Darwin R. Labarthe
Northwestern University
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Featured researches published by Darwin R. Labarthe.
Circulation | 2010
Donald M. Lloyd-Jones; Yuling Hong; Darwin R. Labarthe; Dariush Mozaffarian; Lawrence J. Appel; Linda Van Horn; Kurt J. Greenlund; Stephen R. Daniels; Graham Nichol; Gordon F. Tomaselli; Donna K. Arnett; Gregg C. Fonarow; P. Michael Ho; Michael S. Lauer; Frederick A. Masoudi; Rose Marie Robertson; Véronique L. Roger; Lee H. Schwamm; Paul D. Sorlie; Clyde W. Yancy; Wayne D. Rosamond
This document details the procedures and recommendations of the Goals and Metrics Committee of the Strategic Planning Task Force of the American Heart Association, which developed the 2020 Impact Goals for the organization. The committee was charged with defining a new concept, cardiovascular health, and determining the metrics needed to monitor it over time. Ideal cardiovascular health, a concept well supported in the literature, is defined by the presence of both ideal health behaviors (nonsmoking, body mass index <25 kg/m2, physical activity at goal levels, and pursuit of a diet consistent with current guideline recommendations) and ideal health factors (untreated total cholesterol <200 mg/dL, untreated blood pressure <120/<80 mm Hg, and fasting blood glucose <100 mg/dL). Appropriate levels for children are also provided. With the use of levels that span the entire range of the same metrics, cardiovascular health status for the whole population is defined as poor, intermediate, or ideal. These metrics will be monitored to determine the changing prevalence of cardiovascular health status and define achievement of the Impact Goal. In addition, the committee recommends goals for further reductions in cardiovascular disease and stroke mortality. Thus, the committee recommends the following Impact Goals: “By 2020, to improve the cardiovascular health of all Americans by 20% while reducing deaths from cardiovascular diseases and stroke by 20%.” These goals will require new strategic directions for the American Heart Association in its research, clinical, public health, and advocacy programs for cardiovascular health promotion and disease prevention in the next decade and beyond.
Circulation | 2012
Paul K. Whelton; Lawrence J. Appel; Ralph L. Sacco; Cheryl A.M. Anderson; Elliott M. Antman; Norman R.C. Campbell; Sandra B. Dunbar; Edward D. Frohlich; John E. Hall; Mariell Jessup; Darwin R. Labarthe; Graham A. MacGregor; Frank M. Sacks; Jeremiah Stamler; Dorothea K. Vafiadis; Linda Van Horn
Recent reports of selected observational studies and a meta-analysis have stirred controversy and have become the impetus for calls to abandon recommendations for reduced sodium intake by the US general population. A detailed review of these studies documents substantial methodological concerns that limit the usefulness of these studies in setting, much less reversing, dietary recommendations. Indeed, the evidence base supporting recommendations for reduced sodium intake in the general population remains robust and persuasive. The American Heart Association is committed to improving the health of all Americans through implementation of national goals for health promotion and disease prevention, including its recommendation to reduce dietary sodium intake to <1500 mg/d.
Annals of Neurology | 2011
Mary G. George; Xin Tong; Elena V. Kuklina; Darwin R. Labarthe
The aim of this study was to determine acute stroke hospitalization rates for children and young adults and the prevalence of stroke risk factors among children and young adults hospitalized for acute stroke.
Bulletin of The World Health Organization | 2010
Simon Capewell; Earl S. Ford; Janet B. Croft; Julia Critchley; Kurt J. Greenlund; Darwin R. Labarthe
OBJECTIVEnTo examine the potential for reducing cardiovascular risk factors in the United States of America enough to cause age-adjusted coronary heart disease (CHD) mortality rates to drop by 20% (from 2000 baseline figures) by 2010, as targeted under the Healthy People 2010 initiative.nnnMETHODSnUsing a previously validated, comprehensive CHD mortality model known as IMPACT that integrates trends in all the major cardiovascular risk factors, stratified by age and sex, we calculated how much CHD mortality would drop between 2000 and 2010 in the projected population of the United States aged 25-84 years (198 million). We did this for three assumed scenarios: (i) if recent risk factor trends were to continue to 2010; (ii) success in reaching all the Healthy People 2010 risk factor targets, and (iii) further drops in risk factors, to the levels already seen in the low-risk stratum.nnnFINDINGSnIf age-adjusted CHD mortality rates observed in 2000 remained unchanged, some 388,000 CHD deaths would occur in 2010. First scenario: if recent risk factor trends continued to 2010, there would be approximately 19,000 fewer deaths than in 2000. Although improved total cholesterol, lowered blood pressure in men, decreased smoking and increased physical activity would account for some 51,000 fewer deaths, these would be offset by approximately 32,000 additional deaths from adverse trends in obesity and diabetes and in blood pressure in women. Second scenario: If Healthy People 2010 cardiovascular risk factor targets were reached, approximately 188,000 CHD deaths would be prevented. Scenario three: If the cardiovascular risk levels of the low-risk stratum were reached, approximately 372,000 CHD deaths would be prevented.nnnCONCLUSIONnAchievement of the Healthy People 2010 cardiovascular risk factor targets would almost halve the predicted CHD death rates. Additional reductions in major risk factors could prevent or postpone substantially more deaths from CHD.
