Deddi Prima Putra

The Alkaloids ofOphiorrhiza filistipula

Extraction of the fresh leaves of Ophiorrhiza filistipula ( Rubiaceae ) has yielded the alkaloids normalindine (2), 7-methoxycamptothecin (6) and strictosidinic acid (II). The configurations of the Strychnos alkaloids dolichantoside and isodolichantoside are revised.

The Alkaloids of Ophiorrhiza cf. ferruginea

Extraction of the aerial parts of Ophiorrhiza cf. ferruginea ( Rubiaceae ) has yielded the tertiary indole alkaloids dihydrocycloakagerine (1), 3,14-dihydrodecussine (mostuenine) (3) and tetrahydroakagerine (4), and the quaternary indole alkaloid isomalindine (5). The structures of dihydrocycloakagerine (1) and isomalindine (5) are confirmed by the X-ray method.

Indole Alkaloids from Two Species of Ophiorrhiza

Extraction of the aerial parts of Ophiorrhiza rosacea Ridley (Rubiaceae) has yielded harman-2-oxide (1). Extraction of the aerial parts of O. kunstleri King yielded the alkaloids palicoside (3) and 3,14-didehydro-19- methylnormalindine (8). The structures of these compounds followed from their spectroscopic properties.

Ophiorrhizine, a new quaternary indole alkaloid related to cinchonamine, from Ophiorrhiza major Ridl.

Extraction of the aerial parts of Ophiorrhiza major Ridl. has yielded a new C19 pentacyclic quaternary indole alkaloid, ophiorrhizine. The structure was established as 1 on the grounds of its spectral properties (optical rotation) and its X-ray molecular structure. Its biosynthetic relationship to the Cinchona alkaloids is discussed.

Labdane diterpene lactones of Vitex pubescens and their antileukemic properties

Vitex pubescens belonging to the Verbenaceae family, has been historically used as a folk medicine in Indonesia. The dichloromethane extract of V. pubescens stembarks interfered cell proliferation and induced apoptosis in human leukemia HL-60 cells. Our phytochemical investigation resulted in the isolation of several constituents and their chemical structures were determined by spectroscopic analyses. Upon treatment with labdane diterpene lactones, relatively high inhibition of cell proliferation and apoptotic response of the cells were observed. Furthermore, the structure-activity relationship analysis with clerodane diterpenes revealed that a γ-butyrolactone ring contributes their antileukemic potency. Overall, these findings enhanced the ethnopharmacological relevance of V. pubescens for cancer chemotherapy.