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Featured researches published by Denise Oliveira.


Arquivos Brasileiros De Cardiologia | 2012

Hidratação com bicarbonato de sódio não previne a nefropatia de contraste: ensaio clínico multicêntrico

Vitor Gomes; Ricardo Lasevitch; Valter Correia de Lima; Fábio Sândoli de Brito; Juan Carlos Perez-Alva; Bruno Moulin; Airton Arruda; Denise Oliveira; Paulo Ricardo Avancini Caramori

BACKGROUND Radiographic contrast media exposition can cause acute renal function impairment. There is limited and conflicting evidence that hydration with sodium bicarbonate prevents contrast-induced nephropathy (CIN) in patients undergoing cardiac catheterization. OBJECTIVE The present study was aimed at determining whether sodium bicarbonate is superior to hydration with saline to prevent nephropathy in patients at risk undergoing cardiac catheterization. METHODS Three hundred and one patients undergoing coronary angiography or percutaneous coronary intervention with serum creatinine > 1.2mg/dL or glomerular filtration rate (GFR) < 50 ml/min were randomized to receive hydration with sodium bicarbonate starting 1 hour before the procedure and 6 hours after the procedure, or hydration with 0.9% saline. CIN was defined as an increase of 0.5mg/dL in creatinine in 48 h RESULTS Eighteen patients (5.9%) developed contrast induced nephropathy: 9 patients in the bicarbonate group (6.1%) and 9 patients in the saline group (6.0%), p = 0.97. The change in serum creatinine was similar in both groups, 0.01 ± 0.26 mg/dL in the bicarbonate group and 0.01 ± 0.35 mg/dL in the saline group, p = 0.9. No statistical difference was observed between the change in glomerular filtration rate (0.89 ± 9 ml/min vs. 2.29 ± 10 ml/min, p = 0.2 bicarbonate group and saline group, respectively). CONCLUSION Hydration with sodium bicarbonate was not superior to saline to prevent contrast media induced nephropathy in patients at risk undergoing cardiac catheterization.


Arquivos Brasileiros De Cardiologia | 2011

Impact of chronic kidney disease on the efficacy of drug-eluting stents: long-term follow-up study

Vitor Osório Gomes; Patrícia Blaya; Ricardo Lasevitch; Denise Oliveira; Patrícia Hickmann; Luis Felipe Silva Smidt; Carisi Anne Polanczyk; Paulo Ricardo Avancini Caramori

