arruolamento, Ab-I diretti contro le cellule GH-secernenti sono stati riscontrati in 7 bambini su 26 del Gruppo 1 e in 14 su 60 del Gruppo 2. Diciannove bambini, 8 con Ab-I positiv i e11 con Ab-I negativi, rivalutati 2 anni dopo l’arruolamento nello studio, mostravano lo stesso pattern anticorpale. La rivalutazione della secrezione del GH eseguita 2 anni dopo mostrava lo sviluppo di un GHD in tutti i pazienti con Ab-I positivi tranne uno, mentre nessuno dei pazienti con Ab-I negativi sviluppava GHD. In conclusione, il GHDI nei bambini può essere frequentemente associato con gli Ab-I diretti controllo le cellule GH-secernenti. Il riscontro di Ab-I in bambini con BSI potrebbe identificare coloro che sono predisposti a sviluppare il GHD.
European Journal of Endocrinology | 2003
Antonio Bellastella; Antonio Bizzarro; Concetta Coronella; Giuseppe Bellastella; Antonio Agostino Sinisi; A. De Bellis
The Journal of Clinical Endocrinology and Metabolism | 2003
Annamaria De Bellis; Antonio Bizzarro; Marisa Conte; Silvia Perrino; Concetta Coronella; Stefano Solimeno; Antonia Maria Sinisi; Luisa Anna Stile; Gustavo Pisano; Antonio Bellastella