David L. Benninghoff

Association of thyroid carcinoma with Gardner's syndrome in siblings.

WE are documenting the records of two sisters with Gardners syndrome each of whom also had thyroid carcinoma. In view of the familial setting of their major illness, Gardners syndrome, and its us...

Roentgen anatomy of the ilio-pelvic-aortic lymphatic system.

Lymphography allows complete and systematic anatomical study of the ilio-pelvic-aortic lymphatic system in the living patient. The entire network of lymphatic channels and nodes is shown in its continuity and interrelationships. The first echelon of lymphatic drainage of all the pelvic organs is demonstrated by this procedure. In the past thirty years anatomical studies of the ilio-pelvic lymphatic system have been outnumbered by surgical and pathological investigations using surgical landmarks and specific disease entities. Nodal groups have been named according to their presumed importance. This tendency has not only led to a total confusion in terminology, but also to a distortion of the understanding of the basic anatomy. The object of this study is to show the consistency and completeness of the lymphatic anatomy as demonstrated in lymphograms. Patient Material One hundred and fifty patients were studied by our group. All were adult; the majority were females. In most instances lymphography was done ...

Metastases to palm, sole, nailbed, nose, face and scalp from unsuspected carcinoma of the lung.

A case is recorded in which bizarre metastases to the palm, sole, nailbed, nose, cheek and scalp were the first presenting signs of an unsuspected pulmonary carcinoma. Their unique appearance suggests that a precise phenomenon may be at work, the pathogenesis of which is still unknown. It has not been determined whether they are characteristic of a particular type of primary neoplasm. In the presence of unexplained skin malignancies, the possibility that they may be metastatic should be considered and a search for internal malignancy should be instituted.

Surgical techniques for long-term study of thoracic duct lymph circulation in dogs☆

Abstract Two new surgical techniques for cannulation of the thoracic duct in dogs are presented. Both allow the study of the thoracic duct circulation under physiological conditions in awake and unrestrained animals.

Clinicopathologic correlation of lymphography and lymph node metastases in gynecological neoplasms

A correlation of lymphography with histology was determined in 28 patients with gynecological tumors. Lymphography was of limited value in detecting early metastases but was a reliable indicator when extensive lymphatic involvement was present.

Thoracic duct lymph and lymphocyte studies in man using a thoracic duct “side‐fistula”

A technique for cannulation of the cervical thoracic duct in man is described. It leaves the thoracic duct circulation unimpaired and allows repetitive lymph sampling without loss. This technique can be used to study the re‐circulating pool of long‐lived lymphocytes and thereby help to evaluate better the immunologic status of cancer patients. The technique of side‐cannulation has been used in one patient. Thoracic duct lymphocytes labelled with 51Cr were reinfused IV and were recovered in the thoracic duct in a stable number over a 5‐day study, thereby demonstrating a recirculating lymphocyte pool in man and the applicability of the side‐cannulation to its study.

ANATOMY OF THE FEMALE PELVIC AND AORTIC LYMPHATIC SYSTEMS DEMONSTRATED BY LYMPHANGIOGRAPHY.

Abstract 1. The classical anatomical description of the iliopelvic-aortic lymphatic system has been reviewed. 2. The roentgenographic anatomy of this lymphatic system is clearly demonstrated on lymphangiography and the importance of oblique views is emphasized. 3. The lymphatic drainage of the female pelvic organs is reviewed. 4. The classical descriptions of the pelvic surgeons are briefly reviewed and several differences in terminology clarified.

Radiation Effect on the Barrier Function of the Lymph Node An Experimental Study

There is definite evidence both that the lymph node is an effective lymph filter (4, 12) and that its lymphatic tissues are rapidly depleted following irradiation (2, 3, 9). It is of obvious interest to evaluate the effect of radiation on the barrier function of the lymph node. Clinical radiation therapy often encompasses regional lymph nodes in order to eradicate a neoplastic process. Theoretically it would be disadvantageous if, following such treatment, the barrier function of the lymph node were greatly compromised. In our experiments we studied the filtering efficiency of irradiated popliteal lymph nodes of the dog. The evaluation was based on microradiographs of midplane sections of the lymph node which had been challenged, before removal, by subcutaneous administration of Thorotrast. The quantity and the distribution of the Thorotrast particles provided information concerning the barrier function of these nodes. Review Of Literature In 18, 58 Virchow (11) stated that, in the lymph node, “the elemen...

Visceral Lymphography: An Experimental Study!

During the past decade a vast amount of experience has accumulated in lymphography of the lymph channels and nodes arising in the extremities. This report is a radiologic study of the lymphatic structures originating from the abdominal viscera in dogs. To our knowledge it is the first systematic attempt at visceral lymphography in living animals, although occasional injections of radiopaque or radioactive materials have been made into visceral lymphatics to visualize a small segment (2, 3). The definitive anatomic description of the visceral lymphatic structures of the dog was given by Baum (1). Materials “Acute” experiments were performed in 26 apparently normal mongrel dogs. In 4 animals employed in “chronic” experiments, the side-effects of visceral lymphography were evaluated. Methods Under Pentothal anesthesia and endotracheal intubation, laparotomy was performed. To identify the lymphatics of the viscera, a small amount (0.2 cc) of 4 per cent Direct Sky Blue was injected, usually subserosally. In th...

Technic of chronic thoracic duct “side fistula” for immunologic evaluation of patients with cancer

A technic suitable for long-term study of the human thoracic duct circulation under physiological conditions is described. The results and observations obtained in ten patients studied for three to twenty-one days are presented.