Cora J. Young

Aquatic persistence of eight pharmaceuticals in a microcosm study

The persistence of eight pharmaceuticals from multiple classes was studied in aquatic outdoor field microcosms. A method was developed for the determination of a mixture of acetaminophen, atorvastatin, caffeine, carbamazepine, levofloxacin, sertraline, sulfamethoxazole, and trimethoprim at microg/L levels from surface water of the microcosms using solid phase extraction and high-performance liquid chromatography-ultraviolet (HPLC-UV) and liquid chromatography tandem mass spectrometry (LC-MS-MS). Half-lives in the field ranged from 1.5 to 82 d. Laboratory persistence tests were performed to determine the relative importance of possible loss processes in the microcosms over the course of the study. Results from dark control experiments suggest hydrolysis was not important in the loss of the compounds. No significant differences were observed between measured half-lives of the pharmaceuticals in sunlight-exposed pond water and autoclaved pond water, which suggests photodegradation was important in limiting their persistence, and biodegradation was not an important loss process in surface water over the duration of the study. Observed photoproducts of several of the pharmaceuticals remained photoreactive, which led to further degradation in irradiated surface waters.

Vertically Resolved Measurements of Nighttime Radical Reservoirs in Los Angeles and Their Contribution to the Urban Radical Budget

Photolabile nighttime radical reservoirs, such as nitrous acid (HONO) and nitryl chloride (ClNO(2)), contribute to the oxidizing potential of the atmosphere, particularly in early morning. We present the first vertically resolved measurements of ClNO(2), together with vertically resolved measurements of HONO. These measurements were acquired during the California Nexus (CalNex) campaign in the Los Angeles basin in spring 2010. Average profiles of ClNO(2) exhibited no significant dependence on height within the boundary layer and residual layer, although individual vertical profiles did show variability. By contrast, nitrous acid was strongly enhanced near the ground surface with much smaller concentrations aloft. These observations are consistent with a ClNO(2) source from aerosol uptake of N(2)O(5) throughout the boundary layer and a HONO source from dry deposition of NO(2) to the ground surface and subsequent chemical conversion. At ground level, daytime radical formation calculated from nighttime-accumulated HONO and ClNO(2) was approximately equal. Incorporating the different vertical distributions by integrating through the boundary and residual layers demonstrated that nighttime-accumulated ClNO(2) produced nine times as many radicals as nighttime-accumulated HONO. A comprehensive radical budget at ground level demonstrated that nighttime radical reservoirs accounted for 8% of total radicals formed and that they were the dominant radical source between sunrise and 09:00 Pacific daylight time (PDT). These data show that vertical gradients of radical precursors should be taken into account in radical budgets, particularly with respect to HONO.

Atmospheric Perfluorinated Acid Precursors: Chemistry, Occurrence, and Impacts

Perfluorocarboxylic acids (PFCAs) can be found from the hydrolysis of perfluoroacyl fluorides and chlorides, which can be produced in three separate ways in the atmosphere. Alternatively, PFCAs can be formed directly in the gas phase through reaction of perfluoroacyl peroxy radicals or perfluorinated aldehyde hydrates. All five mechanisms have been elucidated using smog chamber techniques. Yields of the PFCAs from this process vary from less than 10% to greater than 100%, depending on the mechanism. The formation of perfluorosulfonic acids in the atmosphere can also occur, though the mechanism has not been entirely elucidated. A large number of compounds have been confirmed as perfluorinated acid precursors, including CFC-replacement compounds, anesthetics, fluorotelomer compounds, and perfluorosulfonamides. Levels of some of these compounds have been measured in the atmosphere, but concentration for the majority have yet to be detected. It is clear that atmospheric oxidation of volatile precursors contributes to the overall burden of PFAs, though the extent to which this occurs is compound and environment dependent and is difficult to assess accurately.

Atmospheric Chemistry of 4:2 Fluorotelomer Acrylate [C4F9CH2CH2OC(O)CH=CH2] : Kinetics, Mechanisms, and Products of Chlorine-Atom-and OH-Radical-Initiated Oxidation