BACKGROUND: Patients with chronic kidney disease (CKD) submitted to coronary angioplasty have higher rates of target lesion revascularization (TLR) and mortality. Drug-eluting stents (DES) are associated with a lower rate of restenosis, compared to bare metal stents (BMS), although data on DES efficacy and safety is limited in patients with CKD. OBJECTIVE: We sought to evaluate the safety and efficacy of DES in patients with significant CKD as compared to patients without normal renal function in a real world registry. METHODS: 504 patients who underwent percutaneous coronary intervention with DES in two centers were included. Outcomes were stratified based on the presence of CKD, defined as a baseline glomerular filtration rate (GFR) < 60 ml/min/1.73 m². RESULTS: The mean follow-up was 22.7 months. CKD was present in 165 patients (32.7%). Patients with CKD were older, had a higher incidence of hypertension and diabetes. CKD patients presented an increased incidence of death (12.3% vs 2.4%, p < 0.001) and myocardial infarction (MI) (7.4% vs 3.3%, p = 0.04) compared to patients without CKD. TLR rates were similar between groups (4.8% vs 5.6%, p = 0.7, CKD and no CKD patients, respectively). Independent predictors of death were CKD (HR 6.93; 2.4 - 19.5, p < 0.001), current smoking (HR 3.66; 1.20 - 11.10, p = 0.02) and diabetes (HR 2.66; 1.03 - 6.60, p = 0.045). CONCLUSION: In this registry, coronary intervention with DES in patients with CKD was associated with similar TLR compared to patients without CKD, demonstrating the efficacy of DES in preventing in-stent restenosis in this patient population. CKD was related to significantly increased MI and mortality rates.BACKGROUND Patients with chronic kidney disease (CKD) submitted to coronary angioplasty have higher rates of target lesion revascularization (TLR) and mortality. Drug-eluting stents (DES) are associated with a lower rate of restenosis, compared to bare metal stents (BMS), although data on DES efficacy and safety is limited in patients with CKD. OBJECTIVE We sought to evaluate the safety and efficacy of DES in patients with significant CKD as compared to patients without normal renal function in a real world registry. METHODS 504 patients who underwent percutaneous coronary intervention with DES in two centers were included. Outcomes were stratified based on the presence of CKD, defined as a baseline glomerular filtration rate (GFR) < 60 ml/min/1.73 m². RESULTS The mean follow-up was 22.7 months. CKD was present in 165 patients (32.7%). Patients with CKD were older, had a higher incidence of hypertension and diabetes. CKD patients presented an increased incidence of death (12.3% vs 2.4%, p < 0.001) and myocardial infarction (MI) (7.4% vs 3.3%, p = 0.04) compared to patients without CKD. TLR rates were similar between groups (4.8% vs 5.6%, p = 0.7, CKD and no CKD patients, respectively). Independent predictors of death were CKD (HR 6.93; 2.4 - 19.5, p < 0.001), current smoking (HR 3.66; 1.20 - 11.10, p = 0.02) and diabetes (HR 2.66; 1.03 - 6.60, p = 0.045). CONCLUSION In this registry, coronary intervention with DES in patients with CKD was associated with similar TLR compared to patients without CKD, demonstrating the efficacy of DES in preventing in-stent restenosis in this patient population. CKD was related to significantly increased MI and mortality rates.


Arquivos Brasileiros De Cardiologia | 2011

Impacto da insuficiência renal crônica na eficácia de stents farmacológicos: estudo de seguimento de longo prazo

Vitor Osório Gomes; Patrícia Blaya; Ricardo Lasevitch; Denise Oliveira; Patrícia Hickmann; Luis Felipe Silva Smidt; Carisi Anne Polanczyk; Paulo Ricardo Avancini Caramori

BACKGROUND: Patients with chronic kidney disease (CKD) submitted to coronary angioplasty have higher rates of target lesion revascularization (TLR) and mortality. Drug-eluting stents (DES) are associated with a lower rate of restenosis, compared to bare metal stents (BMS), although data on DES efficacy and safety is limited in patients with CKD. OBJECTIVE: We sought to evaluate the safety and efficacy of DES in patients with significant CKD as compared to patients without normal renal function in a real world registry. METHODS: 504 patients who underwent percutaneous coronary intervention with DES in two centers were included. Outcomes were stratified based on the presence of CKD, defined as a baseline glomerular filtration rate (GFR) < 60 ml/min/1.73 m². RESULTS: The mean follow-up was 22.7 months. CKD was present in 165 patients (32.7%). Patients with CKD were older, had a higher incidence of hypertension and diabetes. CKD patients presented an increased incidence of death (12.3% vs 2.4%, p < 0.001) and myocardial infarction (MI) (7.4% vs 3.3%, p = 0.04) compared to patients without CKD. TLR rates were similar between groups (4.8% vs 5.6%, p = 0.7, CKD and no CKD patients, respectively). Independent predictors of death were CKD (HR 6.93; 2.4 - 19.5, p < 0.001), current smoking (HR 3.66; 1.20 - 11.10, p = 0.02) and diabetes (HR 2.66; 1.03 - 6.60, p = 0.045). CONCLUSION: In this registry, coronary intervention with DES in patients with CKD was associated with similar TLR compared to patients without CKD, demonstrating the efficacy of DES in preventing in-stent restenosis in this patient population. CKD was related to significantly increased MI and mortality rates.BACKGROUND Patients with chronic kidney disease (CKD) submitted to coronary angioplasty have higher rates of target lesion revascularization (TLR) and mortality. Drug-eluting stents (DES) are associated with a lower rate of restenosis, compared to bare metal stents (BMS), although data on DES efficacy and safety is limited in patients with CKD. OBJECTIVE We sought to evaluate the safety and efficacy of DES in patients with significant CKD as compared to patients without normal renal function in a real world registry. METHODS 504 patients who underwent percutaneous coronary intervention with DES in two centers were included. Outcomes were stratified based on the presence of CKD, defined as a baseline glomerular filtration rate (GFR) < 60 ml/min/1.73 m². RESULTS The mean follow-up was 22.7 months. CKD was present in 165 patients (32.7%). Patients with CKD were older, had a higher incidence of hypertension and diabetes. CKD patients presented an increased incidence of death (12.3% vs 2.4%, p < 0.001) and myocardial infarction (MI) (7.4% vs 3.3%, p = 0.04) compared to patients without CKD. TLR rates were similar between groups (4.8% vs 5.6%, p = 0.7, CKD and no CKD patients, respectively). Independent predictors of death were CKD (HR 6.93; 2.4 - 19.5, p < 0.001), current smoking (HR 3.66; 1.20 - 11.10, p = 0.02) and diabetes (HR 2.66; 1.03 - 6.60, p = 0.045). CONCLUSION In this registry, coronary intervention with DES in patients with CKD was associated with similar TLR compared to patients without CKD, demonstrating the efficacy of DES in preventing in-stent restenosis in this patient population. CKD was related to significantly increased MI and mortality rates.


