Dayane Pessoa de Araújo

The contributions of antioxidant activity of lipoic acid in reducing neurogenerative progression of Parkinson's disease: a review.

ABSTRACT This work reviews the evidence of the mechanism of neuronal degeneration in Parkinsons disease (PD) and the neuroprotective effect of lipoic acid and its use in the treatment of PD. PD is characterized by slow and progressive degeneration of dopaminergic neurons of the substantia nigra pars compacta, leading to reduction of the striatal dopaminergic terminals. It is known that several factors influence neuronal damage. Among these factors, oxidative stress, immune system activity, microglial cells, and apoptotic mechanisms are of major importance. Currently, several antioxidants have been studied with the aim of reducing/slowing the progression of neurodegenerative processes. Lipoic acid is considered a universal antioxidant because it is an amphipathic substance. Lipoic acid and its reduced form, dihidrolipoic acid, act against reactive oxygen species, reducing oxidative stress. Therefore, this antioxidant has been used in the treatment of many diseases, including a new perspective for the treatment of Parkinsons disease.

Behavioral and Neurochemical Effects of Alpha-Lipoic Acid in the Model of Parkinson’s Disease Induced by Unilateral Stereotaxic Injection of 6-Ohda in Rat

This study aimed to investigate behavioral and neurochemical effects of α-lipoic acid (100 mg/kg or 200 mg/kg) alone or associated with L-DOPA using an animal model of Parkinsons disease induced by stereotaxic injection of 6-hydroxydopamine (6-OHDA) in rat striatum. Motor behavior was assessed by monitoring body rotations induced by apomorphine, open field test and cylinder test. Oxidative stress was accessed by determination of lipid peroxidation using the TBARS method, concentration of nitrite and evaluation of catalase activity. α-Lipoic acid decreased body rotations induced by apomorphine, as well as caused an improvement in motor performance by increasing locomotor activity in the open field test and use of contralateral paw (in the opposite side of the lesion produced by 6-OHDA) at cylinder test. α-lipoic acid showed antioxidant effects, decreasing lipid peroxidation and nitrite levels and interacting with antioxidant system by decreasing of endogenous catalase activity. Therefore, α-lipoic acid prevented the damage induced by 6-OHDA or by chronic use of L-DOPA in dopaminergic neurons, suggesting that α-lipoic could be a new therapeutic target for Parkinsons disease prevention and treatment.

Central effects of lipoic acid associated with paroxetine in mice.

Antidepressants, including selective serotonin reuptake inhibitors, are commonly prescribed for the treatment of affective disorders such as anxiety and depression. The purpose of this study was to investigate the central effects of acute administration of paroxetine (PXT) combined with lipoic acid (LA) on various behavioral models in mice. Paroxetine (10 and 20 mg/kg), LA (100 mg/kg), or vehicle was administered, intraperitoneally, 30 minutes before the tests. The results showed that PXT (10 mg/kg) alone and in combination with LA increased locomotor activity. In the anxiety models studied, an anxiolytic effect was observed after the administration of LA and PXT. In the tail suspension test, PXT at both doses and in combination with LA caused a significant decrease in immobility time. These results indicate possible anxiolytic and antidepressant effects of LA associated with PXT. These data suggest that coadministration of LA and PXT may improve anxiolytic and antidepressant responses, and being more effective than each drug alone. However, further studies are necessary to investigate the mechanism by which antioxidants exert antidepressant or anxiolytic action.

Plumeran alkaloids and glycosides from the seeds of aspidosperma pyrifolium mart.

The residual aqueous fraction of the liquid-liquid partition of the ethanol extract from seeds of Aspidosperma pyrifolium showed antinociceptive and anti-inflammatory activities in the formalin test, abdominal writhing induced by acetic acid, and paw edema induced by carrageenan. Its phytochemical analysis led to the isolation of a new alkaloid with a rearranged plumeran skeleton, the (-)-(3S,7S,21R)-rel-(3αH)-15(14→3)-abeo-2,16,17,20,6,7-hexahydro-15H,8aH,16a,20a-ethano-1H-indolizino[3,1-cd]carbazole, in addition to six other known plumeran alkaloids, one tetrahydro-β-carboline alkaloid, and the glycosides of two iridoids and of salycilic acid, that are being reported for the first time for A. pyrifolium. One of the known alkaloids is being reported for the first time from a natural source. The nuclear magnetic resonance (NMR) data, and the correspondent assignments, of some alkaloids already reported in the literature are suggested to be revised. Structures of all compounds were characterized by 1D and 2D NMR and Fourier transform infrared (FT-IR) spectroscopies and high-resolution electrospray ionization mass spectrometry (HRESIMS), and comparison with data from literature.

