Craig M. Lancaster

A Comparison of Out-of-Field Dose and Its Constituent Components for Intensity-Modulated Radiation Therapy Versus Conformal Radiation Therapy: Implications for Carcinogenesis

PURPOSE To investigate differences in scatter and leakage between 6-MV intensity-modulated radiation therapy (IMRT) and three-dimensional conformal radiation therapy (3DCRT); to describe the relative contributions of internal patient scatter, collimator scatter, and head leakage; and to discuss implications for second cancer induction. METHODS AND MATERIALS Dose was measured at increasing distances from the field edge in a water bath with a sloping wall (1) under full scatter conditions, (2) with the field edge abutting but outside the bath to prevent internal (water) scatter, and (3) with the beam aperture plugged to reflect leakage only. RESULTS Internal patient scatter from IMRT is 11% lower than 3DCRT, but collimator scatter and head leakage are five and three times higher, respectively. Ultimately, total scattered dose is 80% higher with IMRT; however this difference is small in absolute terms, being 0.14% of prescribed dose. Secondary dose from 3DCRT is mostly due to internal patient scatter, which contributes 70% of the total and predominates until 25 cm from the field edge. For IMRT, however, machine scatter/leakage is the dominant source, contributing 65% of the secondary dose. Internal scatter predominates for just the first 10 cm from field edge, collimator scatter for the next 10 cm, and head leakage thereafter. CONCLUSIONS Out-of-field dose is 80% higher with IMRT, but differences are tiny in absolute terms. Reductions in internal patient scatter with IMRT are outweighed by increased machine scatter and leakage, at least for small fields. Reductions from IMRT in dose to tissues within the portals and in internal scatter, which predominates close to the field edge, means that calculations based solely on dose to distant tissues may overestimate carcinogenic risks.

Effects of changing modulation and pitch parameters on tomotherapy delivery quality assurance plans

This study was aimed at investigating delivery quality assurance (DQA) discrepancies observed for helical tomotherapy plans. A selection of tomotherapy plans that initially failed the DQA process was chosen for this investigation. These plans failed the fluence analysis as assessed using gamma criteria (3%, 3 mm) with radiographic film. Each of these plans was modified (keeping the planning constraints the same), beamlets rebatched and reoptimized. By increasing and decreasing the modulation factor, the fluence in a circumferential plane as measured with a diode array was assessed. A subset of these plans was investigated using varied pitch values. Metrics for each plan that were examined were point doses, fluences, leaf opening times, planned leaf sinograms, and uniformity indices. In order to ensure that the treatment constraints remained the same, the dose‐volume histograms (DVHs) of all the modulated plans were compared to the original plan. It was observed that a large increase in the modulation factor did not significantly improve DVH uniformity, but reduced the gamma analysis pass rate. This also increased the treatment delivery time by slowing down the gantry rotation speed which then increases the maximum to mean non‐zero leaf open time ratio. Increasing and decreasing the pitch value did not substantially change treatment time, but the delivery accuracy was adversely affected. This may be due to many other factors, such as the complexity of the treatment plan and site. Patient sites included in this study were head and neck, right breast, prostate, abdomen, adrenal, and brain. The impact of leaf timing inaccuracies on plans was greater with higher modulation factors. Point‐dose measurements were seen to be less susceptible to changes in pitch and modulation factors. The initial modulation factor used by the optimizer, such that the TPS generated ‘actual’ modulation factor within the range of 1.4 to 2.5, resulted in an improved deliverable plan. PACS number: 87.55.‐x, 87.55.Qr, 87.55.D‐

First experiences in using a dose control system on a TomoTherapy Hi·Art II

The purpose of this study was to investigate the impact of a dose control system (DCS) servo installed on two fully commissioned TomoTherapy Hi·Art II treatment units. This servo is designed to actively adjust machine parameters to control the output variation of a tomotherapy unit to within ±0.5% of the nominal dose rate. Machine output, dose rate, and patient‐specific quality assurance data were retrospectively analyzed for periods prior to and following the installation of the servo system. Quality assurance tests indicate a reduction in the rotational variation of the output during a procedure, where the peak‐to‐peak amplitude of the variation was ±1.30 prior to DCS and equal to ±0.4 with DCS. Comparing two tomotherapy unit static outputs over four years the percentage error was 1.05%±0.7% and −0.4%±0.66% and, once DCS was installed, was reduced to −0.22%±0.29% and −0.08%±0.16% . The results of the quality assurance tests indicate that the dose control system reduced the output variation of each machine for both static and rotational delivery, leading to an improvement in the overall performance of the machine and providing greater certainty in treatment delivery. PACS number: 87.56.‐v, 87.56.bd, 87.55.Qr, 87.56.Fc