Arquivos Brasileiros De Cardiologia | 2011

Impacto de la insuficiencia renal crónica en la eficacia de Stents farmacológicos: estudio de seguimiento de largo plazo

Vitor Osório Gomes; Patrícia Blaya; Ricardo Lasevitch; Denise Oliveira; Patrícia Hickmann; Luis Felipe Silva Smidt; Carisi Anne Polanczyk; Paulo Ricardo Avancini Caramori

BACKGROUND: Patients with chronic kidney disease (CKD) submitted to coronary angioplasty have higher rates of target lesion revascularization (TLR) and mortality. Drug-eluting stents (DES) are associated with a lower rate of restenosis, compared to bare metal stents (BMS), although data on DES efficacy and safety is limited in patients with CKD. OBJECTIVE: We sought to evaluate the safety and efficacy of DES in patients with significant CKD as compared to patients without normal renal function in a real world registry. METHODS: 504 patients who underwent percutaneous coronary intervention with DES in two centers were included. Outcomes were stratified based on the presence of CKD, defined as a baseline glomerular filtration rate (GFR) < 60 ml/min/1.73 m². RESULTS: The mean follow-up was 22.7 months. CKD was present in 165 patients (32.7%). Patients with CKD were older, had a higher incidence of hypertension and diabetes. CKD patients presented an increased incidence of death (12.3% vs 2.4%, p < 0.001) and myocardial infarction (MI) (7.4% vs 3.3%, p = 0.04) compared to patients without CKD. TLR rates were similar between groups (4.8% vs 5.6%, p = 0.7, CKD and no CKD patients, respectively). Independent predictors of death were CKD (HR 6.93; 2.4 - 19.5, p < 0.001), current smoking (HR 3.66; 1.20 - 11.10, p = 0.02) and diabetes (HR 2.66; 1.03 - 6.60, p = 0.045). CONCLUSION: In this registry, coronary intervention with DES in patients with CKD was associated with similar TLR compared to patients without CKD, demonstrating the efficacy of DES in preventing in-stent restenosis in this patient population. CKD was related to significantly increased MI and mortality rates.BACKGROUND Patients with chronic kidney disease (CKD) submitted to coronary angioplasty have higher rates of target lesion revascularization (TLR) and mortality. Drug-eluting stents (DES) are associated with a lower rate of restenosis, compared to bare metal stents (BMS), although data on DES efficacy and safety is limited in patients with CKD. OBJECTIVE We sought to evaluate the safety and efficacy of DES in patients with significant CKD as compared to patients without normal renal function in a real world registry. METHODS 504 patients who underwent percutaneous coronary intervention with DES in two centers were included. Outcomes were stratified based on the presence of CKD, defined as a baseline glomerular filtration rate (GFR) < 60 ml/min/1.73 m². RESULTS The mean follow-up was 22.7 months. CKD was present in 165 patients (32.7%). Patients with CKD were older, had a higher incidence of hypertension and diabetes. CKD patients presented an increased incidence of death (12.3% vs 2.4%, p < 0.001) and myocardial infarction (MI) (7.4% vs 3.3%, p = 0.04) compared to patients without CKD. TLR rates were similar between groups (4.8% vs 5.6%, p = 0.7, CKD and no CKD patients, respectively). Independent predictors of death were CKD (HR 6.93; 2.4 - 19.5, p < 0.001), current smoking (HR 3.66; 1.20 - 11.10, p = 0.02) and diabetes (HR 2.66; 1.03 - 6.60, p = 0.045). CONCLUSION In this registry, coronary intervention with DES in patients with CKD was associated with similar TLR compared to patients without CKD, demonstrating the efficacy of DES in preventing in-stent restenosis in this patient population. CKD was related to significantly increased MI and mortality rates.


