Edward H. Storer

Effect of Antrum Transplantation on Gastric Secretion in Experimental Animals.

Conclusions 1. Exteriorization of the antrum of the stomach produces a marked decrease in the secretion of Pavlov pouch dogs comparable to that secured by excision of the antrum. When this exteriorized antrum is subsequently transplanted into the duodenum or into the colon, a marked stimulation of gastric secretion is produced. 2. Transplantation of the antrum of dogs with totally isolated stomach pouches into the duodenum or into the colon produces a marked increase in gastric secretion. These findings support the view that the antrum mucosa is a specific internal secreting organ distinct in function from the mucous membrane of the stomach or duodenum.

Supra-Diaphragmatic Section of the Vagus Nerves and Gastric Motility in Patients with Peptic Ulcer

Conclusion 1. When examined by the balloon technic, the empty stomach of patients with peptic ulcer usually displays hypermotility. 2. Bilateral section of the vagus nerves in patients with peptic ulcer decreases the gastric tonus and hunger concentrations of the empty stomach.

Supra-Diaphragmatic Section of Vagus Nerves and Gastric Secretion in Patients with Peptic Ulcer

The studies on gastric secretion to be reported in this paper were performed on 19 patients with duodenal ulcers both before and after division of all vagus fibers to the stomach. The nerves were divided just above the diaphragm by a method previously described. 1 Observations have been made on the continuous night secretion of gastric juice, and the secretory response to histamine, caffeine, insulin, and sham feeding. a. Continuous Night Secretion. There are surprisingly few data on the secretion of the empty stomach of ulcer patients in the absence of any known gastric stimulant. The studies embodied in this report were made as follows: At 9:00 p.m. the stomach was emptied and lavaged with an Ewald tube. When the returns were clear, a Levine tube was introduced through the nose into the stomach and continuous suction maintained until 9:00 a.m. with the Wangensteen apparatus. In 9 patients with carcinoma of the stomach an average of 261 cc of secretion was obtained with a free acidity between 0 and 21 clinical units. In 5 patients with carcinoma of the colon an average of 238 cc was obtained with a free acidity between 0 and 18 clinical units. In 6 patients with gall stones an average of 385 cc of secretion was obtained with a free acidity of 0 to 13 clinical units. In contrast to these findings in 19 patients with duodenal ulcer the night secretion averaged 820 cc with a free acidity between 24 and 82 clinical units. After recovery from the operation for division of the vagus nerves, the ulcer patients secreted an average of 415 cc with a free acidity between O and 61 clinical units. These observations indicate an abnormally large secretion of gastric juice commonly occurs in the empty stomach of ulcer patients in the absence of any of the usual types of secretory stimuli and that this excessive secretion is neurogenic in origin.