Daniela de Oliveira Werneck Rodrigues
Universidade Federal de Juiz de Fora
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Revista Brasileira De Hematologia E Hemoterapia | 2013
Adriana Aparecida Ferreira; Maria Teresa Bustamante-Teixeira; Isabel Cristina Gonçalves Leite; Camila Soares Lima Corrêa; Daniela de Oliveira Werneck Rodrigues; Danielle Teles da Cruz
Background Hemophilia is a potentially disabling condition as hemophilic arthropathy develops early in life and is progressive, especially in patients treated in an on-demand regime. Objective This study aimed to describe the structural joint status and the functional independence score of hemophiliac adults and correlate structural damage with the functional deficits found in these patients. Methods Hemophiliacs at the Juiz de Fora Regional Blood Center - HEMOMINAS Foundation, aged 18 years and over and treated in an on-demand regime, were clinically evaluated in respect to structural joint damage using the World Federation of Hemophilia Physical Examination Scale (WFH-PE) and functional deficits using the Functional Independence Score in Hemophilia (FISH). The Spearman rank test was used to evaluate the correlation between the two scores. Results Thirty-nine patients were evaluated. The mean age was 36.8 years. Target joints were detected in 69.2% of patients studied. The mean Physical Examination Scale and Functional Independence Score were 16.87 and 25.64, respectively. Patients with mild hemophilia showed no significant joint involvement. Patients with severe or moderate hemophilia had similar results regarding structural damage (p-value < 0.001) and functional deficits (p-value = 0.001). There was statistical significance in the correlation between the two scores (r = -0.850; p-value = 0.01). Conclusions The World Federation of Hemophilia Physical Examination Scale and Functional Independence Score in Hemophilia may be useful to clinically assess structural joint damage and functional deficits in hemophiliacs as the tools are inexpensive and easy to administer and may be able to detect hemophilic arthropathy, which results from recurrent hemarthrosis and is common in the population studied.
Jornal De Pediatria | 2016
Daniela de Oliveira Werneck Rodrigues; Luiz Cláudio Ribeiro; Lysla C. Sudário; Maria Teresa Bustamante Teixeira; Marina L. Martins; Anuska M.O.L. Pittella; Irtis de O. Fernandes Junior
Objective To verify genetic determinants associated with stroke in children with sickle cell disease (SCD).OBJECTIVE To verify genetic determinants associated with stroke in children with sickle cell disease (SCD). METHODS Prospective cohort with 110 children submitted to neonatal screening by the Neonatal Screening Program, between 1998 and 2007, with SCD diagnosis, followed at a regional reference public service for hemoglobinopathies. The analyzed variables were type of hemoglobinopathy, gender, coexistence with alpha thalassemia (α-thal), haplotypes of the beta globin chain cluster, and stroke. The final analysis was conducted with 66 children with sickle cell anemia (SCA), using the chi-squared test in the program SPSS® version 14.0. RESULTS Among children with SCD, 60% had SCA. The prevalence of coexistence with α-thal was 30.3% and the Bantu haplotype (CAR) was identified in 89.2%. The incidence of stroke was significantly higher in those with SCA (27.3% vs. 2.3%; p=0.001) and males (24.1% vs. 9.6%; p=0.044). The presence of α-thal (p=0.196), the CAR haplotype (p=0.543), and socioeconomic factors were not statistically significant in association with the occurrence of stroke. CONCLUSION There is a high incidence of stroke in male children and in children with SCA. Coexistence with α-thal and haplotypes of the beta globin chain cluster did not show any significant association with stroke. The heterogeneity between previously evaluated populations, the non-reproducibility between studies, and the need to identify factors associated with stroke in patients with SCA indicate the necessity of conducting further research to demonstrate the relevance of genetic factors in stroke related to SCD.
Jornal De Pediatria | 2016
Daniela de Oliveira Werneck Rodrigues; Luiz Cláudio Ribeiro; Lysla C. Sudário; Maria Teresa Bustamante Teixeira; Marina L. Martins; Anuska M.O.L. Pittella; Irtis de O. Fernandes Junior
Objective To verify genetic determinants associated with stroke in children with sickle cell disease (SCD).OBJECTIVE To verify genetic determinants associated with stroke in children with sickle cell disease (SCD). METHODS Prospective cohort with 110 children submitted to neonatal screening by the Neonatal Screening Program, between 1998 and 2007, with SCD diagnosis, followed at a regional reference public service for hemoglobinopathies. The analyzed variables were type of hemoglobinopathy, gender, coexistence with alpha thalassemia (α-thal), haplotypes of the beta globin chain cluster, and stroke. The final analysis was conducted with 66 children with sickle cell anemia (SCA), using the chi-squared test in the program SPSS® version 14.0. RESULTS Among children with SCD, 60% had SCA. The prevalence of coexistence with α-thal was 30.3% and the Bantu haplotype (CAR) was identified in 89.2%. The incidence of stroke was significantly higher in those with SCA (27.3% vs. 2.3%; p=0.001) and males (24.1% vs. 9.6%; p=0.044). The presence of α-thal (p=0.196), the CAR haplotype (p=0.543), and socioeconomic factors were not statistically significant in association with the occurrence of stroke. CONCLUSION There is a high incidence of stroke in male children and in children with SCA. Coexistence with α-thal and haplotypes of the beta globin chain cluster did not show any significant association with stroke. The heterogeneity between previously evaluated populations, the non-reproducibility between studies, and the need to identify factors associated with stroke in patients with SCA indicate the necessity of conducting further research to demonstrate the relevance of genetic factors in stroke related to SCD.
Revista Brasileira De Hematologia E Hemoterapia | 2013
Adriana Aparecida Ferreira; Isabel Cristina Gonçalves Leite; Maria Teresa Bustamante-Teixeira; Camila Soares Lima Corrêa; Danielle Teles da Cruz; Daniela de Oliveira Werneck Rodrigues; Mônica Calil Borges Ferreira
EntomoBrasilis | 2012
Rafael Santos de Azevedo; Leandro Lourenço Dumas; Daniela de Oliveira Werneck Rodrigues; Carla Ferreira Rezende; Érica Pellegrini Caramaschi; Rosana Mazzoni; Jorge Luiz Nessimian
Revista de APS | 2010
Daniela de Oliveira Werneck Rodrigues; Mônica Calil Borges Ferreira; Patrícia Montesi Pereira; Maria Teresa Teixeira Bustamante; Estela Márcia Saraiva Campos; Carlos Marcelino de Oliveira
Revista Brasileira De Hematologia E Hemoterapia | 2008
Daniela de Oliveira Werneck Rodrigues; Anna Bárbara F. C. Proietti; Júnia Guimarães Mourão Cioffi
Revista de APS | 2016
Daniela de Oliveira Werneck Rodrigues; Lysla C. Sudário; Luiz Cláudio Ribeiro; Felipe Affonsêca Pedreira; Mônica de Albuquerque Costa; Irtis de O. Fernandes Junior; Anuska M.O.L. Pittella
HU Revista | 2015
Daniela de Oliveira Werneck Rodrigues; Luiz Oscar Machado Martins; Felipe Affonsêca Pedreira; Carlos Marcelino de Oliveira; Mônica de Albuquerque Costa; Luiz Cláudio Ribeiro
Gerais: Revista de Saúde Pública do SUS/MG | 2013
Daniela de Oliveira Werneck Rodrigues; Maria Teresa Bustamante Teixeira; Mônica Calil Borges Ferreira; Luiz Cláudio Ribeiro; Marina L. Martins; Estela Márcia Saraiva Campos; Patrícia Montesi Pereira; Gabriel C. Ribeiro