Revista Brasileira de Cardiologia Invasiva | 2010

Cirurgia não-cardíaca e terapia antiplaquetária em pacientes tratados com stents coronários

Denise Oliveira; Ricardo Lasevitch; Vitor Osório Gomes; Diovane Berleze; Paulo Carmori

ABSTRACT Noncardiac Surgery and Antiplatelet Therapy inPatients with Coronary Stents The increasing incidence of cardiovascular diseases andthe use of bare metal or drug eluting stents have led to anincrease in the use of dual antiplatelet therapy. Thesepatients are frequently submitted to non-cardiac surgeries,requiring adequate perioperative management of antiplateletagents. The strategy of systematic discontinuation of anti-platelet agents prior to surgery increases morbidity andmortality due to thrombotic events, especially in patientswith a high risk of in-stent thrombosis. Data indicate thereis no significant increase of bleeding complications in sur gerieswith low to moderate risk of bleeding carried out whendual antiplatelet therapy is used. Adequate risk assessmentof thrombotic events and surgical bleeding enables theidentification of the most appropriate strategy for the patient.Procedures with low or moderate risk of bleeding must becarried out under antiplatelet therapy, whereas it must bediscontinued in those with high risk of bleeding. Alternatively,one must consider postponing the surgery until antiplatelettherapy is safely discontinued. In general, in patients under-going non-cardiac surgery, the discontinuation of antiplatelettherapy involves cardiovascular risks which are higherthan bleeding complications. Thus, the maintenance ofantiplatelet agents is recommended, except in cases ofsurgery carried out in closed compartments or when the riskof bleeding is unacceptable. We propose an algorithm forthe perioperative management of antiplatelet therapy, takinginto consideration the risks of thrombotic events andbleeding.


Revista Brasileira de Cardiologia Invasiva | 2009

Impacto do diabetes melito na eficácia e na segurança dos stents farmacológicos: registro com até cinco anos de seguimento

Luis Felipe Silva Smidt; Rodrigo Bodanese; Vitor Osório Gomes; Ricardo Lasevitch; Christiano Barcellos; Denise Oliveira; Marina Resener de Morais; Patrícia Hickmann; Ana Maria Rocha Krepsky; Marcelo Emilio Arndt; Carisi Anne Polanczyk; Luiz Carlos Bodanese; Paulo Caramori

