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Featured researches published by Cristina Tuchilus.


Medicinal Chemistry Research | 2014

Design, synthesis, and antimicrobial activity of some novel homodrimane sesquiterpenoids with diazine skeleton

Kaleria Kuchkova; Aculina Aricu; Elena Secara; Alic Barba; P. F. Vlad; N. D. Ungur; Cristina Tuchilus; Sergiu Shova; Gheorghita Zbancioc; Ionel I. Mangalagiu

Herein we report a feasible study concerning the design, synthesis, and in vitro antimicrobial activity of some novel homodrimane sesquiterpenoids with diazine skeleton. The reaction pathway is efficient and straight, involving the direct N-acylation of diazine with homodrimane sesquiterpenoids bearing acyl chlorides or organic acids functionality. A reliable explication and a feasible reaction mechanism for the obtained compounds are presented. The in vitro antimicrobial activity of the homodrimane sesquiterpenoids with and without diazine skeleton has been evaluated. All the tested compounds have an excellent antibacterial activity against Gram-positive strains S. aureus and B. cereus. SAR correlations concerning antimicrobial activity are reported.Graphical AbstractThe design, synthesis, and in vitro antimicrobial activity of some novel homodrimane sesquiterpenoids with diazine skeleton are described. Antimicrobial tests prove that some homodrimane sesquiterpenoids have an excellent biological activity.


Medicinal Chemistry | 2014

Synthesis and in vitro analysis of novel dihydroxyacetophenone derivatives with antimicrobial and antitumor activities.

Ana Maria Zbancioc; Anca Miron; Cristina Tuchilus; Pincu Rotinberg; Cosmin Mihai; Ionel I. Mangalagiu; Gheorghita Zbancioc

Herein we report a feasible study concerning the design, syntheses and in vitro antimicrobial and antitumoral activities of some novel compounds with dihydroxyacetophenone (DA) moiety. An efficient and general method for the preparation of diazine with dihydroxyacetophenone (DDA) skeleton under conventional thermal heating (TH), microwave (MW) and ultrasounds (US) irradiation is presented. Antimicrobial and antitumoral tests prove that some dihydroxyacetophenone compounds (the brominated derivatives BrDA 3) have a significant biological activity. It is also to be pointed out that, basically all the dihydroxyacetophenone derivatives proved to have a powerful antibacterial activity against drug resistant Gram-negative strain Pseudomonas aeruginosa ATCC 27853. Of particular interest could be the excellent antibacterial activity of our dihydroxyacetophenone compounds against drug resistant Gram-negative strain Pseudomonas aeruginosa.


Journal of Heterocyclic Chemistry | 2007

Pyridazine and phthalazine derivatives with potential antimicrobial activity

Roxana M. Butnariu; Maria Caprosu; Vasilichia Bejan; Ionel I. Mangalagiu; Margareta Ungureanu; Antonia Poiata; Cristina Tuchilus; Margareta Florescu


European Journal of Medicinal Chemistry | 2013

New pyridazine-fluorine derivatives: synthesis, chemistry and biological activity. Part II.

Roxana-Angela Tucaliuc; Valeriu V. Cotea; Marius Niculaua; Cristina Tuchilus; Dorina Mantu; Ionel I. Mangalagiu


Turkish Journal of Biology | 2013

Evaluation of phytotoxic and mutagenic effects of some cinnamic acid derivatives using the Triticum test

Alexandra Jitareanu; Silvica Padureanu; Gabriela Tataringa; Cristina Tuchilus; Ursula Stanescu


Revista medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti din Iaş̧i | 2011

Antimicrobial activity of some cinnamic acid derivatives

Alexandra Jităreanu; Gabriela Tătărîngă; Ana-Maria Zbancioc; Cristina Tuchilus; Ursula Stănescu


Toxicology Letters | 2008

Aflatoxigenic fungi isolated from medicinal herbs

Cornelia Mircea; Antonia Poiata; Cristina Tuchilus; Luminita Agoroaei; Elena Butnaru; Ursula Stanescu


Journal of The Serbian Chemical Society | 2013

Composition, antioxidant and antimicrobial activity of the essential oils of a full grown tree of Pinus cembra L. from the Calimani mountains (Romania)

Lungu Cristina Apetrei; Adrian Spac; Mihai Brebu; Cristina Tuchilus; Anca Miron


Comptes Rendus Chimie | 2016

Benzoate liquid crystals with direct isotropic–smectic transition and antipathogenic activity

Daniela Ailincai; Luminita Marin; Sergiu Shova; Cristina Tuchilus


Revista medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti din Iaş̧i | 2015

α,β-DIBROMOCHALCONE DERIVATIVES--SYNTHESIS AND ANTIMICROBIAL ACTIVITY.

Alexandra Jităreanu; Ana-Maria Zbancioc; Cristina Tuchilus; Mihaela Balan; Ursula Stănescu; Gabriela Tătărîngă

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Ionel I. Mangalagiu

Alexandru Ioan Cuza University

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Cornelia Mircea

Grigore T. Popa University of Medicine and Pharmacy

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Gheorghita Zbancioc

Alexandru Ioan Cuza University

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Alexandra Jitareanu

Grigore T. Popa University of Medicine and Pharmacy

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Gabriela Tataringa

Grigore T. Popa University of Medicine and Pharmacy

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Ana Maria Balan

Alexandru Ioan Cuza University

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Ana Maria Zbancioc

Alexandru Ioan Cuza University

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Andreia Corciova

Grigore T. Popa University of Medicine and Pharmacy

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