Daniel H. Deon
Bristol-Myers Squibb
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Publication
Featured researches published by Daniel H. Deon.
Journal of General Virology | 2011
Dike Qiu; Julie A. Lemm; Donald R. O’Boyle; Jin-Hua Sun; Peter T. Nower; Van N. Nguyen; Lawrence G. Hamann; Lawrence B. Snyder; Daniel H. Deon; Edward H. Ruediger; Nicholas A. Meanwell; Makonen Belema; Min Gao; Robert A. Fridell
Hepatitis C virus (HCV) non-structural protein 5A (NS5A) is a multi-functional protein that is expressed in basally phosphorylated (p56) and in hyperphosphorylated (p58) forms. NS5A phosphorylation has been implicated in regulating multiple aspects of HCV replication. We recently reported the identification of a class of compounds that potently inhibit HCV RNA replication by targeting NS5A. Although the precise mechanism of inhibition of these compounds is not well understood, one activity that has been described is their ability to block expression of the hyperphosphorylated form of NS5A. Here, we report that an NS5A inhibitor impaired hyperphosphorylation without affecting basal phosphorylation at the C-terminal region of NS5A. This inhibitor activity did not require NS5A domains II and III and was distinct from that of a cellular kinase inhibitor that also blocked NS5A hyperphosphorylation, results that are consistent with an inhibitor-binding site within the N-terminal region of NS5A. In addition, we observed that an NS5A inhibitor promoted the accumulation of an HCV polyprotein intermediate, suggesting that inhibitor binding to NS5A may occur prior to the completion of polyprotein processing. Finally, we observed that NS5A p56 and p58 separated into different membrane fractions during discontinuous sucrose gradient centrifugation, consistent with these NS5A phosphoforms performing distinct replication functions. The p58 localization pattern was disrupted by an NS5A inhibitor. Collectively, our results suggest that NS5A inhibitors probably impact several aspects of HCV expression and regulation. These findings may help to explain the exceptional potency of this class of HCV replication complex inhibitors.
Archive | 2003
Tao Wang; John F. Kadow; Nicholas A. Meanwell; Kap-Sun Yeung; Zhongxing Zhang; Zhiwei Yin; Zhilei Qiu; Daniel H. Deon; Clint A. James; Edward H. Ruediger; Carol Bachand
Archive | 2009
Carol Bachand; Makonen Belema; Daniel H. Deon; Andrew C. Good; Jason Goodrich; Clint A. James; Rico Lavoie; Omar D. Lopez; Alain Martel; Nicholas A. Meanwell; Van N. Nguyen; Jeffrey L. Romine; Edward H. Ruediger; Lawrence B. Snyder; R Laurent Denis; Fukang Yang; David R. Langley; Gan Wang; Lawrence G. Hamann
Archive | 2008
Carol Bachand; Makonen Belema; Daniel H. Deon; Andrew C. Good; Jason Goodrich; Clint A. James; Rico Lavoie; Omar D. Lopez; Alain Martel; Nicholas A. Meanwell; Van N. Nguyen; Jeffrey L. Romine; Edward H. Ruediger; Lawrence B. Snyder; R Laurent Denis; Fukang Yang; David R. Langley; Gan Wang; Lawrence G. Hamann
Archive | 2009
Carol Bachand; Belema Makonen; Daniel H. Deon; Andrew C. Good; Jason Goodrich; Clint A. James; Rico Lavoie; Omar D. Lopez; Alain Martel; Nicholas A. Meanwell; Van N. Nguyen; Jeffrey L. Romine; Edward H. Ruediger; Lawrence B. Snyder; R Laurent Denis; Fukang Yang; David R. Langley; Gan Wang; Lawrence G. Hamann
Archive | 2013
Michael R Lawrence; Michael M. Miller; Dietmar Seiffert; Shoshana Posy; Pancras C. Wong; Jacques Banville; Edward H. Ruediger; Daniel H. Deon; Alain Martel; François Tremblay; Julia Guy; Jean-Francois Lavallee; Marc Gagnon
Archive | 2005
Edward H. Ruediger; Daniel H. Deon; John F. Kadow
Archive | 2007
Carol Bachand; Daniel H. Deon; Edward H. Ruediger
Archive | 2017
Alain Martel; Daniel H. Deon; Dietmar A. Seiffert; Edward H. Ruediger; François Tremblay; Jacques Banville; Jean François Lavallee; Julia Guy; Marc Gagnon; Michael M. Miller; Michael R Lawrence; Pancras C. Wong; Shoshana Posy
Archive | 2017
Brad D. Maxwell; Daniel H. Deon; Edward H. Ruediger; Eldon Scott Priestley; Jacques Banville; Julia Guy; Laurence Dube; Marc Gagnon; Michael M. Miller; Michael R Lawrence; Pancras C. Wong; Roger Remillard; Shoshana Posy