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Dayne Fanfair

Bristol-Myers Squibb

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Publication

Featured researches published by Dayne Fanfair.

Journal of Organic Chemistry | 2014

Synthesis of the 6-Azaindole Containing HIV-1 Attachment Inhibitor Pro-Drug, BMS-663068

Ke Chen; Christina Risatti; Michael Bultman; Maxime Soumeillant; Jim Simpson; Bin Zheng; Dayne Fanfair; Michelle Mahoney; Boguslaw Mudryk; Richard J. Fox; Yi Hsaio; Saravanababu Murugesan; David A. Conlon; Frederic G. Buono; Martin D. Eastgate

The development of a short and efficient synthesis of a complex 6-azaindole, BMS-663068, is described. Construction of the 6-azaindole core is quickly accomplished starting from a simple pyrrole, via a regioselective Friedel-Crafts acylation, Pictet-Spengler cyclization, and a radical-mediated aromatization. The synthesis leverages an unusual heterocyclic N-oxide α-bromination to functionalize a critical C-H bond, enabling a highly regioselective copper-mediated Ullmann-Goldberg-Buchwald coupling to install a challenging triazole substituent. This strategy resulted in an efficient 11 step linear synthesis of this complex clinical candidate.

Tetrahedron | 2013

Development of a scalable palladium-catalyzed α-arylation process for the synthesis of a CGRP antagonist

Lopa V. Desai; Michael B. Hay; David K. Leahy; Carolyn S. Wei; Dayne Fanfair; Thorsten Rosner; Yi Hsiao

Organic Process Research & Development | 2014

A Method for Heteroaromatic Nitration Demonstrating Remarkable Thermal Stability

Gregory L. Beutner; Lopa V. Desai; Dayne Fanfair; Paul C. Lobben; Eric Anderson; Simon Leung; Martin D. Eastgate

Archive | 2012

Methods of making HIV attachment inhibitor prodrug compound and intermediates

Jonathan C. Tripp; Dayne Fanfair; Mitchell J. Schultz; Saravanababu Murugesan; Richard J. Fox; Chung-Pin H. Chen; Sabrina E. Ivy; Joseph Payack; Wendel W. Doubleday

Organic Process Research & Development | 2017

Preparation of the HIV Attachment Inhibitor BMS-663068. Part 1. Evolution of Enabling Strategies

Richard J. Fox; Jonathan C. Tripp; Mitchell J. Schultz; Joseph F. Payack; Dayne Fanfair; Boguslaw Mudryk; Saravanababu Murugesan; Chung-Pin H. Chen; Thomas E. La Cruz; Sabrina E. Ivy; Sévrine Broxer; Ryan Cullen; Deniz Erdemir; Peng Geng; Zhongmin Xu; Alan Fritz; Wendel W. Doubleday; David A. Conlon

Archive | 2014

Methods for the preparation of HIV attachment inhibitor piperazine prodrug compound

Martin D. Eastgate; Michael Bultman; Ke Chen; Dayne Fanfair; Richard J. Fox; Thomas E. La Cruz; Boguslaw Mudryk; Christina Risatti; James H. Simpson; Maxime Soumeillant; Jonathan C. Tripp; Yi Xiao

Organic Process Research & Development | 2017

Preparation of the HIV Attachment Inhibitor BMS-663068. Part 5. Selective C-7 Bromination of the 6-Azaindole Core

Francisco González-Bobes; Matthew R. Hickey; Benjamin Cohen; Michael Bultman; Ke Chen; Dayne Fanfair; Victor W. Rosso; Neil A. Strotman; Boguslaw Mudryk; Saravanababu Murugesan; Richard L. Schild; Sabrina E. Ivy; Martin D. Eastgate; Jason T. Sweeney; David A. Conlon

Organic Process Research & Development | 2017

Preparation of the HIV Attachment Inhibitor BMS-663068. Part 7. Development of a Regioselective Ullmann–Goldberg–Buchwald Reaction

William P. Gallagher; Maxime Soumeillant; Ke Chen; Richard J. Fox; Yi Hsiao; Brendan Mack; Vidya Iyer; Junying Fan; Jason Zhu; Gregory L. Beutner; Steven M. Silverman; Dayne Fanfair; Andrew W. Glace; Adam Freitag; Jason T. Sweeney; Yining Ji; Donna G. Blackmond; Martin D. Eastgate; David A. Conlon

Organic Process Research & Development | 2017

Preparation of the HIV Attachment Inhibitor BMS-663068. Part 4. Synthesis of the 6-Azaindole Core

Michael Bultman; Junying Fan; Dayne Fanfair; Michelle Soltani; Jim Simpson; Saravanababu Murugesan; Maxime Soumeillant; Ke Chen; Christina Risatti; Thomas E. La Cruz; Frederic G. Buono; Victor Hung; Richard L. Schild; Sabrina E. Ivy; Jason T. Sweeney; David A. Conlon; Martin D. Eastgate

Organic Process Research & Development | 2017

Preparation of the HIV Attachment Inhibitor BMS-663068. Part 3. Mechanistic Studies Enable a Scale-Independent Friedel–Crafts Acylation

Gregory L. Beutner; Jacob Albrecht; Junying Fan; Dayne Fanfair; Michael Lawler; Michael Bultman; Ke Chen; Sabrina E. Ivy; Richard L. Schild; Jonathan C. Tripp; Saravanababu Murugesan; Konstantinos Dambalas; Douglas D. McLeod; Jason T. Sweeney; Martin D. Eastgate; David A. Conlon

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Collaboration

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Saravanababu Murugesan

Bristol-Myers Squibb

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Martin D. Eastgate

Bristol-Myers Squibb

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Sabrina E. Ivy

Bristol-Myers Squibb

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David A. Conlon

Merck

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Ke Chen

Bristol-Myers Squibb

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Michael Bultman

Bristol-Myers Squibb

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Richard J. Fox

Union College

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Jonathan C. Tripp

Bristol-Myers Squibb

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Boguslaw Mudryk

Bristol-Myers Squibb

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Maxime Soumeillant

Bristol-Myers Squibb

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