Deirdre M. King

Development of a vessel-mimicking material for use in anatomically realistic Doppler flow phantoms

Polyvinyl alcohol cryogel (PVA-C) is presented as a vessel-mimicking material for use in anatomically realistic Doppler flow phantoms. Three different batches of 10% wt PVA-C containing (i) PVA-C alone, (ii) PVA-C with antibacterial agent and (iii) PVA-C with silicon carbide particles were produced, each with 1-6 freeze-thaw cycles. The resulting PVA-C samples were characterized acoustically (over a range 2.65 to 10.5 MHz) and mechanically to determine the optimum mixture and preparation for mimicking the properties of healthy and diseased arteries found in vivo. This optimum mix was reached with the PVA-C with antibacterial agent sample, prepared after two freeze/thaw cycles, which achieved a speed of sound of 1538 ± 5 m s(-1) and a Youngs elastic modulus of 79 ± 11 kPa. This material was used to make a range of anatomically realistic flow phantoms with varying degrees of stenoses, and subsequent flow experiments revealed that higher degrees of stenoses and higher velocities could be achieved without phantom rupturing compared with a phantom containing conventional wall-less vessels.

Development of a Range of Anatomically Realistic Renal Artery Flow Phantoms

Computer-aided modelling techniques were used to generate a range of anatomically realistic phantoms of the renal artery from medical images of a 64-slice CT data set acquired from a healthy volunteer. From these data, models of a normal healthy renal artery and diseased renal arteries with 30%, 50%, 70% and 85% stenoses were generated. Investment casting techniques and a low melting point alloy were used to create the vessels with varying degrees of stenosis. The use of novel inserts significantly reduced the time, materials and cost required in the fabrication of these anatomically realistic phantoms. To prevent residual metal remaining in the final phantom lumens a technique employing clingfilm was used to remove all molten metal from the lumen. These novel flow phantoms developed using efficient methods for producing vessels with various degrees of stenosis can provide a means of evaluation of current and emerging ultrasound technology.

Comparative imaging study in ultrasound, MRI, CT, and DSA using a multimodality renal artery phantom

PURPOSE A range of anatomically realistic multimodality renal artery phantoms consisting of vessels with varying degrees of stenosis was developed and evaluated using four imaging techniques currently used to detect renal artery stenosis (RAS). The spatial resolution required to visualize vascular geometry and the velocity detection performance required to adequately characterize blood flow in patients suffering from RAS are currently ill-defined, with the result that no one imaging modality has emerged as a gold standard technique for screening for this disease. METHODS The phantoms, which contained a range of stenosis values (0%, 30%, 50%, 70%, and 85%), were designed for use with ultrasound, magnetic resonance imaging, x-ray computed tomography, and x-ray digital subtraction angiography. The construction materials used were optimized with respect to their ultrasonic speed of sound and attenuation coefficient, MR relaxometry (T1, T2) properties, and Hounsfield number/x-ray attenuation coefficient, with a design capable of tolerating high-pressure pulsatile flow. Fiducial targets, incorporated into the phantoms to allow for registration of images among modalities, were chosen to minimize geometric distortions. RESULTS High quality distortion-free images of the phantoms with good contrast between vessel lumen, fiducial markers, and background tissue to visualize all stenoses were obtained with each modality. Quantitative assessments of the grade of stenosis revealed significant discrepancies between modalities, with each underestimating the stenosis severity for the higher-stenosed phantoms (70% and 85%) by up to 14%, with the greatest discrepancy attributable to DSA. CONCLUSIONS The design and construction of a range of anatomically realistic renal artery phantoms containing varying degrees of stenosis is described. Images obtained using the main four diagnostic techniques used to detect RAS were free from artifacts and exhibited adequate contrast to allow for quantitative measurements of the degree of stenosis in each phantom. Such multimodality phantoms may prove useful in evaluating current and emerging US, MRI, CT, and DSA technology.

A review of the recommendations governing quality assurance of ultrasound systems used for guidance in prostate brachytherapy

Ultrasound guided brachytherapy for the treatment of prostate cancer has become a routine treatment option, due to many benefits including patient recovery and dose localisation [1]; however it is not clear whether the standards which govern the image quality for these systems are adequate. Upon review of the recommended standards for ultrasound systems used in prostate brachytherapy procedures, the recommended tests do not appear to be specific to the clinical application of ultrasound guided prostate brachytherapy. Rather they are generic and similar to those recommended for other clinical applications such as general abdominal scanning [2]. Furthermore, there is growing evidence that these tests should be specific to the clinical application [3,4] in order to gain meaningful data about the performance of the system for the application, and also to detect clinically relevant changes in quality control results. An additional problem is that there are no clinically relevant test phantom recommended for the quality assurance of ultrasound systems used in prostate brachytherapy. The image quality for this application of ultrasound needs to be monitored to ensure consistent levels of confidence in the procedure. This paper reviews the currently recommended test guidelines and test phantoms for ultrasound systems used in prostate brachytherapy from the different standard bodies and professional organisations. A critical analysis of those tests which are most reflective of the imaging and guidance tasks undertaken in an ultrasound guided prostate brachytherapy procedure will also be presented to inform the design of a TRUS quality assurance protocol.

P6B-11 How Fat Layers Affect the Clinical Diagnosis from Doppler Data

Ultrasound Doppler data are routinely used in the clinical diagnosis of degree of stenosis in the renal artery. In this study the effect of fat layers on maximum velocity estimations was determined using both a Doppler string and flow phantom. Using an ATL HDI 3000 with two broadband transducers (C4-2 and L12-5), the maximum velocity was estimated for a range of velocities with and without the presence of a fat layer. The results indicate that the introduction of a fat layer has a significant effect on the overestimation of the maximum velocity when the string phantom is used. However, in the case of the flow phantom which is more physiologically representative of in vivo conditions, underestimation of the maximum velocity was observed; this may cause patients to be diagnosed as having a smaller stenosis than is actually present.