Denis Labrecque | Researchain

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Featured researches published by Denis Labrecque.

Bioorganic & Medicinal Chemistry Letters | 2004

Discovery of thiophene-2-carboxylic acids as potent inhibitors of HCV NS5B polymerase and HCV subgenomic RNA replication. Part 1: Sulfonamides

Laval Chan; Sanjoy K. Das; T. Jagadeeswar Reddy; Carl Poisson; Melanie Proulx; Oswy Z. Pereira; Marc Courchesne; Caroline Roy; Wuyi Wang; Arshad Siddiqui; Constantin G. Yannopoulos; Nghe Nguyen-Ba; Denis Labrecque; Richard Bethell; Martine Hamel; Philippe Courtemanche-Asselin; Lucille L'Heureux; Maud David; Olivier Nicolas; Stéphanie Brunette; Darius Bilimoria; Jean Bedard

The discovery of a novel class of HCV NS5B polymerase inhibitors, 3-arylsulfonylamino-5-phenyl-thiophene-2-carboxylic acids is described. SAR studies have yielded several potent inhibitors of HCV polymerase as well as of HCV subgenomic RNA replication in Huh-7 cells.

Tetrahedron Letters | 2001

Enantioselective total synthesis of salicylihalamides A and B

Denis Labrecque; Sylvie Charron; Rabindra Rej; Charles Blais; Serge Lamothe

Abstract We have devised a total synthesis of (12 R ,13 S ,15 R ) salicylihalamides A and B, which allowed revision of the absolute stereochemistry of the natural compounds. The same strategy was then applied to the preparation of naturally occurring salicylihalamides.

Bioorganic & Medicinal Chemistry Letters | 2005

Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. 2. Structure-activity relationships of the 7- and 5-, 6-, 8-positions.

William Kemnitzer; Shailaja Kasibhatla; Songchun Jiang; Hong Zhang; Jianghong Zhao; Shaojuan Jia; Lifen Xu; Candace Crogan-Grundy; Real Denis; Nancy Barriault; Louis Vaillancourt; Sylvie Charron; Jennifer Dodd; Giorgio Attardo; Denis Labrecque; Serge Lamothe; Henriette Gourdeau; Ben Tseng; John Drewe; Sui Xiong Cai

Molecular Cancer Therapeutics | 2004

Antivascular and antitumor evaluation of 2-amino-4-(3-bromo-4,5-dimethoxy-phenyl)-3-cyano-4H-chromenes, a novel series of anticancer agents

Henriette Gourdeau; Lorraine Leblond; Bettina Hamelin; Clemence Desputeau; Kelly Dong; Irenej Kianicka; Dominique Custeau; Chantal Boudreau; Lilianne Geerts; Sui-Xiong Cai; John Drewe; Denis Labrecque; Shailaja Kasibhatla; Ben Tseng

Bioorganic & Medicinal Chemistry Letters | 2008

Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based HTS assay. Part 5: Modifications of the 2- and 3-positions

William Kemnitzer; Songchun Jiang; Yan Wang; Shailaja Kasibhatla; Candace Crogan-Grundy; Monica Bubenik; Denis Labrecque; Real Denis; Serge Lamothe; Giorgio Attardo; Henriette Gourdeau; Ben Tseng; John Drewe; Sui Xiong Cai

Official Gazette of the United States Patent and Trademark Office Patents | 2000

Thiophene integrin inhibitors

Denis Labrecque; Giorgio Attardo; Monica Bubenik; Laval Chan; Sylvie Charron; Real Denis; Guy Falardeau; Serge Lamothe; Patrice Préville; Boulos Zacharie

Archive | 1999