D. Dewalque | Researchain

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Featured researches published by D. Dewalque.

European Journal of Pharmaceutical Sciences | 1998

Pyridothiadiazinedioxides structurally related to quinazolinones cholecystokinin/gastrin receptor ligands: synthesis and biological evaluation

Bernard Pirotte; Pascal De Tullio; T. Podona; Ousmane Diouf; D. Dewalque; Philippe Neven; Bernard Masereel; Daniel-Henri Caignard P; Pierre Renard; Jacques Delarge

The synthesis of 3-aralkyl-4-aryl-4H-, 3-aralkylamino-4-aryl-4H- and 3-aralkylsulfanyl-4-aryl-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1, 1-dioxides is described. Moreover, the affinity of the different compounds towards the cholecystokinin CCK-A and CCK-B receptors was evaluated. For selected compounds, affinity on the two receptor subtypes was expressed in the micromolar range. This was comparable to the affinity observed with the naturally occurring CCK receptor antagonist asperlicin.

Journal of Pharmacy and Pharmacology | 1997

Synthesis and biological evaluation of new 3-aralkylamino-2-aryl-2H-1,2,4-pyridothiadiazine 1,1-dioxides as potential CCK receptor ligands

Pascal De Tullio; Bernard Pirotte; Philippe Neven; Bernard Masereel; D. Dewalque; Ousmane Diouf; T. Podona; Daniel Henri Caignard; Pierre Renard; Jacques Delarge

A series of 2‐aralkyl‐4H‐pyridothiadiazine 1,1‐dioxides and 3‐aralkylamino‐2‐aryl‐2H‐pyrido[4,3‐e]‐1,2,4‐thiadiazine 1,1‐dioxides structurally related to quinazolinone CCK receptor antagonists were synthesized and evaluated as CCK‐A and CCK‐B receptor ligands.

Archive | 2004

Relaxant effects on the rat uterine smooth muscle of putative K+ATP channel openers

S. Boverie; Pascal De Tullio; S. Sebille; D. Dewalque; Jacques Damas; Pierre Lebrun; Bernard Pirotte

Archive | 2004

Synthèse de nouveaux analogues benzothiadiaziniques en tant qu’activateurs potentiels des canaux KATP et leur évaluation pharmacologique in vitro sur cellules B pancréatiques, aorte et utérus de rats

S. Boverie; M. H. Antoine; Pascal De Tullio; S. Sebille; D. Dewalque; Jacques Damas; Pierre Lebrun; Bernard Pirotte

Archive | 2002

Relaxant effects on the rat uterine smooth muscle of K+ATP channel openers compared to ritodrine, diltiazem and verapamil : development of new pharmacological in vitro models

S. Boverie; Pascal De Tullio; D. Dewalque; S. Sebille; Jacques Damas; Bernard Pirotte

Archive | 2002

Action myorelâchante sur la fibre musculaire lisse utérine de nouveaux dérivés de type 4H-1,2,4-benzothiadiazine 1,1-dioxyde diversement substitués en position 3 et 7

S. Boverie; D. Dewalque; S. Sebille; Jacques Damas; Bernard Pirotte; Pascal De Tullio

Fundamental & Clinical Pharmacology | 2002

Relaxant effect of K+ATP channel openers on the uterine smooth muscle: pharmacological in vitro models

Pascal De Tullio; S. Boverie; D. Dewalque; S. Sebille; Jacques Damas; Bernard Pirotte

Archive | 2001

Preparation and biological properties of chemically diverse 3-substituted 7-chloro-4H-1,2,4-benzothiadiazine 1,1-dioxides structurally related to the potassium channel opener diazoxide

S. Boverie; Pascal De Tullio; B. Becker; M. H. Antoine; D. Dewalque; Jacques Damas; Pierre Lebrun; Bernard Pirotte

Archive | 2001

Propriétés biologiques des 7-chloro-4H-1,2,4-benzothiadiazine 1,1-dioxydes diversement substitués en position 3: nouveaux analogues du diazoxide

S. Boverie; Pascal De Tullio; B. Becker; M. H. Antoine; D. Dewalque; Jacques Damas; Pierre Lebrun; Bernard Pirotte

Archive | 2000

Synthesis and biological evaluation of 3-alkylamino-7-chloro-4H-1,2,4-benzothiadiazine 1,1-dioxides as KATP channel openers structurally related to BPDZ 73

S. Boverie; B. Becker; F. Somers; Pascal De Tullio; D. Dewalque; M. H. Antoine; Per Arkhammar; F. E. Nielsen; John Bondo Hansen; Jacques Damas; J. Delarge; Pierre Lebrun; Bernard Pirotte

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