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Saravanababu Murugesan

Bristol-Myers Squibb

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Publication

Featured researches published by Saravanababu Murugesan.

Journal of Organic Chemistry | 2014

Synthesis of the 6-Azaindole Containing HIV-1 Attachment Inhibitor Pro-Drug, BMS-663068

Ke Chen; Christina Risatti; Michael Bultman; Maxime Soumeillant; Jim Simpson; Bin Zheng; Dayne Fanfair; Michelle Mahoney; Boguslaw Mudryk; Richard J. Fox; Yi Hsaio; Saravanababu Murugesan; David A. Conlon; Frederic G. Buono; Martin D. Eastgate

The development of a short and efficient synthesis of a complex 6-azaindole, BMS-663068, is described. Construction of the 6-azaindole core is quickly accomplished starting from a simple pyrrole, via a regioselective Friedel-Crafts acylation, Pictet-Spengler cyclization, and a radical-mediated aromatization. The synthesis leverages an unusual heterocyclic N-oxide α-bromination to functionalize a critical C-H bond, enabling a highly regioselective copper-mediated Ullmann-Goldberg-Buchwald coupling to install a challenging triazole substituent. This strategy resulted in an efficient 11 step linear synthesis of this complex clinical candidate.

Organic Process Research & Development | 2012

Development of a Process for the Preparation of Chloromethyl Chlorosulfate

Bin Zheng; Masano Sugiyama; Martin D. Eastgate; Alan Fritz; Saravanababu Murugesan; David A. Conlon

Chemical Engineering in the Pharmaceutical Industry: R&D to Manufacturing | 2010

Design of Filtration and Drying Operations

Saravanababu Murugesan; Praveen K. Sharma; Jose E. Tabora

Archive | 2012

Methods of making HIV attachment inhibitor prodrug compound and intermediates

Jonathan C. Tripp; Dayne Fanfair; Mitchell J. Schultz; Saravanababu Murugesan; Richard J. Fox; Chung-Pin H. Chen; Sabrina E. Ivy; Joseph Payack; Wendel W. Doubleday

Organic Process Research & Development | 2017

Preparation of the HIV Attachment Inhibitor BMS-663068. Part 1. Evolution of Enabling Strategies

Richard J. Fox; Jonathan C. Tripp; Mitchell J. Schultz; Joseph F. Payack; Dayne Fanfair; Boguslaw Mudryk; Saravanababu Murugesan; Chung-Pin H. Chen; Thomas E. La Cruz; Sabrina E. Ivy; Sévrine Broxer; Ryan Cullen; Deniz Erdemir; Peng Geng; Zhongmin Xu; Alan Fritz; Wendel W. Doubleday; David A. Conlon

Organic Process Research & Development | 2017

Preparation of the HIV Attachment Inhibitor BMS-663068. Part 5. Selective C-7 Bromination of the 6-Azaindole Core

Francisco González-Bobes; Matthew R. Hickey; Benjamin Cohen; Michael Bultman; Ke Chen; Dayne Fanfair; Victor W. Rosso; Neil A. Strotman; Boguslaw Mudryk; Saravanababu Murugesan; Richard L. Schild; Sabrina E. Ivy; Martin D. Eastgate; Jason T. Sweeney; David A. Conlon

Organic Process Research & Development | 2012

Lean Filtration: Approaches for the Estimation of Cake Properties

Saravanababu Murugesan; Daniel M. Hallow; James P. Vernille; Jean Tom; Jose E. Tabora

Organic Process Research & Development | 2017

Preparation of the HIV Attachment Inhibitor BMS-663068. Part 6. Friedel–Crafts Acylation/Hydrolysis and Amidation

Bin Zheng; Steven M. Silverman; Sarah Evelyn Steinhardt; Sergei V. Kolotuchin; Vidya Iyer; Junying Fan; Dimitri Skliar; Douglas D. McLeod; Michael Bultman; Jonathan C. Tripp; Saravanababu Murugesan; Thomas E. La Cruz; Jason T. Sweeney; Martin D. Eastgate; David A. Conlon

Organic Process Research & Development | 2017

Preparation of the HIV Attachment Inhibitor BMS-663068. Part 4. Synthesis of the 6-Azaindole Core

Michael Bultman; Junying Fan; Dayne Fanfair; Michelle Soltani; Jim Simpson; Saravanababu Murugesan; Maxime Soumeillant; Ke Chen; Christina Risatti; Thomas E. La Cruz; Frederic G. Buono; Victor Hung; Richard L. Schild; Sabrina E. Ivy; Jason T. Sweeney; David A. Conlon; Martin D. Eastgate

Organic Process Research & Development | 2017

Preparation of the HIV Attachment Inhibitor BMS-663068. Part 3. Mechanistic Studies Enable a Scale-Independent Friedel–Crafts Acylation

Gregory L. Beutner; Jacob Albrecht; Junying Fan; Dayne Fanfair; Michael Lawler; Michael Bultman; Ke Chen; Sabrina E. Ivy; Richard L. Schild; Jonathan C. Tripp; Saravanababu Murugesan; Konstantinos Dambalas; Douglas D. McLeod; Jason T. Sweeney; Martin D. Eastgate; David A. Conlon

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Collaboration

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Dayne Fanfair

Bristol-Myers Squibb

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David A. Conlon

Merck

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Sabrina E. Ivy

Bristol-Myers Squibb

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Martin D. Eastgate

Bristol-Myers Squibb

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Michael Bultman

Bristol-Myers Squibb

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Jonathan C. Tripp

Bristol-Myers Squibb

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Ke Chen

Bristol-Myers Squibb

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Richard J. Fox

Union College

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Richard L. Schild

Bristol-Myers Squibb

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Thomas E. La Cruz

Bristol-Myers Squibb

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