Relative rate techniques were used to measure the rate constants k[Cl + C(4)F(9)CH(2)CH(2)OC(O)CH=CH(2)] = (2.21 +/- 0.16) x 10(-10) and k[OH + C(4)F(9)CH(2)CH(2)OC(O)CH=CH(2)] = (1.13 +/- 0.12) x 10(-11) cm(3) molecule(-1) s(-1) in 700 Torr of N(2) or air diluent at 296 K. The atmospheric lifetime of C(4)F(9)CH(2)CH(2)OC(O)CHCH(2) (4:2 FTAc) is determined by its reaction with OH radicals and is approximately 1 day. The chlorine-atom-initiated oxidation of 4:2 FTAc in 700 Torr of air at 296 K gives C(4)F(9)CH(2)C(O)H in molar yields of 18% and 10% in the absence and presence of NO, respectively. The OH-radical-initiated oxidation of 4:2 FTAc in 700 Torr of air in the presence of NO gives HCHO in a molar yield of (102 +/- 7)%, with C(4)F(9)CH(2)CH(2)OC(O)C(O)H (4:2 fluorotelomer glyoxylate) as the expected coproduct. The atmospheric fate of the 4:2 fluorotelomer glyoxylate will be photolysis and reaction with OH radicals, which will lead to the formation of C(4)F(9)CH(2)C(O)H and ultimately perfluorinated carboxylic acids. The atmospheric oxidation of fluorotelomer acrylates is a potential source of perfluorinated carboxylic acids in remote locations.

Atmospheric Chemistry of 4:2 Fluorotelomer Iodide (n-C4F9CH2CH2I): Kinetics and Products of Photolysis and Reaction with OH Radicals and Cl Atoms

Relative rate techniques were used to study the title reactions and determine rate constants of k(Cl + C(4)F(9)CH(2)CH(2)I) = (1.25 +/- 0.15) x 10(-12) and k(OH + C(4)F(9)CH(2)CH(2)I) = (1.2 +/- 0.6) x 10(-12) cm(3) molecule(-1) s(-1) in 700 Torr total pressure at 295 K. The fluorotelomer aldehyde (C(4)F(9)CH(2)CHO), perfluorinated aldehyde (C(4)F(9)CHO), fluorotelomer acid (C(4)F(9)CH(2)C(O)OH), fluorotelomer peracid (C(4)F(9)CH(2)C(O)OOH), and several perfluorocarboxylic acids were detected by in situ FTIR spectroscopy and offline analysis as products of the chlorine atom initiated oxidation of C(4)F(9)CH(2)CH(2)I in air. The UV-visible spectra of C(4)F(9)CH(2)CH(2)I and C(2)H(5)Cl were recorded over the range of 200-400 nm. Photolysis of C(4)F(9)CH(2)CH(2)I gives C(4)F(9)CH(2)CHO as the major observed product. By assumption of a photolysis quantum yield of unity, it was calculated that the atmospheric lifetime of C(4)F(9)CH(2)CH(2)I is determined by photolysis and is a few days. A mechanism for the atmospheric oxidation of fluorotelomer iodides, (C(x)F(2x+1)CH(2)CH(2)I, where x = 2, 4, 6,...) is proposed. Atmospheric oxidation of fluorotelomer iodides is a potential source of perfluorocarboxylic acids.

Measurements of hydroxyl and hydroperoxy radicals during CalNex‐LA: Model comparisons and radical budgets

Measurements of hydroxyl (OH) and hydroperoxy (HO2*) radical concentrations were made at the Pasadena ground site during the CalNex-LA 2010 campaign using the laser-induced fluorescence-fluorescence assay by gas expansion technique. The measured concentrations of OH and HO2* exhibited a distinct weekend effect, with higher radical concentrations observed on the weekends corresponding to lower levels of nitrogen oxides (NOx). The radical measurements were compared to results from a zero-dimensional model using the Regional Atmospheric Chemical Mechanism-2 constrained by NOx and other measured trace gases. The chemical model overpredicted measured OH concentrations during the weekends by a factor of approximately 1.4 ± 0.3 (1σ), but the agreement was better during the weekdays (ratio of 1.0 ± 0.2). Model predicted HO2* concentrations underpredicted by a factor of 1.3 ± 0.2 on the weekends, while measured weekday concentrations were underpredicted by a factor of 3.0 ± 0.5. However, increasing the modeled OH reactivity to match the measured total OH reactivity improved the overall agreement for both OH and HO2* on all days. A radical budget analysis suggests that photolysis of carbonyls and formaldehyde together accounted for approximately 40% of radical initiation with photolysis of nitrous acid accounting for 30% at the measurement height and ozone photolysis contributing less than 20%. An analysis of the ozone production sensitivity reveals that during the week, ozone production was limited by volatile organic compounds throughout the day during the campaign but NOx limited during the afternoon on the weekends.

