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Dive into the research topics where Daniel Vanna Siev is active.

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Featured researches published by Daniel Vanna Siev.


Bioorganic & Medicinal Chemistry Letters | 2000

Novel, potent and selective chimeric FXa inhibitors featuring hydrophobic P1-ketoamide moieties.

J. Edward Semple; Odile E. Levy; Nathaniel K. Minami; Timothy D. Owens; Daniel Vanna Siev

Judicious combination of P-region sequences of highly potent anticoagulant proteins including NAP5, NAP6, Ecotin, and Antistasin with SAR from small molecule FXa inhibitors led to a series of chimeric inhibitors of formula 1a-j. We report herein the design, synthesis, and biological activity of this novel family of FXa inhibitors that express both high in vitro potency and superb selectivity against related serine proteases.


Tetrahedron Letters | 1999

NOVEL PROTOCOL FOR THE SOLID-PHASE SYNTHESIS OF PEPTIDYL AND PEPTIDOMIMETIC P1-ARGININAL DERIVATIVES

Daniel Vanna Siev; John Gaudette; J. Edward Semple

The design, synthesis and application of novel argininal aminals 1 tethered onto AM resin is described. Efficient solid-phase synthesis routes to a wide array of the title derivatives 2 have been implemented using this convenient technology. The resulting P1-argininal targets serve as useful exploratory scaffolds for serine and cysteine protease inhibitor discovery.


Archive | 2002

Conjugates activated by cell surface proteases and therapeutic uses thereof

Edwin L. Madison; Joseph Edward Semple; George P. Vlasuk; Scott Jeffrey Kemp; Mallareddy Komandla; Daniel Vanna Siev


Bioorganic & Medicinal Chemistry Letters | 2002

Non-covalent thrombin inhibitors featuring P3-heterocycles with P1-bicyclic arginine surrogates.

Jingrong Jean Cui; Gian-Luca Araldi; John Reiner; Komandla Malla Reddy; Scott Jeffrey Kemp; Jonathan Z. Ho; Daniel Vanna Siev; Lala Mamedova; Tony S. Gibson; John Gaudette; Nathaniel K. Minami; Susanne M Anderson; Annette E Bradbury; Thomas G. Nolan; J. Edward Semple


Archive | 1998

Resin derivatization method and uses thereof

Daniel Vanna Siev; J. Edward Semple; Michael I. Weinhouse


Archive | 2000

Non-covalent thrombin inhibitors

Daniel Vanna Siev; Gian Luca Araldi; Jonathan Z. Ho; John Reiner; Joseph Edward Semple


Archive | 2001

Novel non-convalent thrombin inhibitors

Daniel Vanna Siev; Joseph Edward Semple; Mallareddy Komandla; John Reiner; Scott Jeffrey Kemp


Archive | 2001

Non-convalent thrombin inhibitors

Daniel Vanna Siev; Joseph Edward Semple; Mallareddy Komandla; John Reiner; Scott Jeffrey Kemp


Archive | 2001

Pyridine and pyrazine derivatives as thrombin inhibitors

Joseph Edward Semple; Jingjong Jean Cui; Jonathan Zhangi Ho; Odile Esther Levy; Gian Luca Araldi; John Reiner; Daniel Vanna Siev


Archive | 1999

Procede de derivatisation d'une resine et utilisations du produit obtenu

Daniel Vanna Siev; J. Edward Semple; Michael I. Weinhouse

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J. Edward Semple

University of Pennsylvania

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Edwin L. Madison

Scripps Research Institute

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Komandla Malla Reddy

University of Texas Southwestern Medical Center

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