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Dive into the research topics where Deniz Güzelsoy is active.

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Featured researches published by Deniz Güzelsoy.


Cardiovascular Ultrasound | 2007

The effects of atorvastatin therapy on endothelıal function in patients with coronary artery disease

Ahmet Yildiz; M Akif Cakar; Murat Baskurt; Baris Okcun; Deniz Güzelsoy; Ugur Coskun

BackgroundStatins improve the endothelial function in patients with coronary artery disease (CAD). However, they contribute to the substantial decrease in coronary heart disease by reducing plasma cholesterol levels. They also, reduce oxidative stress, stabilize the atherosclerotic plaque and inhibit inflammatory response. These functions of statins have been briefly described as pleiotropic effects. The aim of our study was to evaluate the effect of atorvastatin therapy on endothelial functions in patients with CAD.MethodsFourty-nine patients (40 men, 9 women, mean age 59 +/- 11 years) with diagnosed CAD were selected as the study group. The patients were given 10 mg/day atorvastatin for 12 weeks. If the target cholesterol levels has not been achieved 6 weeks after the treatment, then the daily atorvastatin dosage has been increased. The endothelial function was evaluated by flow mediated dilatation (FMD) of the brachial artery.ResultsIt has been figured out that 12 weeks later, atorvastatin caused a statistically significant decrease in the plasma levels of LDL-cholesterol and total cholesterol (p < 0,0001). Meanwhile, it was determined that the FMD got statistically significant improved 12 weeks after the atorvastatin therapy (8,1%–4,2%, p < 0,001). However there was no statistically significant change in non-endothelium dependent dilatation (NID).ConclusionEndothelium derived vasodilatation (EBD), which was non-invasively detected via brachial artery ultrasonography, had statistically significant improvment within 12 weeks of atorvastatin therapy whereas non-endothelium dependent dilatation (NID) had no change.


American Journal of Cardiology | 1988

Acute and sustained antianginal effects of nitroglycerin patches: Objective evaluation with training-effect-eliminated exercise performance index

Hasan Dogar; Deniz Güzelsoy; Nazmi Gültekin; Nilgün Gürses; Cem'i Demiroglu

A randomized within-patient double-blind acute and sustained study was performed to compare transdermal nitroglycerin (NTG) patches (5 and 10 mg) and matching placebo in 10 patients with chronic stable angina pectoris confirmed on exercise thallium scintigraphy or coronary angiography, or both. Patients performed treadmill tests 2 and 24 hours after application of patches on the first and last days of each of the 3 treatment periods. Effects caused by sequence of treatments and training with serial testing were prominent so the changes in the well-known parameters did not favor either of the active doses over placebo. Quantification of training effects and its subtraction from performance index disclosed that 10 mg of transdermal NTG caused significant increase in performance in both the acute and sustained stages of therapy in comparison to pretreatment performance. This was not observed with 5 mg and placebo treatments. To our knowledge, this is the first trial to study the efficacy of transdermal NTG with a more objective parameter that permitted elimination of training effects of serial exercise testing.


The Cardiology | 1994

Long-Term Prognosis after a First Myocardial Infarction in Turkey: Determinants of Mortality and Reinfarction

Hüsniye Yüksel; Deniz Güzelsoy; Nuran Yazicioğlu; Mustafa Şenocak; Muzaffer Öztürk; Cem'i Demiroglu

Long-term prognosis of a first myocardial infarction and factors associated with late cardiac mortality and reinfarction were studied in 718 survivors. Patients have been followed up for 1-10 years (mean 57.6 +/- 39.6 months). None of the patients underwent coronary bypass surgery in the follow-up period. Cumulative mortality rates were 8.6% in the first year, 17.9% in 3 years, 26.4% in 5 years and 36.5% in 10 years. The type and site of myocardial infarction (Q-wave versus non-Q-wave and anterior versus infero-posterior) were found to have no independent prognostic importance. The cardiac mortality was best predicted by the occurrence of congestive heart failure in the coronary care unit. Other determinants of late outcome were the presence of ventricular arrhythmias, left bundle branch block, and the occurrence of stable or unstable angina pectoris or reinfarction during the follow-up period. Usage of antiplatelet or anticoagulant drugs was not found to affect mortality. Reinfarction rates were 4, 9.9, 15.5 and 28% in 1, 3, 5 and 10 years, respectively, and no relation was found between the type and location of myocardial infarction and reinfarction rate. Reinfarction was higher in patients receiving anticoagulants and in patients with postmyocardial infarction angina. Our findings suggest that the prognosis of patients with a first acute myocardial infarction in Turkey is not different from that in Western populations and factors influencing prognosis are similar to those previously reported.


Echocardiography-a Journal of Cardiovascular Ultrasound and Allied Techniques | 2002

Predictors for maintenance of sinus rhythm after cardioversion in patients with nonvalvular atrial fibrillation.

Baris Okcun; Zerrin Yigit; M. Serdar Küçükoğlu; Haşim Mutlu; Vedat Sansoy; Deniz Güzelsoy; Sinan Üner


American Journal of Cardiology | 2004

Effects of Atorvastatin (10 mg) on Hemostatic and Inflammatory Parameters in Hyperlipidemic Patients With Angiographically Proven Coronary Artery Disease

Abdullah Tekin; Göknur Tekin; Deniz Güzelsoy; Ayşem Kaya; Çiğdem Gürel; Zerrin Yigit; Turgut Ulutin


Japanese Heart Journal | 2003

The safety of low-molecular weight heparins for the prevention of thromboembolic events after cardioversion of atrial fibrillation.

Zerrin Yigit; M. Serdar Küçükoğlu; Baris Okcun; Vedat Sansoy; Deniz Güzelsoy


Japanese Heart Journal | 2003

Restoring sinus rhythm improves excessive heart rate response to exercise in patients with atrial fibrillation.

Zerrin Yigit; Hülya Akdur; Ümit Arabaci; Hulya Nilgun Gurses; Deniz Güzelsoy


Japanese Heart Journal | 2002

Comparison of cardiovascular responses to isometric (static) and isotonic (dynamic) exercise tests in chronic atrial fibrillation.

Hülya Akdur; Zerrin Yigit; Ümit Arabaci; Mine Gülden Polat; Hulya Nilgun Gurses; Deniz Güzelsoy


International Heart Journal | 2005

The Changes in Circulating Levels of Vasoactive Intestinal Polypeptide During Exercise and Its Reproducibility for Detection of Myocardial Ischemia

Sembol Turkmen; Serkan Dogan; Irfan Barutcu; Ilke Sipahi; Hatice Ayabakan; Ali Metin Esen; Ozlem Esen; Deniz Güzelsoy


Türk Kardiyoloji Derneği Arşivi | 2002

Sinüs Ritmine Döndürülen Atriyal Fibrilasyonlu Hastalarda İzometrik ve İzotonik Egzersize Olan Kardiyovasküler Yanıtlardaki Düzelme

Zerrin Yiğit; Y.Fzt.Hülya Akdur; Ümit Arabaci; Vedat Sansoy; Fzt.Nilgün Gürses; Deniz Güzelsoy

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