Circulation | 2013
Thomas A. Pearson; Latha Palaniappan; Nancy T. Artinian; Mercedes R. Carnethon; Michael H. Criqui; Stephen R. Daniels; Gregg C. Fonarow; Stephen P. Fortmann; Barry A. Franklin; James M. Galloway; David C. Goff; Gregory W. Heath; Ariel T.H. Frank; Penny M. Kris-Etherton; Darwin R. Labarthe; Joanne M. Murabito; Ralph L. Sacco; Comilla Sasson; Melanie B. Turner
The goal of this American Heart Association Guide for Improving Cardiovascular Health at the Community Level (AHA Community Guide) is to provide a comprehensive inventory of evidence-based goals, strategies, and recommendations for cardiovascular disease (CVD) and stroke prevention that can be implemented on a community level. This guide advances the 2003 AHA Community Guide1 and the 2005 AHA statement on guidance for implementation2 by incorporating new evidence for community interventions gained over the past decade, expanding the target audience to include a broader range of community advocates, aligning with the concepts and terminology of the AHA 2020 Impact Goals, and recognizing the contributions of new public and private sector programs involving community interventions.nnIn recent years, expanding arrays of programs and policies have been implemented in increasingly diverse communities to provide tools, strategies, and other best practices to potentially reduce the incidence of initial and recurrent cardiovascular events. The AHA Community Guide complements the AHA statement entitled “Population Approaches to Improve Diet, Physical Activity, and Smoking Habits”3 and supports the AHA 2020 goal4 to “improve the cardiovascular health of all Americans by 20%, while reducing deaths from CVDs and stroke by 20%.” The present AHA Community Guide supports the AHA 2020 goal by identifying exemplary regional or national programs that encourage cardiovascular health behaviors and health factors (formerly addressing risk behaviors and risk factors) from which communities might acquire proven strategies, expertise, and technical assistance for improving cardiovascular health.nnThe AHA Community Guide seeks to prevent the onset of disease (primary prevention) and to maintain optimal cardiovascular health (primordial prevention) among broader segments of the population. Prior research indicates that using public health strategies such as sodium reduction in processed foods to lower blood pressure,5–8 tobacco laws to promote smoking cessation,9–11 and modification of …
Psychological Science | 2015
Johannes C. Eichstaedt; Hansen Andrew Schwartz; Margaret L. Kern; Gregory Park; Darwin R. Labarthe; Raina M. Merchant; Sneha Jha; Megha Agrawal; Lukasz Dziurzynski; Maarten Sap; Christopher Weeg; Emily E. Larson; Lyle H. Ungar; Martin E. P. Seligman
Hostility and chronic stress are known risk factors for heart disease, but they are costly to assess on a large scale. We used language expressed on Twitter to characterize community-level psychological correlates of age-adjusted mortality from atherosclerotic heart disease (AHD). Language patterns reflecting negative social relationships, disengagement, and negative emotions—especially anger—emerged as risk factors; positive emotions and psychological engagement emerged as protective factors. Most correlations remained significant after controlling for income and education. A cross-sectional regression model based only on Twitter language predicted AHD mortality significantly better than did a model that combined 10 common demographic, socioeconomic, and health risk factors, including smoking, diabetes, hypertension, and obesity. Capturing community psychological characteristics through social media is feasible, and these characteristics are strong markers of cardiovascular mortality at the community level.
Journal of the American College of Cardiology | 2009
Rita F. Redberg; Emelia J. Benjamin; Vera Bittner; Lynne T. Braun; David C. Goff; Stephen Havas; Darwin R. Labarthe; Marian C. Limacher; Donald M. Lloyd-Jones; Samia Mora; Thomas A. Pearson; Martha J. Radford; Gerald W. Smetana; John A. Spertus; Erica W. Swegler
A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Performance Measures (Writing Committee to Develop Performance Measures for Primary Prevention of Cardiovascular Disease) Developed in Collaboration With the American Academy of Family Physicians; American Association of Cardiovascular and Pulmonary Rehabilitation; and Preventive Cardiovascular Nurses Association Endorsed by the American College of Preventive Medicine, American College of Sports Medicine, and Society for Women’s Health Research
Journal of Hypertension | 2011
Guijing Wang; Darwin R. Labarthe
Background To guide resource allocation, policy makers need evidence of the cost-effectiveness of interventions. We summarized such evidence on selected interventions to reduce sodium intake that would be intended as population-wide approaches to control hypertension. Methods We conducted a comprehensive literature review of journal articles published in English from January 2000 to May 2010 by searching the databases of PubMed, EMBASE, MEDLINE, and EconLit. We selected original research articles for abstracting the evidence on cost-effectiveness of interventions, cost savings and the costs of intervention implementation. Results From the 53 references obtained from the literature search, we identified 11 original research articles that provided relevant information on the medical cost savings, implementation costs, or cost-effectiveness of interventions to reduce sodium intake. The interventions were low in cost, e. g., one study showed that the cost ranged from US
Circulation-cardiovascular Quality and Outcomes | 2012
Matthew Tyler Crim; Sung Sug (Sarah) Yoon; Eduardo Ortiz; Hilary K. Wall; Susan E. Schober; Cathleen Gillespie; Paul D. Sorlie; Nora L. Keenan; Darwin R. Labarthe; Yuling Hong
0.03 to 0.32 per person per year for awareness campaign through mass media outlets and government regulations on food products in low and middle-income countries. Population-wide interventions for salt reduction are very cost-effective such as only ARS
Circulation | 2013
Mark D. Huffman; Donald M. Lloyd-Jones; Hongyan Ning; Darwin R. Labarthe; Maria Guzman Castillo; Martin O’Flaherty; Earl S. Ford; Simon Capewell
151 per disability-adjusted life-year (DALY) saved in Argentina, whereas statin therapy to lower high cholesterol was