Size separation method for absorption characterization in brown carbon: Application to an aged biomass burning sample

The majority of brown carbon (BrC) in atmospheric aerosols is derived from biomass burning (BB) and is primarily composed of extremely low volatility organic carbons. We use two chromatographic methods to compare the contribution of large and small light-absorbing BrC components in aged BB aerosols with UV-vis absorbance detection: (1) size exclusion chromatography (SEC) and (2) reverse phase high-performance liquid chromatography. We observe no evidence of small molecule absorbers. Most BrC absorption arises from large molecular weight components (>1000 amu). This suggests that although small molecules may contribute to BrC absorption near the BB source, analyses of aerosol extracts should use methods selective to large molecular weight compounds because these species may be responsible for long-term BrC absorption. Further characterization with electrospray ionization mass spectrometry (MS) coupled to SEC demonstrates an underestimation of the molecular size determined through MS as compared to SEC.

An Atmospheric Constraint on the NO2 Dependence of Daytime Near-Surface Nitrous Acid (HONO)

Recent observations suggest a large and unknown daytime source of nitrous acid (HONO) to the atmosphere. Multiple mechanisms have been proposed, many of which involve chemistry that reduces nitrogen dioxide (NO2) on some time scale. To examine the NO2 dependence of the daytime HONO source, we compare weekday and weekend measurements of NO2 and HONO in two U.S. cities. We find that daytime HONO does not increase proportionally to increases in same-day NO2, i.e., the local NO2 concentration at that time and several hours earlier. We discuss various published HONO formation pathways in the context of this constraint.

Atmospheric Degradation of Perfluoro-2-methyl-3-pentanone: Photolysis, Hydrolysis and Hydration

Perfluorinated carboxylic acids are widely distributed in the environment, including remote regions, but their sources are not well understood. Perfluoropropionic acid (PFPrA, CF(3)CF(2)C(O)OH) has been observed in rainwater but the observed amounts can not be explained by currently known degradation pathways. Smog chamber studies were performed to assess the potential of photolysis of perfluoro-2-methyl-3-pentanone (PFMP, CF(3)CF(2)C(O)CF(CF(3))(2)), a commonly used fire-fighting fluid, to contribute to the observed PFPrA loadings. The photolysis of PFMP gives CF(3)CF(2)C·(O) and ·CF(CF(3))(2) radicals. A small (0.6%) but discernible yield of PFPrA was observed in smog chamber experiments by liquid chromatography-mass spectrometry offline chamber samples. The Tropospheric Ultraviolet-Visible (TUV) model was used to estimate an atmospheric lifetime of PFMP with respect to photolysis of 4-14 days depending on latitude and time of year. PFMP can undergo hydrolysis to produce PFPrA and CF(3)CFHCF(3) (HFC-227ea) in a manner analogous to the Haloform reaction. The rate of hydrolysis was measured using (19)F NMR at two different pHs and was too slow to be of importance in the atmosphere. Hydration of PFMP to give a geminal diol was investigated computationally using density functional theory. It was determined that hydration is not an important environmental fate of PFMP. The atmospheric fate of PFMP seems to be direct photolysis which, under low NO(x) conditions, gives PFPrA in a small yield. PFMP degradation contributes to, but does not appear to be the major source of, PFPrA observed in rainwater.

Biogas Stoves Reduce Firewood Use, Household Air Pollution, and Hospital Visits in Odisha, India

Traditional cooking using biomass is associated with ill health, local environmental degradation, and regional climate change. Clean stoves (liquefied petroleum gas (LPG), biogas, and electric) are heralded as a solution, but few studies have demonstrated their environmental health benefits in field settings. We analyzed the impact of mainly biogas (as well as electric and LPG) stove use on social, environmental, and health outcomes in two districts in Odisha, India, where the Indian government has promoted household biogas. We established a cross-sectional observational cohort of 105 households that use either traditional mud stoves or improved cookstoves (ICS). Our multidisciplinary team conducted surveys, environmental air sampling, fuel weighing, and health measurements. We examined associations between traditional or improved stove use and primary outcomes, stratifying households by proximity to major industrial plants. ICS use was associated with 91% reduced use of firewood (p < 0.01), substantial time savings for primary cooks, a 72% reduction in PM2.5, a 78% reduction in PAH levels, and significant reductions in water-soluble organic carbon and nitrogen (p < 0.01) in household air samples. ICS use was associated with reduced time in the hospital with acute respiratory infection and reduced diastolic blood pressure but not with other health measurements. We find many significant gains from promoting rural biogas stoves in a context in which traditional stove use persists, although pollution levels in ICS households still remained above WHO guidelines.