Constituent Components of Out-of-Field Scatter Dose for 18-MV Intensity Modulated Radiation Therapy Versus 3-Dimensional Conformal Radiation Therapy: A Comparison With 6-MV and Implications for Carcinogenesis

PURPOSE To characterize and compare the components of out-of-field dose for 18-MV intensity modulated radiation therapy (IMRT) versus 3-dimensional conformal radiation therapy (3D-CRT) and their 6-MV counterparts and consider implications for second cancer induction. METHODS AND MATERIALS Comparable plans for each technique/energy were delivered to a water phantom with a sloping wall; under full scatter conditions; with field edge abutting but outside the bath to prevent internal/phantom scatter; and with shielding below the linear accelerator head to attenuate head leakage. Neutron measurements were obtained from published studies. RESULTS Eighteen-megavolt IMRT produces 1.7 times more out-of-field scatter than 18-MV 3D-CRT. In absolute terms, however, differences are just approximately 0.1% of central axis dose. Eighteen-megavolt IMRT reduces internal/patient scatter by 13%, but collimator scatter (C) is 2.6 times greater than 18-MV 3D-CRT. Head leakage (L) is minimal. Increased out-of-field photon scatter from 18-MV IMRT carries out-of-field second cancer risks of approximately 0.2% over and above the 0.4% from 18-MV 3D-CRT. Greater photoneutron dose from 18-MV IMRT may result in further maximal, absolute increased risk to peripheral tissue of approximately 1.2% over 18-MV 3D-CRT. Out-of-field photon scatter remains comparable for the same modality irrespective of beam energy. Machine scatter (C+L) from 18 versus 6 MV is 1.2 times higher for IMRT and 1.8 times for 3D-CRT. It is 4 times higher for 6-MV IMRT versus 3D-CRT. Reduction in internal scatter with 18 MV versus 6 MV is 27% for 3D-CRT and 29% for IMRT. Compared with 6-MV 3D-CRT, 18-MV IMRT increases out-of-field second cancer risk by 0.2% from photons and adds 0.28-2.2% from neutrons. CONCLUSIONS Out-of-field photon dose seems to be independent of beam energy for both techniques. Eighteen-megavolt IMRT increases out-of-field scatter 1.7-fold over 3D-CRT because of greater collimator scatter despite reducing internal/patient scatter. Out-of-field carcinogenic risk is thus increased (but improved in-field dose conformity may offset this). Potentially increased carcinogenic risk should be weighed against any benefit 18-MV IMRT may provide.

Statistical process control and verifying positional accuracy of a cobra motion couch using step‐wedge quality assurance tool

Abstract This study utilizes process control techniques to identify action limits for TomoTherapy couch positioning quality assurance tests. A test was introduced to monitor accuracy of the applied couch offset detection in the TomoTherapy Hi‐Art treatment system using the TQA “Step‐Wedge Helical” module and MVCT detector. Individual X‐charts, process capability (cp), probability (P), and acceptability (cpk) indices were used to monitor a 4‐year couch IEC offset data to detect systematic and random errors in the couch positional accuracy for different action levels. Process capability tests were also performed on the retrospective data to define tolerances based on user‐specified levels. A second study was carried out whereby physical couch offsets were applied using the TQA module and the MVCT detector was used to detect the observed variations. Random and systematic variations were observed for the SPC‐based upper and lower control limits, and investigations were carried out to maintain the ongoing stability of the process for a 4‐year and a three‐monthly period. Local trend analysis showed mean variations up to ±0.5 mm in the three‐monthly analysis period for all IEC offset measurements. Variations were also observed in the detected versus applied offsets using the MVCT detector in the second study largely in the vertical direction, and actions were taken to remediate this error. Based on the results, it was recommended that imaging shifts in each coordinate direction be only applied after assessing the machine for applied versus detected test results using the step helical module. User‐specified tolerance levels of at least ±2 mm were recommended for a test frequency of once every 3 months to improve couch positional accuracy. SPC enables detection of systematic variations prior to reaching machine tolerance levels. Couch encoding system recalibrations reduced variations to user‐specified levels and a monitoring period of 3 months using SPC facilitated in detecting systematic and random variations. SPC analysis for couch positional accuracy enabled greater control in the identification of errors, thereby increasing confidence levels in daily treatment setups.

