Daniel Schwarz
University of Zurich
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Featured researches published by Daniel Schwarz.
Development | 2014
Daniel Schwarz; Sandra Varum; Martina Zemke; Anne Schöler; Arianna Baggiolini; Kalina Draganova; Haruhiko Koseki; Dirk Schübeler; Lukas Sommer
The emergence of craniofacial skeletal elements, and of the jaw in particular, was a crucial step in the evolution of higher vertebrates. Most facial bones and cartilage are generated during embryonic development by cranial neural crest cells, while an osteochondrogenic fate is suppressed in more posterior neural crest cells. Key players in this process are Hox genes, which suppress osteochondrogenesis in posterior neural crest derivatives. How this specific pattern of osteochondrogenic competence is achieved remains to be elucidated. Here we demonstrate that Hox gene expression and osteochondrogenesis are controlled by epigenetic mechanisms. Ezh2, which is a component of polycomb repressive complex 2 (PRC2), catalyzes trimethylation of lysine 27 in histone 3 (H3K27me3), thereby functioning as transcriptional repressor of target genes. Conditional inactivation of Ezh2 does not interfere with localization of neural crest cells to their target structures, neural development, cell cycle progression or cell survival. However, loss of Ezh2 results in massive derepression of Hox genes in neural crest cells that are usually devoid of Hox gene expression. Accordingly, craniofacial bone and cartilage formation is fully prevented in Ezh2 conditional knockout mice. Our data indicate that craniofacial skeleton formation in higher vertebrates is crucially dependent on epigenetic regulation that keeps in check inhibitors of an osteochondrogenic differentiation program.
Archive | 2014
Michael Erne; Jan Fivaz; Daniel Schwarz
In the wake of the financial crisis, budgetary discipline has taken centre stage in politics. More than ever a countrys budget mirrors the true policy preferences of the legislative majority beyond all political discourse and cheap talk. The paper sheds light on mandate fulfilment in the field of public spending and fiscal policy in general. Based on previous work on pledge fulfilment in Switzerland the paper compares publicised pre-electoral statements of MPs on public spending and the development of the public finances with their post-electoral legislative behaviour during budget debates and votes. The findings of the paper confirm the results of the aforementioned earlier studies and point to the potential of budgetary statements for future mandate fulfilment research.
Swiss Political Science Review | 2010
Daniel Schwarz; Lisa Schädel; Andreas Ladner
Ladner, Andreas; Schwarz, Daniel; Fivaz, Jan (2008). Die Positionierung der Nationalratskandidierenden 2007. Eine explorative Analyse der Antworten auf die Fragen der Online-Wahlhilfe smartvote. Cahier de l'IDHEAP: Vol. 243. Chavannes-près-Renens: IDHEAP | 2008
Andreas Ladner; Daniel Schwarz; Jan Fivaz
Archive | 2014
Jan Fivaz; Tom Louwerse; Daniel Schwarz
Archive | 2016
Daniel Schwarz; Lisa Schädel Stojanovic; Andreas Ladner
Archive | 2015
Daniel Schwarz; Jan Fivaz
Schwarz, Daniel; Fivaz, Jan (11 May 2014). Wie radikal sind die Schweizer Parteien? Ein europäischer Vergleich bringt Überraschendes an den Tag. watson.ch | 2014
Daniel Schwarz; Jan Fivaz
Archive | 2014
Daniel Schwarz; Reto Steiner; Jan Fivaz
Archive | 2010
Daniel Schwarz; Lisa Schädel; Andreas Ladner