Cristina Mapp
University of Ferrara
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Publication
Featured researches published by Cristina Mapp.
Journal of Clinical Investigation | 2001
Paola Panina-Bordignon; Alberto Papi; Margherita Mariani; Pietro Di Lucia; Gianluca Casoni; Cinzia Maria Bellettato; Cecilia Buonsanti; Deborah Miotto; Cristina Mapp; Antonello Villa; Gianluigi Arrigoni; Leonardo M. Fabbri; Francesco Sinigaglia
In vitro polarized human Th2 cells preferentially express the chemokine receptors CCR3, CCR4, and CCR8 and migrate to their ligands: eotaxin, monocyte-derived chemokine (MDC), thymus- and activation-regulated chemokine (TARC), and I-309. We have studied the expression of chemokines and chemokine receptors in the airway mucosa of atopic asthmatics. Immunofluorescent analysis of endobronchial biopsies from six asthmatics, taken 24 hours after allergen challenge, demonstrates that virtually all T cells express IL-4 and CCR4. CCR8 is coexpressed with CCR4 on 28% of the T cells, while CCR3 is expressed on eosinophils but not on T cells. Expression of the CCR4-specific ligands MDC and TARC is strongly upregulated on airway epithelial cells upon allergen challenge, suggesting an involvement of this receptor/ligand axis in the regulation of lymphocyte recruitment into the asthmatic bronchi. In contrast to asthma, T cells infiltrating the airways of patients with chronic obstructive pulmonary disease and pulmonary sarcoidosis produce IFN-gamma and express high levels of CXCR3, while lacking CCR4 and CCR8 expression. These data support the role of CCR4, of its ligands MDC and TARC, and of CCR8 in the pathogenesis of allergen-induced late asthmatic responses and suggest that these molecules could be considered as targets for therapeutic intervention.
The Journal of Allergy and Clinical Immunology | 2009
Piero Maestrelli; Piera Boschetto; Leonardo M. Fabbri; Cristina Mapp
Inhalation of agents in the workplace can induce asthma in a relatively small proportion of exposed workers. Like nonoccupational asthma, occupational asthma is probably the result of multiple genetic, environmental, and behavioral influences. It is important that occupational asthma be recognized clinically because it has serious medical and socioeconomic consequences. Environmental factors that can affect the initiation of occupational asthma include the intrinsic characteristics of causative agents as well as the influence of the level and route of exposure at the workplace. The identification of host factors, polymorphisms, and candidate genes associated with occupational asthma may improve our understanding of mechanisms involved in asthma. High-molecular-weight compounds from biological sources and low-molecular-weight chemicals cause occupational asthma after a latent period of exposure. Although the clinical, functional, and pathologic features of occupational asthma caused by low-molecular-weight agents resemble those of allergic asthma, the failure to detect specific IgE antibodies against most low-molecular-weight agents has resulted in a search for alternative or complementary physiopathologic mechanisms leading to airway sensitization. Recent advances have been made in the characterization of the immune response to low-molecular-weight agents. In contrast, the mechanism of the type of occupational asthma that occurs without latency after high-level exposure to irritants remains undetermined.
Journal of Occupational Medicine and Toxicology | 2006
Piera Boschetto; Sonia Quintavalle; Deborah Miotto; Natalina Lo Cascio; Elena Zeni; Cristina Mapp
Chronic obstructive pulmonary disease (COPD) is one of the leading causes of morbidity and mortality in both industrialized and developing countries.Cigarette smoking is the major risk factor for COPD. However, relevant information from the literature published within the last years, either on general population samples or on workplaces, indicate that about 15% of all cases of COPD is work-related.Specific settings and agents are quoted which have been indicated or confirmed as linked to COPD. Coal miners, hard-rock miners, tunnel workers, concrete-manufacturing workers, nonmining industrial workers have been shown to be at highest risk for developing COPD.Further evidence that occupational agents are capable of inducing COPD comes from experimental studies, particularly in animal models.In conclusion, occupational exposure to dusts, chemicals, gases should be considered an established, or supported by good evidence, risk factor for developing COPD. The implications of this substantial occupational contribution to COPD must be considered in research planning, in public policy decision-making, and in clinical practice.
Clinical & Experimental Allergy | 2009
Cristina Mapp; S. Ferrazzoni; Roberta Rizzo; Deborah Miotto; Marina Stignani; Piera Boschetto; Piero Maestrelli; Olavio R. Baricordi
Background We previously reported that in moderate‐to‐severe asthma there is a deficit of IL‐10 secretion that could prevent the production of soluble HLA‐G (sHLA‐G), a non‐classical human leucocyte antigen class I molecule with tissue‐protective properties in inflammatory responses.
The New England Journal of Medicine | 2000
Cristina Mapp
Chronic obstructive pulmonary disease (COPD) is a group of disorders characterized by a poorly reversible limitation of airflow that is usually progressive and associated with a persistent inflamma...
The Journal of Allergy and Clinical Immunology | 2005
Roberta Rizzo; Cristina Mapp; Loredana Melchiorri; Piero Maestrelli; Annalisa Visentin; Stefano Ferretti; Ilaria Bononi; Deborah Miotto; Olavio R. Baricordi
Lung Cancer | 2008
Piera Boschetto; Elena Zeni; Lucia Mazzetti; Deborah Miotto; Natalina Lo Cascio; Piero Maestrelli; Emanuela Marian; Patrizia Querzoli; Massimo Pedriali; Bruno Murer; Edoardo De Rosa; Leonardo M. Fabbri; Cristina Mapp
Pulmonary Pharmacology & Therapeutics | 2005
Piera Boschetto; Deborah Miotto; Ilaria Bononi; Diego Faggian; Mario Plebani; Alberto Papi; Christophe Créminon; Edoardo De Rosa; Leonardo M. Fabbri; Cristina Mapp
American Thoracic Society Annual Meeting | 2006
Maurizio Luisetti; Begona Casado; I Cerveri; Piera Boschetto; Cristina Mapp; Angelo Corsico; E Pozzi; Elena Ansaldo; Lm Fabbri; Paolo Iadarola; James N. Baraniuk
PROCEEDINGS OF THE AMERICAN THORACIC SOCIETY | 2005
Piera Boschetto; Sonia Quintavalle; Elena Zeni; S Leprotti; Alfredo Potena; L Ballerin; G Palladini; Maurizio Luisetti; Edoardo De Rosa; Lm Fabbri; Cristina Mapp