Daniel Martin Retz | Researchain

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Featured researches published by Daniel Martin Retz.

Bioorganic & Medicinal Chemistry Letters | 2008

4-Aminopyrimidine tetrahydronaphthols : A series of novel vanilloid receptor-1 antagonists with improved solubility properties

Elizabeth M. Doherty; Daniel Martin Retz; Narender R. Gavva; Rami Tamir; James J. S. Treanor; Mark H. Norman

8-(6-(4-(Trifluoromethyl)phenyl)pyrimidin-4-ylamino)-1,2,3,4-tetrahydronaphthalen-2-ol (4) and analogs (5-10) were shown to be potent inhibitors of human and rat TRPV1 in vitro with increased solubility over our previous series. Synthesis, SAR, and improvements in metabolic stability and absorption of these compounds are described herein.

Journal of Medicinal Chemistry | 2000

Fenchylamine sulfonamide inhibitors of amyloid β peptide production by the γ-secretase proteolytic pathway : Potential small-molecule therapeutic agents for the treatment of alzheimer's disease

Gilbert M. Rishton; Daniel Martin Retz; Paul A. Tempest; James Novotny; Steve Kahn; James J. S. Treanor; Jack Lile; Martin Citron

Archive | 2006

Nitrogen- containing bicyclic hetroaryl compounds for the treatment of raf protein kinase-mediated diseases

Morin Frenel F. De; Jian J. Chen; Elizabeth M. Doherty; Stephen A. Hitchcock; Qi Huang; Joseph L. Kim; Gang Liu; Thomas Nixey; Nick A. Paras; Jeffrey Petkus; Daniel Martin Retz; Adrian L. Smith; Andrew Tasker; Jiawang Zhu

Archive | 2005

Aminopyrimidine compounds and methods of use

Adrian L. Smith; Paul Edward Brennan; Frenel DeMorin; Gang Liu; Nick A. Paras; Daniel Martin Retz; Elizabeth Rainbeau

Archive | 2006

Nitrogen-containing bicyclic heteroaryl compounds and methods of use

Frenel F. De Morin; Jian J. Chen; Elizabeth M. Doherty; Stephen A. Hitchcock; Qi Huang; Joseph L. Kim; Gang Liu; Thomas Nixey; Nick A. Paras; Jeffrey Petkus; Daniel Martin Retz; Adrian L. Smith; Andrew Tasker; Jiawang Zhu

Archive | 2011

Substituted pyrimidine compounds as RAF inhibitors and methods of use

Archive | 2006

Composes d'heteroaryle bicycliques azotes et procedes d'utilisation

Jian J. Chen; Morin Frenel F. De; Elizabeth M. Doherty; Stephen A. Hitchcock; Qi Huang; Joseph L. Kim; Gang Liu; Thomas Nixey; Nick A. Paras; Jeffrey Petkus; Daniel Martin Retz; Adrian L. Smith; Andrew Tasker; Jiawang Zhu

Archive | 2005