Craig Watson

The EADC-ADNI Harmonized Protocol for manual hippocampal segmentation on magnetic resonance: Evidence of validity

An international Delphi panel has defined a harmonized protocol (HarP) for the manual segmentation of the hippocampus on MR. The aim of this study is to study the concurrent validity of the HarP toward local protocols, and its major sources of variance.

Operationalizing protocol differences for EADC-ADNI manual hippocampal segmentation

Hippocampal volumetry on magnetic resonance imaging is recognized as an Alzheimers disease (AD) biomarker, and manual segmentation is the gold standard for measurement. However, a standard procedure is lacking. We operationalize and quantitate landmark differences to help a Delphi panel converge on a set of landmarks.

Relationship between hippocampal atrophy and neuropathology markers: a 7T MRI validation study of the EADC-ADNI Harmonized Hippocampal Segmentation Protocol

The pathologic validation of European Alzheimers Disease Consortium Alzheimer’s Disease Neuroimaging Initiative Center Harmonized Hippocampal Segmentation Protocol (HarP).

Evaluation of oculocephalic sympathetic function in vascular headache syndromes. Part II. Oculocephalic sympathetic function in cluster headache.

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Exposure to Sun and Precipitation of Migraine

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Site of Injury Headache

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Volumetric magnetic resonance imaging in patients with epilepsy and extratemporal structural lesions

Abstract We studied 30 patients with epilepsy and extratemporal structural lesions using volumetric magnetic resonance imaging (MRI) measurements of the amygdala and hippocampus to determine if seizures originating in extratemporal sites caused cell loss and atrophy of medial temporal structures. Seizure types included simple partial seizures in 22 patients, complex partial in 12, secondarily generalized in 15, and drop attacks in 2. The location of the MRI lesions was in the frontal lobe in 19 patients, parietal lobe in 11, occipital lobe in 4, intraventricular in 1, and multifocal in 1. Lesions included tumors in 8 patients, developmental anomalies in 8, atrophic lesions in 6, vascular malformations in 4, and cystic, traumatic, gliotic, and ischemic lesions in 1 each. Hippocampal and amygdaloid volumes were within the normal range in all patients when compared to the normal control group. One patient exhibited a mild asymmetry of the two sides, but this was felt to be part of the larger process of her structural lesion. Significant reduction in hippocampal and amygdaloid volumes is a specific marker for hippocampal and amygdaloid sclerosis.

Corneal sensitivity in cluster headache

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