Crystal G. Bashore | Researchain

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Featured researches published by Crystal G. Bashore.

Journal of the American Chemical Society | 2008

Structural and Rate Studies of the Formation of Substituted Benzynes

Jason C. Riggs; Antonio J. Ramirez; Matthew E. Cremeens; Crystal G. Bashore; John Candler; Michael C. Wirtz; Jotham Wadsworth Coe; David B. Collum

The key elimination step for the formation of 3-substituted and 3,6-disubstituted benzynes from 2-haloaryllithiums displays a pronounced solvent-dependent regioselectivity. All 2-haloaryllithiums with electron withdrawing groups in the 6 position are shown by 6Li and 13C NMR spectroscopic studies to be monomers in THF. DFT computational studies implicate trisolvates. Rate studies reveal that LiF eliminates via monomer-based pathways requiring THF dissociation whereas LiCl eliminates via nondissociative pathways. Elimination to form 3-chloro- and 3-fluorobenzyne from 2-chloro-6-fluorophenyllithium displays a pronounced solvent-dependent regioselectivity that is traced to competing solvent-dissociative and nondissociative dissociative pathways for the elimination of LiCl and LiF, respectively.

Bioorganic & Medicinal Chemistry Letters | 2005

3,5-Bicyclic aryl piperidines: A novel class of α4β2 neuronal nicotinic receptor partial agonists for smoking cessation

Jotham Wadsworth Coe; Paige R. Brooks; Michael C. Wirtz; Crystal G. Bashore; Krista E. Bianco; Michael G. Vetelino; Eric P. Arnold; Lorraine A. Lebel; Carol B. Fox; F. David Tingley; David W. Schulz; Thomas I. Davis; Steven Bradley Sands; Robert S. Mansbach; Hans Rollema; Brian T. O’Neill

Bioorganic & Medicinal Chemistry Letters | 2005

In pursuit of α4β2 nicotinic receptor partial agonists for smoking cessation: Carbon analogs of (−)-cytisine

Jotham Wadsworth Coe; Michael G. Vetelino; Crystal G. Bashore; Michael C. Wirtz; Paige R. Brooks; Eric P. Arnold; Lorraine A. Lebel; Carol B. Fox; Steven Bradley Sands; Thomas I. Davis; David W. Schulz; Hans Rollema; F. David Tingley; Brian T. O’Neill

Journal of the American Chemical Society | 2003

Twisted Amide Reduction under Wolff−Kishner Conditions: Synthesis of a Benzo-1-Aza-Adamantane Derivative

Crystal G. Bashore; Ivan Samardjiev; Jon Bordner; Jotham Wadsworth Coe

Tetrahedron Letters | 2008

Pyridine analogs of (-)-cytisine and varenicline : cholinergic receptor probes

Sebastien Demers; Heather Stevenson; John Candler; Crystal G. Bashore; Eric P. Arnold; Brian T. O’Neill; Jotham Wadsworth Coe

Organic Letters | 2006

Enantioselective Synthesis of Nicotinic Receptor Probe 7,8-Difluoro-1,2,3,4,5,6- hexahydro-1,5-methano-3-benzazocine

Crystal G. Bashore; Michael G. Vetelino; Michael C. Wirtz; Paige R. Brooks; Heather N. Frost; Ruth E. McDermott; David C. Whritenour; John A. Ragan; Jennifer L. Rutherford; Teresa W. Makowski; and Steven J. Brenek; Jotham Wadsworth Coe

Journal of the American Chemical Society | 2004