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Dive into the research topics where David Botstein is active.

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Featured researches published by David Botstein.


Molecular Genetics and Genomics | 1993

A new yeast gene with a myosin-like heptad repeat structure.

Ralf Kölling; Thu Nguyen; Ellson Y. Chen; David Botstein

SummaryWe isolated a gene encoding a 218 kDa myosin-like protein from Saccharomyces cerevisiae using a monoclonal antibody directed against human platelet myosin as a probe. The protein sequence encoded by the MLP1 gene (for myosin-like protein) contains extensive stretches of a heptad-repeat pattern suggesting that the protein can form coiled coils typical of myosins. Immunolocalization experiments using affinity-purified antibodies raised against a TrpE-MLP1 fusion protein showed a dot-like structure adjacent to the nucleus in yeast cells bearing the MLP1 gene on a multicopy plasmid. In mouse epithelial cells the yeast anti-MLP1 antibodies stained the nucleus. Mutants bearing disruptions of the MLP1 gene were viable, but more sensitive to ultraviolet light than wild-type strains, suggesting an involvement of MLP1 in DNA repair. The MLP1 gene was mapped to chromosome 11, 25 cM from met1.


Genes & Development | 1991

A group of interacting yeast DNA replication genes.

Kevin M. Hennessy; Angela Lee; Ellson Y. Chen; David Botstein


Science | 1989

A yeast actin-binding protein is encoded by SAC6, a gene found by suppression of an actin mutation

Alison E M Adams; David Botstein; David G. Drubin


Archive | 1998

Fibroblast growth factor- 19

David Botstein; Audrey Goddard; Austin L. Gurney; Kenneth J. Hillan; David A. Lawrence; Margaret Ann Roy


Archive | 2006

Fibroblast growth factor-19 (FGF-19) nucleic acids and polypeptides and methods of use for the treatment of obesity

David Botstein; Audrey Goddard; Austin L. Gurney; Kenneth J. Hillan; David A. Lawrence; Margaret Ann Roy


Archive | 1996

Tissue plasminogen activator having zymogenic or fibrin specific properties

Stephen Anderson; William F. Bennett; David Botstein; Deborah L. Higgins; Nicholas F. Paoni; Mark J. Zoller


Archive | 1998

Genes amplified in tumours, antibodies against the proteins coded thereby, and their use in diagnosis and treatment of cancer

David Botstein; Audrey Goddard; Austin L. Gurney; Kenneth J. Hillan; David A. Lawrence; Margaret Ann Roy; William I. Wood


Archive | 2003

Polypeptides sharing sequence identity with a fibroblast growth factor polypeptide and nucleic acids encoding the same

David Botstein; Audrey Goddard; Austin L. Gurney; Kenneth J. Hillan; David A. Lawrence; Margaret Ann Roy


Archive | 2001

Secreted and transmembrane polypeptides and nucliec acids encodiing the same

Avi Ashkenazi; Kevin P. Baker; David Botstein; Luc Desnoyers; Dan L. Eaton; Napoleone Ferrara; Sherman Fong; Hans-Peter Gerber; Mary E. Gerritsen; Audrey Goddard; Paul J. Godowski; J. Grimaldi; Austin L. Gurney; Ivar J. Kljavin; Mary A. Napier; James Pan; Nicholas F. Paoni; Margaret Ann Roy; Timothy A. Stewart; Daniel Tumas; Colin K. Watanabe; P. Williams; William I. Wood; Zemin Zhang


Archive | 1999

Secreted amd transmembrane polypeptides and nucleic acids encoding the same

Kevin P. Baker; David Botstein; Dan L. Eaton; Napoleone Ferrara; Ellen Filvaroff; Mary E. Gerritsen; Audrey Goddard; Paul J. Godowski; Christopher J. Grimaldi; Austin L. Gurney; Kenneth J. Hillan; Ivar J. Kljavin; Mary A. Napier; Margaret Ann Roy; Daniel Tumas; William I. Wood

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David A. Lawrence

University of Texas Southwestern Medical Center

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