Daniel Vanna Siev
Dendreon
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Publication
Featured researches published by Daniel Vanna Siev.
Bioorganic & Medicinal Chemistry Letters | 2000
J. Edward Semple; Odile E. Levy; Nathaniel K. Minami; Timothy D. Owens; Daniel Vanna Siev
Judicious combination of P-region sequences of highly potent anticoagulant proteins including NAP5, NAP6, Ecotin, and Antistasin with SAR from small molecule FXa inhibitors led to a series of chimeric inhibitors of formula 1a-j. We report herein the design, synthesis, and biological activity of this novel family of FXa inhibitors that express both high in vitro potency and superb selectivity against related serine proteases.
Tetrahedron Letters | 1999
Daniel Vanna Siev; John Gaudette; J. Edward Semple
The design, synthesis and application of novel argininal aminals 1 tethered onto AM resin is described. Efficient solid-phase synthesis routes to a wide array of the title derivatives 2 have been implemented using this convenient technology. The resulting P1-argininal targets serve as useful exploratory scaffolds for serine and cysteine protease inhibitor discovery.
Archive | 2002
Edwin L. Madison; Joseph Edward Semple; George P. Vlasuk; Scott Jeffrey Kemp; Mallareddy Komandla; Daniel Vanna Siev
Bioorganic & Medicinal Chemistry Letters | 2002
Jingrong Jean Cui; Gian-Luca Araldi; John Reiner; Komandla Malla Reddy; Scott Jeffrey Kemp; Jonathan Z. Ho; Daniel Vanna Siev; Lala Mamedova; Tony S. Gibson; John Gaudette; Nathaniel K. Minami; Susanne M Anderson; Annette E Bradbury; Thomas G. Nolan; J. Edward Semple
Archive | 1998
Daniel Vanna Siev; J. Edward Semple; Michael I. Weinhouse
Archive | 2000
Daniel Vanna Siev; Gian Luca Araldi; Jonathan Z. Ho; John Reiner; Joseph Edward Semple
Archive | 2001
Daniel Vanna Siev; Joseph Edward Semple; Mallareddy Komandla; John Reiner; Scott Jeffrey Kemp
Archive | 2001
Daniel Vanna Siev; Joseph Edward Semple; Mallareddy Komandla; John Reiner; Scott Jeffrey Kemp
Archive | 2001
Joseph Edward Semple; Jingjong Jean Cui; Jonathan Zhangi Ho; Odile Esther Levy; Gian Luca Araldi; John Reiner; Daniel Vanna Siev
Archive | 1999
Daniel Vanna Siev; J. Edward Semple; Michael I. Weinhouse