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David G. Barrett

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Featured researches published by David G. Barrett.

Journal of Medicinal Chemistry | 2002

Synthesis and evaluation of potent and selective β3 adrenergic receptor agonists containing acylsulfonamide, sulfonylsulfonamide, and sulfonylurea carboxylic acid isosteres

David E. Uehling; Kelly Horne Donaldson; David N. Deaton; Clifton E. Hyman; Elizabeth E. Sugg; David G. Barrett; Robert G. Hughes; Barbara E. Reitter; Kim K. Adkison; Mary E. Lancaster; Frank Lee; Robert Hart; Mark A. Paulik; Bryan W. Sherman; Timothy A. True; Conrad Cowan

Archives of Biochemistry and Biophysics | 2002

Expression, preparation, and high-throughput screening of caspase-8: discovery of redox-based and steroid diacid inhibition.

Gary K. Smith; David G. Barrett; Kevin Blackburn; Michael Cory; Walter S. Dallas; Roderick G. Davis; Daniel F. Hassler; Randy T. McConnell; Mary Moyer; Kurt Weaver

Bioorganic & Medicinal Chemistry Letters | 2005

P2-P3 conformationally constrained ketoamide-based inhibitors of cathepsin K.

David G. Barrett; Virginia M. Boncek; John G. Catalano; David N. Deaton; Anne M. Hassell; Cynthia Holder Jurgensen; Stacey T. Long; Robert B. McFadyen; Aaron B. Miller; Larry R. Miller; J. Alan Payne; John A. Ray; Vicente Samano; Lisa M. Shewchuk; Francis X. Tavares; Kevin J. Wells-Knecht; Derril H. Willard; Lois L. Wright; Hui-Qiang Q. Zhou

Bioorganic & Medicinal Chemistry Letters | 2004

Potent and selective P2-P3 ketoamide inhibitors of cathepsin K with good pharmacokinetic properties via favorable P1', P1, and/or P3 substitutions.

David G. Barrett; John G. Catalano; David N. Deaton; Anne M. Hassell; Stacey T. Long; Aaron B. Miller; Larry R. Miller; Lisa M. Shewchuk; Kevin J. Wells-Knecht; Derril H. Willard; Lois L. Wright

Journal of Organic Chemistry | 1998

DEGRADATIVE REARRANGEMENTS OF N-(T-BUTYLOXYCARBONYL)-O-METHANESULFONYL-HYDROXAMIC ACIDS : A NOVEL, REAGENT-BASED ALTERNATIVE TO THE LOSSEN REARRANGEME NT

Jeffrey A. Stafford; Stephen S. Gonzales; David G. Barrett; Edward Martin Suh; Paul L. Feldman

Bioorganic & Medicinal Chemistry Letters | 2005

Acyclic cyanamide-based inhibitors of cathepsin K.

David G. Barrett; David N. Deaton; Anne M. Hassell; Robert B. McFadyen; Aaron B. Miller; Larry R. Miller; J. Alan Payne; Lisa M. Shewchuk; Derril H. Willard; Lois L. Wright

Bioorganic & Medicinal Chemistry Letters | 2006

Novel, potent P2-P3 pyrrolidine derivatives of ketoamide-based cathepsin K inhibitors.

David G. Barrett; John G. Catalano; David N. Deaton; Anne M. Hassell; Stacey T. Long; Aaron B. Miller; Larry R. Miller; John A. Ray; Vicente Samano; Lisa M. Shewchuk; Kevin J. Wells-Knecht; Derril H. Willard; Lois L. Wright

Bioorganic & Medicinal Chemistry Letters | 2004

Orally bioavailable small molecule ketoamide-based inhibitors of cathepsin K.

David G. Barrett; John G. Catalano; David N. Deaton; Stacey T. Long; Larry R. Miller; Francis X. Tavares; Kevin J. Wells-Knecht; Lois L. Wright; Hui-Qiang Q. Zhou

Bioorganic & Medicinal Chemistry Letters | 2006

Semicarbazone-based inhibitors of cathepsin K, are they prodrugs for aldehyde inhibitors?

Kim K. Adkison; David G. Barrett; David N. Deaton; Robert T. Gampe; Anne M. Hassell; Stacey T. Long; Robert B. McFadyen; Aaron B. Miller; Larry R. Miller; J. Alan Payne; Lisa M. Shewchuk; Kevin J. Wells-Knecht; Derril H. Willard; Lois L. Wright

Archive | 2002

Alpha-ketoamide derivatives as cathepsin k inhibitors

David G. Barrett; David N. Deaton; Robert B. McFadyen; Aaron B. Miller; John A. Ray; Francis X. Tavares; Huiqiang Zhou

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David N. Deaton

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Aaron B. Miller

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Larry R. Miller

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Lois L. Wright

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John G. Catalano

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Kevin J. Wells-Knecht

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Stacey T. Long

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Robert B. McFadyen

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Anne M. Hassell

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Derril H. Willard

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