Derek Trumbo

N2A: a computational tool for modeling from neurons to algorithms.

The exponential increase in available neural data has combined with the exponential growth in computing (“Moores law”) to create new opportunities to understand neural systems at large scale and high detail. The ability to produce large and sophisticated simulations has introduced unique challenges to neuroscientists. Computational models in neuroscience are increasingly broad efforts, often involving the collaboration of experts in different domains. Furthermore, the size and detail of models have grown to levels for which understanding the implications of variability and assumptions is no longer trivial. Here, we introduce the model design platform N2A which aims to facilitate the design and validation of biologically realistic models. N2A uses a hierarchical representation of neural information to enable the integration of models from different users. N2A streamlines computational validation of a model by natively implementing standard tools in sensitivity analysis and uncertainty quantification. The part-relationship representation allows both network-level analysis and dynamical simulations. We will demonstrate how N2A can be used in a range of examples, including a simple Hodgkin-Huxley cable model, basic parameter sensitivity of an 80/20 network, and the expression of the structural plasticity of a growing dendrite and stem cell proliferation and differentiation.

Determining the optimal time on x-ray analysis for Transportation Security Officers.

The Transportation Security Administration has a large workforce of Transportation Security Officers, most of whom perform interrogation of x-ray images at the passenger checkpoint. To date, TSOs on the x-ray have been limited to a 30-min session at a time, however, it is unclear where this limit originated. The current paper outlines methods for empirically determining if that 30-min duty cycle is optimal and if there are differences between individual TSOs. This work can inform scheduling TSOs at the checkpoint and can also inform whether TSOs should continue to be cross-trained (i.e., performing all 6 checkpoint duties) or whether specialization makes more sense.

Exploratory Analysis of Visual Search Data

Visual search data describe people’s performance on the common perceptual problem of identifying target objects in a complex scene. Technological advances in areas such as eye tracking now provide researchers with a wealth of data not previously available. The goal of this work is to support researchers in analyzing this complex and multimodal data and in developing new insights into visual search techniques. We discuss several methods drawn from the statistics and machine learning literature for integrating visual search data derived from multiple sources and performing exploratory data analysis. We ground our discussion in a specific task performed by officers at the Transportation Security Administration and consider the applicability, likely issues, and possible adaptations of several candidate analysis methods.

Data Privacy and Security Considerations for Personal Assistants for Learning (PAL)

A hypothetical scenario is utilized to explore privacy and security considerations for intelligent systems, such as a Personal Assistant for Learning (PAL). Two categories of potential concerns are addressed: factors facilitated by user models, and factors facilitated by systems. Among the strategies presented for risk mitigation is a call for ongoing, iterative dialog among privacy, security, and personalization researchers during all stages of development, testing, and deployment.

The Controlled, Large Online Social Experimentation Platform (CLOSE)

We present a new platform to do online, social influence experiments – the Controlled, Online Social Experimentation (CLOSE) system. We describe it’s development, potential uses and justification for use. The CLOSE platform can be used to do long term (weeks to months) experiments in which we can manipulate the interaction networks (within the experiment) of a diverse (drawn from Amazon Mechanical Turk (AMT)) subject pool.

Neurons to algorithms LDRD final report.

Over the last three years the Neurons to Algorithms (N2A) LDRD project teams has built infrastructure to discover computational structures in the brain. This consists of a modeling language, a tool that enables model development and simulation in that language, and initial connections with the Neuroinformatics community, a group working toward similar goals. The approach of N2A is to express large complex systems like the brain as populations of a discrete part types that have specific structural relationships with each other, along with internal and structural dynamics. Such an evolving mathematical system may be able to capture the essence of neural processing, and ultimately of thought itself. This final report is a cover for the actual products of the project: the N2A Language Specification, the N2A Application, and a journal paper summarizing our methods.