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S. Sebille

Université libre de Bruxelles

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Publication

Featured researches published by S. Sebille.

Expert Opinion on Therapeutic Patents | 2005

New insights into the development of ATP-sensitive potassium channel openers

Bernard Pirotte; Pascal De Tullio; Marie-Hélène Antoine; S. Sebille; Xavier Florence; Philippe Lebrun

ATP-sensitive potassium channel openers are expected to be valuable drugs for the treatment of a wide variety of pathologies. However, their clinical interest depends mainly on their tissue selectivity, which is linked to their affinity for a specific ATP-sensitive potassium (KATP) channel subtype. Hypertension was the first indication for KATP channel openers currently on the market. Recent progress in the synthesis of tissue-selective compounds led to the discovery of potential candidates for the management (prevention and/or treatment) of several pathological states such as Type 1 or Type 2 diabetes, obesity, urinary incontinence and congestive heart failure. The present report focuses on patent applications introduced between 2001 – 2004, describing original KATP channel openers.

Archive | 2005

Benzopyran derivatives, method of production and use thereof

S. Sebille; Bernard Pirotte; Stéphane Boverie; Pascal De Tullio; Philippe Lebrun; Marie-Hélène Antoine

Archive | 2005

Vers la découverte d’activateurs sélectifs du canal KATP pancréatique, analogues du cromakalim : synthèse et évaluation pharmacologique du R/S-4-(4-chlorophénylaminothiocarbonylamino)-3,4-dihydro-2,2-diméthyl-6-fluoro-2H-1-benzopyrane

S. Sebille; Xavier Florence; M. H. Antoine; S. Boverie; Pascal De Tullio; Pierre Lebrun; Bernard Pirotte

Archive | 2004

Utilisation de la spectrométrie RMN dans l’identification de structure de dérivés biotinylés de modulateurs de canaux potassiques ATP-dépendants

Pascal De Tullio; S. Sebille; Xavier Florence; Ph. Lebrun; Bernard Pirotte

Archive | 2004

Improvement of the pharmacophoric model for an agonistic activity of arylthiadiazine dioxides on pancreatic KATP channels using the CoMSIA approach

Pascal De Tullio; L. Dupont; S. Boverie; B. Becker; M. H. Antoine; S. Sebille; Pierre Lebrun; Bernard Pirotte

Archive | 2004

Relaxant effects on the rat uterine smooth muscle of putative K+ATP channel openers

S. Boverie; Pascal De Tullio; S. Sebille; D. Dewalque; Jacques Damas; Pierre Lebrun; Bernard Pirotte

Archive | 2004

Nouveaux activateurs des canaux KATP analogues du cromakalim : synthèse et évaluation pharmacologique in vitro sur cellules B pancréatiques et aortes de rats

S. Sebille; Pascal De Tullio; M. H. Antoine; S. Boverie; Pierre Lebrun; Bernard Pirotte

Archive | 2004

New analogues of the potassium channel opener cromakalim: effects on rat pancreatic B-cells and rat aorta rings

S. Sebille; Pascal De Tullio; M. H. Antoine; S. Boverie; Bernard Pirotte; Pierre Lebrun

Archive | 2004

Synthèse de nouveaux analogues benzothiadiaziniques en tant qu’activateurs potentiels des canaux KATP et leur évaluation pharmacologique in vitro sur cellules B pancréatiques, aorte et utérus de rats

S. Boverie; M. H. Antoine; Pascal De Tullio; S. Sebille; D. Dewalque; Jacques Damas; Pierre Lebrun; Bernard Pirotte

Fundamental & Clinical Pharmacology | 2004

New analogues of the KATP channel opener cromakalim : synthesis and pharmacological evaluation on rat pancreatic B-cells and rat aorta rings

S. Sebille; Pascal De Tullio; M. H. Antoine; S. Boverie; Pierre Lebrun; Bernard Pirotte

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Collaboration

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Bernard Pirotte

University of Liège

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Pascal De Tullio

University of Liège

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S. Boverie

University of Liège

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M. H. Antoine

Université libre de Bruxelles

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Pierre Lebrun

University of Liège

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B. Becker

Université libre de Bruxelles

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D. Dewalque

University of Liège

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Jacques Damas

University of Liège

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Philippe Lebrun

Université libre de Bruxelles

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Xavier Florence

University of Liège

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