The Treadmill Exercise Protects against Dopaminergic Neuron Loss and Brain Oxidative Stress in Parkinsonian Rats

Parkinsons disease (PD), a progressive neurological pathology, presents motor and nonmotor impairments. The objectives were to support data on exercise benefits to PD. Male Wistar rats were distributed into sham-operated (SO) and 6-OHDA-lesioned, both groups without and with exercise. The animals were subjected to treadmill exercises (14 days), 24 h after the stereotaxic surgery and striatal 6-OHDA injection. Those from no-exercise groups stayed on the treadmill for the same period and, afterwards, were subjected to behavioral tests and euthanized for neurochemical and immunohistochemical assays. The data, analyzed by ANOVA and Tukey post hoc test, were considered significant for p < 0.05. The results showed behavioral change improvements in the 6-OHDA group, after the treadmill exercise, evaluated by apomorphine rotational behavior, open field, and rota rod tests. The exercise reduced striatal dopaminergic neuronal loss and decreased the oxidative stress. In addition, significant increases in BDNF contents and in immunoreactive cells to TH and DAT were also observed, in striata of the 6-OHDA group with exercise, relatively to those with no exercise. We conclude that exercise improves behavior and dopaminergic neurotransmission in 6-OHDA-lesioned animals. The increased oxidative stress and decreased BDNF contents were also reversed, emphasizing the importance of exercise for the PD management.

Nursing and head injury: literature systematic review study

ABSTRACT Objective : to analyze the scientific research about the nursing care for Traumatic Brain Injury – TBI, with the perspective of the advent of the improvements in upon the guide of strategic canes in the hospital. Methodology : this is about a descriptive study of systematic review a literature it was performed as a search in the information platform databases LILACS, BDENF and MEDLINE, for descriptors Nursing Brain Injuries and Craniocerebral Trauma. To refine the search was conducted the intersection of keywords in English, Spanish and Portuguese. The inclusion criteria for articles were that they were published in national and international independent of which the journal during the period January 2000 to January 2010 and available in English, Spanish or Portuguese. Results : there were nineteen articles five in Spanish, seven in English and seven in Portuguese. The biggest majority of work was restrict the collected facts characterize the quantity of victims from TBI and the efficiency of the strategic cares that was considered as a more efficient recovery in the hospital. Conclusions : The small number of published articles express the nursing shortage has knowledge in neurology. Moreover, it’s necessary check the chosen way to the neurological nursing. That’s not frequent and has given wrong information about the clinical practice inside of the hospital rather than a comprehensive health care . Descriptors : nursing; brain injuries; craniocerebral trauma. RESUMO Objetivo : analisar a producao cientifica sobre a assistencia de Enfermagem as vitimas de Traumatismo Cranioencefalico - TCE, tendo como perspectiva o advento de melhorias no tocante a planificacao de estrategias de cuidado em âmbito hospitalar. Metodologia : trata-se de um estudo descritivo, do tipo revisao sistematica da literatura. Foi realizada uma busca nas bases de dados LILACS, BDENF e MEDLINE, pelos descritores Enfermagem, Traumatismos Encefalicos e Traumatismos Craniocerebrais. Para refinamento da busca, foi realizado o cruzamento dos unitermos nos idiomas ingles, espanhol e portugues. Os criterios de inclusao dos artigos eram que os mesmos estivessem publicados em periodicos nacionais e internacionais independente do qualis , durante o periodo de Janeiro de 2000 a Janeiro de 2010 e disponiveis no idioma ingles, espanhol ou portugues. Resultados : foram encontrados 19 artigos, sendo cinco em espanhol, sete em ingles e sete em portugues. A grande maioria dos trabalhos restringe-se a caracterizar a demanda das vitimas de TCE e/ou a validar estrategias de cuidados que vislumbrem uma melhor recuperacao no âmbito hospitalar. Conclusoes : O numero reduzido de trabalhos publicados expressa a carencia que a enfermagem tem de conhecimentos no âmbito da neurologia. Alem disso, e preciso (re)discutir o rumo tomado por essas pesquisas, pois elas tem demonstrado uma supervalorizacao das praticas clinicas intra-hospitalares em detrimento a uma assistencia integral. Descritores: enfermagem; traumatismos encefalicos; traumatismos craniocerebrais. RESUMEN Objetivo : analizar la literatura cientifica sobre los cuidados de enfermeria para la lesion cerebral traumatica - TEC, con la perspectiva de la llegada de mejoras en relacion con la planificacion de estrategias de atencion en el hospital. Metodologia : este estudio es una revision descriptiva y sistematica de la literatura. Se realizo una busqueda en la bases de datos LILACS, BDENF y MEDLINE, los descriptores para la Enfermeria, y Lesiones Cerebrales Craneocerebrales Trauma. Para refinar la busqueda se llevo a cabo el cruce de palabras clave en Ingles, espanol y portugues. Los criterios de inclusion para que los articulos fueron publicados en nacionales e internacionales independientes de la que la revista durante el periodo comprendido desde enero 2000 hasta enero 2010 y disponibles en Ingles, espanol y portugues . Resultados : se encontraron diecinueve articulos, cinco en espanol, siete en Ingles y siete en portugues. La gran mayoria del trabajo se limita a caracterizar la demanda de victimas de TCE y / o validar las estrategias de atencion que contemplen una mejor recuperacion en el hospital. Conclusiones : el pequeno numero de trabajos publicados que expresan la escasez de enfermeras tiene conocimiento de la neurologia. Tambien, es necesario (re)examinar el camino recorrido por la investigacion en enfermeria neurologica. Ademas no son frecuentes, han mostrado una sobreestimacion en el hospital de la practica clinica en vez de una atencion integral de salud. Descriptores : enfermeria; las lesiones cerebrales; traumatismo craneoencefalico.