A unique approach to high-dose-rate vaginal mold brachytherapy of gynecologic malignancies

PURPOSE Patients with cervical and vaginal cancer sometimes have a less straightforward approach for choice of brachytherapy treatment owing to the tumors location and clinical presentation. The staff at Royal Brisbane & Womens Hospital in Queensland, Australia, is trying to solve this problem by the use of an old technique in a new approach called vaginal molds. With a patient-specific vaginal mold, the appearance of the applicator and the dose distribution can be customized to provide an optimal treatment for each patient. METHODS AND MATERIALS The technique used at the Royal Brisbane & Womens Hospital uses a flexible two-part putty, moulded to the shape of the vagina, in which standard catheters (flexible implant tubes) are incorporated, in a pattern designed to permit a dose distribution more conformal to the target volume. RESULTS The presented technique is efficient and improves the accuracy of a homogeneous target cover and sparing of organs at risk for vaginal mold brachytherapy treatments at our institution. CONCLUSION This technique offers a customizable option when traditional cylindrical- or dome-type applicators cannot be used, or provide inadequate dose coverage. Molds to match the patient anatomy can be created quickly, while allowing flexibility in positioning of catheters to achieve the desired dose distribution.

Investigating output and energy variations and their relationship to delivery QA results using Statistical Process Control for helical tomotherapy

The aims of this study were to investigate machine beam parameters using the TomoTherapy quality assurance (TQA) tool, establish a correlation to patient delivery quality assurance results and to evaluate the relationship between energy variations detected using different TQA modules. TQA daily measurement results from two treatment machines for periods of up to 4years were acquired. Analyses of beam quality, helical and static output variations were made. Variations from planned dose were also analysed using Statistical Process Control (SPC) technique and their relationship to output trends were studied. Energy variations appeared to be one of the contributing factors to delivery output dose seen in the analysis. Ion chamber measurements were reliable indicators of energy and output variations and were linear with patient dose verifications.

Radiotherapy Quality Assurance Using Statistical Process Control

Statistical process control (SPC) is an analytical decision-making tool that employs statistics to measure and monitor a system process. The fundamental concept of SPC is to compare current statistics in a process with its previous corresponding statistic for a given period. Using SPC, a control chart is obtained to identify random and systematic variations based on the mean of the process and trends are observed to see how data can vary in each evaluated period. An upper and lower control limit in an SPC derived control chart indicate the range of the process calculated based on the standard deviations from the mean, thereby points that are outside these limits indicate the process to be out of control. Metrics such as: process capability and acceptability ratios were employed to assess whether an applied tolerance is applicable to the existing process. SPC has been applied in this study to assess and recommend quality assurance tolerances in the radiotherapy practice for helical tomotherapy. Various machine parameters such as beam output, energy, couch travel as well as treatment planning parameters such as minimum percentage of open multileaf collimators (MLC) during treatment, planned pitch (couch travel per gantry rotation) and modulation factor (beam intensity) were verified against their delivery quality assurance tolerances to produce SPC based tolerances. Results obtained were an indication of the current processes and mechanical capabilities in the department rather than a vendor recommended or a prescriptive approach based on machine technicalities. In this study, we have provided a simple yet effective method and analysis results to recommend tolerances for a radiotherapy practice. This can help improve treatment efficiency and reduce inaccuracies in dose delivery using an assessment tool that can identify systematic and random variations in a process and hence avoid potential hazardous outcomes.

Tomotherapy treatment site specific planning using statistical process control

BACKGROUND This study investigated planned MLC distribution and treatment region specific plan parameters to recommend optimal delivery parameters based on statistical process techniques. METHODS A cohort of 28 head and neck, 19 pelvic and 23 brain pre-treatment plans were delivered on a helical tomotherapy system using 2.5 cm field width. Parameters such as gantry period, leaf open time (LOT), actual modulation factor, LOT sonogram, treatment duration and couch travel were investigated to derive optimal range for plans that passed acceptable delivery quality assurance. The results were compared against vendor recommendations and previous publications. RESULTS No correlation was observed between vendor recommended gantry period and percentage of minimum leaf open times. The range of gantry period (min-max) observed was 16-21 s for head and neck, 15-22 s for pelvis and 13-18 s for brain plans respectively. It was also noted that the highest percentage (average (X-) ± SD) of leaf open times for a minimum time of 100 ms was seen for brain plans (53.9 ± 9.2%) compared to its corresponding head and neck (34.5 ± 4.2%) and pelvic (32.0 ± 9.4%) plans respectively. CONCLUSIONS We have proposed that treatment site specific delivery parameters be used during planning that are based on the treatment centre and have detailed recommendations and limitations for the studied cohort. This may enable to improve efficiency of treatment deliveries by reducing inaccuracies in MLC distribution.

Monte Carlo Simulation of Respiratory Motion Induced Penumbral Broadening in Dose Distribution Using PENELOPE

Background: Image guided respiratory gating for lung and liver cancers was commissioned at William Buckland Radiotherapy Centre. Treatments are delivered on a Novalis Classic accelerator with Brainlab ExacTracTM robotic couch capable of tracking implanted fiducial markers.