Cristina Tuchilus
Grigore T. Popa University of Medicine and Pharmacy
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Publication
Featured researches published by Cristina Tuchilus.
Medicinal Chemistry Research | 2014
Kaleria Kuchkova; Aculina Aricu; Elena Secara; Alic Barba; P. F. Vlad; N. D. Ungur; Cristina Tuchilus; Sergiu Shova; Gheorghita Zbancioc; Ionel I. Mangalagiu
Herein we report a feasible study concerning the design, synthesis, and in vitro antimicrobial activity of some novel homodrimane sesquiterpenoids with diazine skeleton. The reaction pathway is efficient and straight, involving the direct N-acylation of diazine with homodrimane sesquiterpenoids bearing acyl chlorides or organic acids functionality. A reliable explication and a feasible reaction mechanism for the obtained compounds are presented. The in vitro antimicrobial activity of the homodrimane sesquiterpenoids with and without diazine skeleton has been evaluated. All the tested compounds have an excellent antibacterial activity against Gram-positive strains S. aureus and B. cereus. SAR correlations concerning antimicrobial activity are reported.Graphical AbstractThe design, synthesis, and in vitro antimicrobial activity of some novel homodrimane sesquiterpenoids with diazine skeleton are described. Antimicrobial tests prove that some homodrimane sesquiterpenoids have an excellent biological activity.
Medicinal Chemistry | 2014
Ana Maria Zbancioc; Anca Miron; Cristina Tuchilus; Pincu Rotinberg; Cosmin Mihai; Ionel I. Mangalagiu; Gheorghita Zbancioc
Herein we report a feasible study concerning the design, syntheses and in vitro antimicrobial and antitumoral activities of some novel compounds with dihydroxyacetophenone (DA) moiety. An efficient and general method for the preparation of diazine with dihydroxyacetophenone (DDA) skeleton under conventional thermal heating (TH), microwave (MW) and ultrasounds (US) irradiation is presented. Antimicrobial and antitumoral tests prove that some dihydroxyacetophenone compounds (the brominated derivatives BrDA 3) have a significant biological activity. It is also to be pointed out that, basically all the dihydroxyacetophenone derivatives proved to have a powerful antibacterial activity against drug resistant Gram-negative strain Pseudomonas aeruginosa ATCC 27853. Of particular interest could be the excellent antibacterial activity of our dihydroxyacetophenone compounds against drug resistant Gram-negative strain Pseudomonas aeruginosa.
Journal of Heterocyclic Chemistry | 2007
Roxana M. Butnariu; Maria Caprosu; Vasilichia Bejan; Ionel I. Mangalagiu; Margareta Ungureanu; Antonia Poiata; Cristina Tuchilus; Margareta Florescu
European Journal of Medicinal Chemistry | 2013
Roxana-Angela Tucaliuc; Valeriu V. Cotea; Marius Niculaua; Cristina Tuchilus; Dorina Mantu; Ionel I. Mangalagiu
Turkish Journal of Biology | 2013
Alexandra Jitareanu; Silvica Padureanu; Gabriela Tataringa; Cristina Tuchilus; Ursula Stanescu
Revista medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti din Iaş̧i | 2011
Alexandra Jităreanu; Gabriela Tătărîngă; Ana-Maria Zbancioc; Cristina Tuchilus; Ursula Stănescu
Toxicology Letters | 2008
Cornelia Mircea; Antonia Poiata; Cristina Tuchilus; Luminita Agoroaei; Elena Butnaru; Ursula Stanescu
Journal of The Serbian Chemical Society | 2013
Lungu Cristina Apetrei; Adrian Spac; Mihai Brebu; Cristina Tuchilus; Anca Miron
Comptes Rendus Chimie | 2016
Daniela Ailincai; Luminita Marin; Sergiu Shova; Cristina Tuchilus
Revista medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti din Iaş̧i | 2015
Alexandra Jităreanu; Ana-Maria Zbancioc; Cristina Tuchilus; Mihaela Balan; Ursula Stănescu; Gabriela Tătărîngă