State of the art in the treatment of mandibular fractures caused by firearms: case report

Injuries to the face represent a significant risk to the health of the individual, mainly because of its significance, both functional, because it houses sensory organs and part of the respiratory and digestive systems, as well as esthetic. In this scenario, gunshot wounds in this location cause great concern on account of the magnitude of the damage, and the Oral and Maxillofacial Surgery and Traumatology team must act so that the treatment enables the rehabilitation of the patient in the shortest possible time, with a minimum of complications and sequelae. The objective of this study is to report a clinical case of a 19-year-old female patient with a comminuted fracture of the mandible body caused by a firearm projectile, treated immediately with stable internal fixation using the 2.00 mm plate-screw system for simplification of the fracture and a 2.4 mm reconstruction locking-plate on the bone gap. Relevant aspects of the surgical technique and tactics are reviewed and long-term follow-up of the patient is presented. Indexing terms: Firearms. Internal fixation of fractures. Mandible. Therapeutics.

Corrigendum to “The Treadmill Exercise Protects against Dopaminergic Neuron Loss and Brain Oxidative Stress in Parkinsonian Rats”

[This corrects the article DOI: 10.1155/2017/2138169.].

Expansion and Phenotypic Changes of Mouse Bone Marrow Mesenchymal Cells Cultured with FGF-2 and Facial Nerve-Conditioned Medium

Eudes Euler de Souza Lucena ; Hécio Henrique Araújo de Morais; Dayane Pessoa de Araújo ; José Rodolfo Lopes de Paiva Cavalcanti; Eduardo Pereira de Azevedo; Dinalva Brito de Queiroz; Marco Antônio Botelho; Amália Cinthia Meneses do Rêgo; Irami Araújo Filho ; Carlos Augusto Galvão Barboza; Expedito Silva do Nascimento Júnior ; Miriam Stela Maris de Oliveira Costa; Jeferson de Sousa Cavalcante 4 & Fausto Pierdoná Guzen

Supplementation with Curcuma longa Reverses Neurotoxic and Behavioral Damage in Models of Alzheimer’s Disease: A Systematic Review

Background: The formation of senile plaques and neurofibrillary tangles of the tau protein are the main pathological mechanism of Alzheimer’s disease (AD). Current therapies for AD offer discrete benefits to the clinical symptoms and do not prevent the continuing degeneration of neuronal cells. Therefore, novel therapeutic strategies have long been investigated, where curcumin (Curcuma longa) has shown some properties that can prevent the deleterious processes involved in neurodegenerative diseases. Objective: The aim of the present work is to review studies that addressed the effects of curcumin in experimental models (in vivo and in vitro) for AD. Method: This study is a systematic review conducted between January and June 2017, in which a consultation of scientific articles from indexed periodicals was carried out in Science Direct, United States National Library of Medicine (PubMed), Cochrane Library and Scielo databases, using the following descriptors: “Curcuma longa”, “Curcumin” and “Alzheimer’s disease”. Results: A total of 32 studies were analyzed, which indicated that curcumin supplementation reverses neurotoxic and behavioral damages in both in vivo and in vitro models of AD. Conclusion: The administration of curcumin in experimental models seems to be a promising approach in AD, even though it is suggested that additional studies must be conducted using distinct doses and through other routes of administration.