Daniel James Koch | Researchain

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Featured researches published by Daniel James Koch.

Bioorganic & Medicinal Chemistry Letters | 2003

Advances toward new antidepressants beyond SSRIs: 1-aryloxy-3-piperidinylpropan-2-ols with dual 5-HT1A receptor antagonism/SSRI activities. Part 3

Kumiko Takeuchi; Todd J. Kohn; Nicholas Allan Honigschmidt; Vincent Patrick Rocco; Patrick Gianpietro Spinazze; Daniel James Koch; Steven T Atkinson; Larry Wayne Hertel; David L. Nelson; D.Bradley Wainscott; Laura J Ahmad; Janice Shaw; David T. Wong

A series of 1-aryloxy-3-piperidinylpropan-2-ols possessing potent dual 5-HT(1A) receptor antagonism and serotonin reuptake inhibition was discovered. 1-(1H-Indol-4-yloxy)-3-(4-benzo[b]thiophen-2-ylpiperidinyl)propan-2-ols exhibited selective and high affinity at the 5-HT(1A) receptor and serotonin reuptake inhibition at nanomolar concentrations for dual activities.

Federation proceedings | 1997

Inhibition of serotonin reuptake

James E. Audia; Daniel James Koch; Thomas Edward Mabry; Jeffrey S. Nissen; Vincent Patrick Rocco; Yao-Chang Xu

Archive | 1999

5-ht1f agonists

Sandra Ann Filla; Daniel James Koch; Brian Michael Mathes; Vincent Patrick Rocco

Archive | 1996

5-substituted-3-(1,2,3,6-tetrahydropyridin-4-yl)-and 3-(piperidin-4-yl)-1h-indoles: new 5-ht1f agonists

James E. Audia; Bruce A. Dressman; James J. Droste; James Erwin Fritz; Stephen W. Kaldor; Daniel James Koch; Joseph H. Krushinski; Jeffrey S. Nissen; Vincent Patrick Rocco; John Mehnert Schaus; Dennis Charles Thompson

Archive | 1997