Margaret Ann Roy
Genentech
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Publication
Featured researches published by Margaret Ann Roy.
Nature | 1998
Robert M. Pitti; Scot A. Marsters; David A. Lawrence; Margaret Ann Roy; Frank C. Kischkel; Patrick Dowd; Arthur Huang; Christopher J. Donahue; Steven Sherwood; Daryl T. Baldwin; Paul J. Godowski; William I. Wood; Austin L. Gurney; Kenneth J. Hillan; Robert L. Cohen; Audrey Goddard; David Botstein; Avi Ashkenazi
Fas ligand (FasL) is produced by activated T cells and natural killer cells and it induces apoptosis (programmed cell death) in target cells through the death receptor Fas/Apo1/CD95 (ref. 1). One important role of FasL and Fas is to mediate immune-cytotoxic killing of cells that are potentially harmful to the organism, such as virus-infected or tumour cells. Here we report the discovery of a soluble decoy receptor, termed decoy receptor 3 (DcR3), that binds to FasL and inhibits FasL-induced apoptosis. The DcR3 gene was amplified in about half of 35 primary lung and colon tumours studied, and DcR3 messenger RNA was expressed in malignant tissue. Thus, certain tumours may escape FasL-dependent immune-cytotoxic attack by expressing a decoy receptor that blocks FasL.
Proceedings of the National Academy of Sciences of the United States of America | 1998
Diane Pennica; Todd A. Swanson; James W. Welsh; Margaret Ann Roy; David A. Lawrence; James Lee; Jennifer Brush; Lisa Taneyhill; Bethanne Deuel; Michael Lew; Colin K. Watanabe; Robert L. Cohen; Mona F. Melhem; Gene G. Finley; Phil Quirke; Audrey Goddard; Kenneth J. Hillan; Austin L. Gurney; David Botstein; Arnold J. Levine
Archive | 2000
Avi Ashkenazi; Audrey Goddard; Paul J. Godowski; Austin L. Gurney; Kenneth J. Hillan; Scot A. Marsters; James Pan; Robert M. Pitti; Margaret Ann Roy; Victoria Smith; Donna M. Stone; Colin K. Watanabe; William I. Wood
Archive | 1998
David Botstein; Audrey Goddard; Austin L. Gurney; Kenneth J. Hillan; David A. Lawrence; Margaret Ann Roy
Archive | 2006
David Botstein; Audrey Goddard; Austin L. Gurney; Kenneth J. Hillan; David A. Lawrence; Margaret Ann Roy
Archive | 1998
Avi Ashkenazi; David Belmont Botstein; Kelly H. Dodge; Audrey San Francisco Goddard; Austin L. Gurney; Kyung Jin Kim; David A. Lawrence; Robert El Cerrito Pitti; Margaret Ann Roy; Daniel Tumas; William I. Wood
Biologicals | 1999
Liming Shi; Jeniffer Ho; Lenore A. Norling; Margaret Ann Roy; Yuan Xu
Archive | 1998
David Botstein; Audrey Goddard; Austin L. Gurney; Kenneth J. Hillan; David A. Lawrence; Margaret Ann Roy; William I. Wood
Archive | 2003
David Botstein; Audrey Goddard; Austin L. Gurney; Kenneth J. Hillan; David A. Lawrence; Margaret Ann Roy
Archive | 2001
Avi Ashkenazi; Kevin P. Baker; David Botstein; Luc Desnoyers; Dan L. Eaton; Napoleone Ferrara; Sherman Fong; Hans-Peter Gerber; Mary E. Gerritsen; Audrey Goddard; Paul J. Godowski; J. Grimaldi; Austin L. Gurney; Ivar J. Kljavin; Mary A. Napier; James Pan; Nicholas F. Paoni; Margaret Ann Roy; Timothy A. Stewart; Daniel Tumas; Colin K. Watanabe; P. Williams; William I. Wood; Zemin Zhang
Collaboration
Dive into the Margaret Ann Roy's collaboration.
