Daniel González-Vilas

Pigmented contact dermatitis due to kojic acid. A paradoxical side effect of a skin lightener.

Kojic acid (5-hydroxy-2-(hydroxymethyl)-4-pyrone; CAS 501-30-4) has been increasingly used as a skinlightening agent in cosmetic products. Despite it being considered to have high sensitizing potential (1), few cases of contact allergy have been reported in the literature (2, 3). We report a case of pigmented contact dermatitis to kojic acid. The clinical diagnosis and the histopathology of the lesions are briefly discussed. Case Report

Allergic contact dermatitis in a girl due to several cosmetics containing diazolidinyl-urea or imidazolidinyl-urea

Preservatives are among the most frequent causes of allergic contact dermatitis caused by cosmetics. Such products are needed to prevent microbial contamination, which may cause discoloration, malodours, and physical and chemical degradation (1). Formaldehyde-releasing preservatives are a group of substances that release formaldehyde as a result of decomposition (2). Diazolidinyl-urea, imidazolidinyl-urea, quaternium-15, DMDM hydantoin, and 2-bromo-2-nitropropane-1,3-diol are well-known examples frequently used in cosmetics. We present the case of a girl reacting to several products containing diazolidinyl-urea and/or imidazolidinyurea. Patch test results to formaldehyde and other formaldehyde releasers were negative.

Disseminated eruptive clear cell acanthoma with spontaneous regression: further evidence of an inflammatory origin?

Clear cell acanthoma (CCA) is a benign epidermal lesion with distinctive clinicopathological features. Multiple disseminated eruptive CCA is an infrequent clinical variant that has been rarely reported. It is characterized by the presence of more than 30 lesions from 1 to 10 mm in diameter that appear progressively over the years. We report the case of a 65-year-old woman with multiple disseminated eruptive CCA affecting her lower extremities. In contrast to previous reports, most of the lesions appeared in a short period of time (less than a month) and, what is more interesting is that some of them have regressed spontaneously leaving residual hyperpigmentation. At present, the histogenesis and etiology of CCA remain unknown. Accumulating data suggest a reactive origin associated with a variety of different inflammatory conditions. The case presented in this report further substantiates that CCA is indeed a reactive epidermal reaction pattern with an inflammatory etiology.

Viral-associated trichodysplasia secondary to antineoplastic treatment in a patient with lymphoblastic leukemia.

Viral-associated trichodysplasia spinulosa is an unusual condition with distinctive clinical and histopathological features. Initially described in patients immunosupressed as a result of solid organ transplantation, it has also been reported in patients treated with immunosuppressive drugs other than cyclosporine or being treated for hematological malignancies. Patients presented with disseminated follicular, hyperkeratotic papules, and variable degrees of alopecia. Histopathological examination revealed shaftless bulbous and dilated hair follicles with keratotic plugging of the infundibulum. The authors reported a case of viral-associated trichodysplasia in a 5-year-old boy treated for a lymphoblastic leukemia. Eruption persisted, although treated with emollients and keratolytics, but resolved spontaneously after completing the antineoplastic medication.

Ulcerated dermatofibroma with osteoclast-like giant cells

Background: Ulceration and osteoclast‐like giant cells are two pathological features uncommonly seen in dermatofibromas. To our knowledge, the presence of these features has not been previously described within the same lesion.

Enfermedad de Grover en fracaso renal crónico

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