BACKGROUND: Diabetic patients are at high risk of recurrent coronary events. Drug eluting stents (DES) reduce restenosis and target lesion revascularization in both diabetic and non-diabetic patients. However, there are limited data on the long-term safety and efficacy of DES in diabetic patients. The objective of this study was to evaluate the long-term clinical outcome in this high risk population. METHOD: From May 2002 to April 2007, all patients undergoing coronary intervention with DES in two hospitals were included in the study and were followed-up for up to 5 years. RESULTS: A total of 611 patients with mean age of 63.5 ± 11.2 years were included in the registry. Diabetic patients (n = 204, 33.4%) included a smaller proportion of males, greater prevalence of hypertension, chronic renal failure, and smaller coronary reference diameter when compared to non-diabetic patients. During the follow-up, diabetics had a higher probability of combined adverse cardiac events (19.7% vs. 13.4%; P = 0.04), as a result of death (7.4% vs. 2.3%; P = 0.003), acute myocardial infarction (5.9% vs. 3.1%; P = 0.10) and definitive/probable stent thrombosis (3.9% vs. 1.3%; P = 0.04). Target vessel and target lesion revascularization, however, were not different between the groups (10.9% vs. 9.8%; P = 0.68 and 3.4% vs. 5.1%; P= 0.35, respectively). The presence of diabetes mellitus was an independent predictor of death [odds ratio (OR) 2.41; 95% confidence interval (95% CI) 1.02-5.78; P = 0.05) but not of stent thrombosis (OR 2.41; 95% CI 0.76-7.61; P = 0.13) in our patients. CONCLUSIONS: The outcomes of this study show that in patients undergoing DES implantation, the presence of diabetes was associated to higher mortality rates, acute myocardial infarction and stent thrombosis when compared to non-diabetics. The finding of similar target lesion revascularization rates in diabetic and non-diabetic patients is promising and suggests the efficacy of percutaneous revascularization with DES implantation in this population.


Cardiovascular Revascularization Medicine | 2009

Efficacy and safety of drug-eluting stents in patients with chronic kidney disease

Patrícia Blaya; Vitor Osório Gomes; Denise Oliveira; Luis Felipe Silva Smidt; Ricardo Lasevitch; Patrícia Hickmann; Christiano Barcellos; Marina Resener de Morais; Carisi Anne Polanczyk; Paulo Caramori


Archive | 2009

Segurança e eficácia dos stents farmacológicos sirolimus, paclitaxel e zoratolimus na prática clínica diária

Luis Felipe Silva Smidt; Vitor Osório Gomes; Denise Oliveira; Marcelo Emilio Arndt; Rodrigo Bodanese; Cristiano Barcellos; Marina Resener de Morais; Patrícia Blaya; Patrícia Hickmann; Ricardo Lasevitch; Carisi Anne Polanczyk; Paulo Caramori


Archive | 2009

Eficácia e segurança dos stents farmacológicos em pacientes diabéticos : registro de 5 anos seguimento

Luis Felipe Silva Smidt; Rodrigo Bodanese; Denise Oliveira; Marcelo Emilio Arndt; Cristiano Machado de Oliveira; Marina Resener de Morais; Patrícia Hickmann; Vitor Osório Gomes; Ricardo Lasevitch; Luiz Carlos Bodanese; Carisi Anne Polanczyk; Paulo Caramori


Archive | 2008

Eficácia e segurança dos stents farmacológicos em pacientes com insuficiência renal crônica

Luis Felipe Silva Smidt; Patrícia Blaya; Vitor Osório Gomes; Denise Oliveira; Cristiano Barcellos; Marina Resener de Morais; Ricardo Lasevitch; Carisi Anne Polanczyk; Paulo Caramori

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Ricardo Lasevitch

Pontifícia Universidade Católica do Rio Grande do Sul

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Vitor Osório Gomes

Pontifícia Universidade Católica do Rio Grande do Sul

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Carisi Anne Polanczyk

Universidade Federal do Rio Grande do Sul

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Luis Felipe Silva Smidt

Pontifícia Universidade Católica do Rio Grande do Sul

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Patrícia Hickmann

Pontifícia Universidade Católica do Rio Grande do Sul

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Patrícia Blaya

Pontifícia Universidade Católica do Rio Grande do Sul

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Marina Resener de Morais

Pontifícia Universidade Católica do Rio Grande do Sul

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Paulo Caramori

Pontifícia Universidade Católica do Rio Grande do Sul

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Marcelo Emilio Arndt

Pontifícia Universidade Católica do Rio Grande do Sul

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Paulo Ricardo Avancini Caramori

Pontifícia Universidade Católica do Rio Grande do Sul

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