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Daniel Bichon

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Publication

Featured researches published by Daniel Bichon.

Life Sciences | 1994

SR 142801, the first potent non-peptide antagonist of the tachykinin NK3 receptor.

X. Emonds-Alt; Daniel Bichon; Jean-Philippe Ducoux; Michel Héaulme; B. Miloux; Martine Poncelet; Vincenzo Proietto; D. Van Broeck; P. Vilain; Gervais Neliat; P. Soubrié; G. Le Fur; J.C. Brele`ere

SR 142801 is the first potent and selective non-peptide antagonist of the tachykinin NK3 receptor. It inhibited [MePhe7]NKB binding to its receptor from various species, including humans. SR 142801 was a competitive antagonist of [MePhe7]NKB-mediated contractions of guinea-pig ileum and inhibited the acetylcholine release following the activation of the guinea-pig ileum tachykinin NK3 receptor. In vivo, SR 142801 potently inhibited the turning behaviour induced by intrastriatal injection of senktide in gerbils, and appears as a powerful tool for investigation of the physiological and pathological role of NKB and its NK3 receptor.

European Journal of Pharmacology | 1993

In vitro and in vivo biological activities of SR140333, a novel potent non-peptide tachykinin NK1 receptor antagonist.

Xavier Emonds-Alt; Jean-Daniel Doutremepuich; Michel Héaulme; Gervais Neliat; Vincent Santucci; Régis Steinberg; P. Vilain; Daniel Bichon; Jean-Philippe Ducoux; Vincenzo Proietto; Didier Van Broeck; Philippe Soubrie; Gérard Le Fur; Jean-Claude Breliere

Archive | 1995

Novel N-(3,4-dichlorophenyl-propyl)-piperidine derivatives as selective human NK3-receptor antagonists

Daniel Bichon; Broeck Didier Van; Vincenzo Proietto; Patrick Gueule; Xavier Emonds-Alt

Archive | 1999

Compounds which are selective antagonists of the human nk3 receptor and their use as medicinal products and diagnostic tools

Daniel Bichon; Patrick Gueule; Didier Van Broeck; Xavier Emonds-Alt; Vincenzo Proietto

Archive | 1996

Human NK3 receptor-selective antagonist compounds, method for obtaining them and pharmaceutical compositions containing them

Daniel Bichon; Xavier Emonds-Alt; Patrick Gueule; Vincenzo Proietto; Didier Van Broeck

Archive | 1996

Human NK3 receptor-selective antagonist compounds, process for their obtention and pharmaceutical compositons containing them

Daniel Bichon; Xavier Edmonds-Alt; Patrick Gueule; Vincenzo Proietto; Broeck Didier Van

Archive | 1996

1-acyl-3-phenyl-3-(3-piperidinopropyl)piperidinderivate als für den menschlichen nk3-rezeptor selektive antagonisten 1-acyl-3-phenyl-3- (3-piperidinopropyl) piperidine derivatives as antagonists of the human NK3 receptor selective

Daniel Bichon; Xavier Edmonds-Alt; Patrick Gueule; Vincenzo Proietto; Broeck Didier Van

Archive | 1996

1-acyl-3-phenyl-3-(3-piperidinopropyl)piperidine derivatives as human nk3 receptor selective antagonists

Daniel Bichon; Xavier Edmonds-Alt; Patrick Gueule; Vincenzo Proietto; Broeck Didier Van

Archive | 1996

Nouveaux composes antagonistes selectifs du recepteur nk3 humain, procede pour leur obtention et compositions pharmaceutiques les contenant

Daniel Bichon; Xavier Edmonds-Alt; Patrick Gueule; Vincenzo Proietto; Broeck Didier Van

Archive | 1996

1-acyl-3-phenyl-3-(3-piperidinopropyl)piperidin-derivate als für den menschlichen nk3-rezeptor selektive antagonisten Piperidine derivatives as antagonists of the human NK3 receptor selective 1-acyl-3-phenyl-3- (3-piperidinopropyl)

Daniel Bichon; Xavier Edmonds-Alt; Patrick Gueule; Vincenzo Proietto; Broeck Didier Van

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Collaboration

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Xavier Emonds-Alt

University of Montpellier

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Gervais Neliat

Rhône-Poulenc

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G. Le Fur

Rhône-Poulenc

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Gérard Le Fur

Rhône-Poulenc

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P. Soubrié

University of Montpellier

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Vincent Santucci

Novartis

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