Curtis A. Smith

Effect of Antrum Transplantation on Gastric Secretion in Experimental Animals.

Conclusions 1. Exteriorization of the antrum of the stomach produces a marked decrease in the secretion of Pavlov pouch dogs comparable to that secured by excision of the antrum. When this exteriorized antrum is subsequently transplanted into the duodenum or into the colon, a marked stimulation of gastric secretion is produced. 2. Transplantation of the antrum of dogs with totally isolated stomach pouches into the duodenum or into the colon produces a marked increase in gastric secretion. These findings support the view that the antrum mucosa is a specific internal secreting organ distinct in function from the mucous membrane of the stomach or duodenum.

On the insulin content of pancreatic juice.

Summary Commarized insulin added to fresh pancreatic juice can be extracted from the juice and its effect noted on the glucose uptake by the diaphragm in quantities as small as 0.0045 unit per milliliter juice. In extracting pancreatic juice alone, no clear-cut demonstration of insulin effect (i.e., an increase in glucose uptake of 50-100%) could be obtained, even though the extracts of as much as 7 milliliters of fresh juice per milliliter of substrate were tested. (The 20 to 25% averaged increase of glucose uptake by pancreatic juice is not of statistical significance.) Thus if insulin is present in pancreatic juice, the amount extractable and detectable by our methouds must be less than .005/7 or .0007 unit per milliliter of juice.