David E. Dines

Pulmonary Lymphangiomyomatosis: With Particular Reference to Steroid-Receptor Assay Studies and Pathologic Correlation

The symptoms of progressive dyspnea, hemoptysis, spontaneous pneumothorax, chylous effusions, and cough in conjunction with ventilatory obstruction and abnormal gas exchange in a young woman should prompt the diagnosis of pulmonary lymphangiomyomatosis. Cytosol steroid-receptor assays and postmortem studies were conducted in an extensive investigation of a case of this disease. A biopsy specimen of the lung disclosed evidence of nuclear translocation of [3H]progesterone and the presence of a cytosolic receptor for progesterone, an indication that this disease could be treated effectively with progestin.

Spontaneous Pneumothorax in Emphysema.

Excerpt Emphysema has been reported to be the cause of pneumothorax in 10% of a large series of patients presenting with spontaneous pneumothorax. Certain pulmonary parenchymal conditions with hone...