Deren Özcan

Liver transplant recipient with concomitant cutaneous and visceral leishmaniasis

Abstract:  Diagnosis of leishmaniasis in immunosuppressed patients may be a serious challenge for physicians because of the major clinical and laboratory differences with immunocompetent patients. In immunosuppressed patients, the disease is characterized usually by disseminated visceral involvement, atypical cutaneous lesions and persistent negativity of diagnostic tests. Here, we report an eight‐yr‐old liver transplant recipient with concomitant cutaneous and visceral leishmaniasis in whom the cutaneous lesion led to the diagnosis of systemic involvement.

The role of human herpesvirus‐6, Epstein–Barr virus and cytomegalovirus infections in the etiopathogenesis of different types of cutaneous drug reactions

Background  Recently, it has been recognized that drug‐induced hypersensitivity syndrome (DIHS) is associated with reactivation of human herpesvirus‐6 (HHV‐6), Epstein–Barr virus (EBV) and cytomegalovirus (CMV). However, whether those viruses have a role in the development of cutaneous drug reactions (CDRs) other than DIHS is not known.

Mucocutaneous disorders in renal transplant recipients receiving sirolimus-based immunosuppressive therapy: a prospective, case–control study

Sirolimus (SRL) has some dermatologic complications including acneiform eruptions, edema, aphthous ulceration, and onychopathy. However, controlled studies reporting the prevalence and clinical characteristics of mucocutaneous disorders are scarce.

Multiple subcutaneous nodules leading to the diagnosis of pulmonary aspergillosis in a renal transplant recipient

Abstract: Aspergillosis is the second most frequent opportunistic fungal infection in solid organ transplant recipients; however, cutaneous aspergillosis occurs very rarely. Herein, we report a 34‐yr‐old male renal transplant recipient with secondary cutaneous aspergillosis due to Aspergillus fumigatus in whom cutaneous lesions led to the correct diagnosis. To the best of our knowledge, this is the first case of secondary cutaneous aspergillosis reported in the setting of a solid organ transplantation.

Concurrence of alopecia areata and vitiligo at the same anatomical site.

Both alopecia areata and vitiligo are common skin disorders that are considered to be caused by an autoimmune response targeted to hair follicle and melanocyte antigens, respectively. The association of these two diseases in the same patient is well known, however, coexistence of alopecia areata and vitiligo within the same lesion is very rare. Herein, we report an 8‐year‐old boy who had colocalization of alopecia areata and vitiligo on the frontal portion of his scalp.

Acquired aquagenic syringeal acrokeratoderma: A case series of 10 patients

Aquagenic syringeal acrokeratoderma is a rare acquired disorder that predominantly affects young women. It is most commonly localised on the palms. It is characterised by translucent papules, oedematous plaques and keratoderma developing after brief exposure to water and resolving shortly after drying. We have observed 10 patients with this disorder within 13 months. We think that aquagenic syringeal acrokeratoderma is a more common condition than was originally anticipated as one can easily underdiagnose this entity due to the transient nature of its clinical findings.

A Collodion Baby with Facial Dysmorphism, Limb Anomalies, Pachygyria and Genital Hypoplasia: A Mild Form of Neu-Laxova Syndrome or a New Entity?

Neu-Laxova syndrome is a rare, lethal, autosomal recessive disorder characterized by intrauterine growth retardation, central nervous system anomalies, skin findings, such as ichthyosis, edema, collodion baby and harlequin fetus, facial dysmorphic features, limb anomalies and genital hypoplasia. Although it is generally a lethal condition, cases of such patients who lived beyond 6 months and 10 months of age have been reported. Here, we describe an 8-year-old boy who was born with collodion membrane, facial dysmorphic features, limb anomalies, genital hypoplasia and pachygyria. He had no major health problems over the course of 8 years of follow-up, except for mild mental/motor retardation, ichthyosis, facial dysmorphic features and limb anomalies. Based on these features, we suggest that because Neu-Laxova syndrome represents a heterogeneous phenotype, our case may be a milder variant of this syndrome or a new genetic entity.

Lentiginosis within plaques of hypopigmented linear atrophoderma of Moulin: another example of twin spotting?

the disease that affects mostly women and African patients. Ulcers develop within preexisting lesions, such as papules or nodules, but may also occur de novo. The lower extremities are most commonly involved, but lesions may occur elsewhere (upper limbs, trunk, face). Non-caseating granulomas within the ulcers and the surrounding tissue assess the diagnosis. Ulcerative disease is generally associated with systemic involvement. Our patient had marked cytopenia and splenomegaly. Splenomegaly occurs in up to 20% of the patients and mainly in black patients. Splenomegaly is usually homogeneous, but multiple nodular lesions pattern may mimic other worrisome diagnoses (lymphoma, metastases, tuberculosis), and may range up to 16 cm. It is most likely underestimated in the absence of clinical symptoms and systematic abdominal imaging (ultrasound or CT scan). Pain and rupture are exceptional. Thrombopenia during sarcoidosis may be related to different mechanisms: (i) hypersplenism/splenomegaly; (ii) bone marrow granulomas; or (iii) auto-immune thrombocytopenic purpura. Thrombocytopenia is one of the most common biological features associated with splenomegaly. Cutaneous manifestations are often associated with splenomegaly. Corticosteroid therapy displayed an excellent efficacy on all signs. Our case acts as a reminder that cutaneous ulcers of the lower limbs may be the presenting symptoms of systemic sarcoidosis and reveal unexpected visceral involvement, here through lymph nodes enlargement, lung involvement, hepatomegaly, splenomegaly, and cytopenia.

Visceral leishmaniasis with cutaneous dissemination in a renal transplant recipient

ejd.2013.2168 Auteur(s) : Sedef Yucel1, Deren Ozcan1, Deniz Seckin1 denizs@baskent-ank.edu.tr, Adil M. Allahverdiyev2, Fazilet Kayaselcuk3, Mehmet Haberal4 1 Department of Dermatology, 4 Department of General Surgery, Baskent University Faculty of Medicine, 5. sokak No. 48, Bahccelievler 06490 Ankara, Turkey 2 Department of Bioengineering, Yildiz Technical University, Istanbul, Turkey 3 Department of Pathology, Baskent University Faculty of Medicine, Adana, Turkey A 34-year-old male was referred [...]

Non-oral mucosal involvement of pemphigus vulgaris: Tzanck smear test as a handy diagnostic tool

References 1 Kawakami T, Soma Y. Correlation of livedo racemosa, cutaneous inflammatory plaques, and antiphospholipid antibodies in patients with cutaneous polyarteritis nodosa. Medicine (Baltimore) 2011; 90: 119–124. 2 Jennette JC, Falk RJ, Bacon PA, et al. 2012 Revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides. Arthritis Rheum 2013; 65: 1–11. 3 de Groot K, Harper L, Jayne DR, et al. Pulse versus daily oral cyclophosphamide for induction of remission in antineutrophil cytoplasmic antibody-associated vasculitis: a randomized trial. Ann Intern Med 2009; 150: 670–680. 4 Kawakami T, Yamazaki M, Mizoguchi M, et al. High titer of anti-phosphatidylserine-prothrombin complex antibodies in patients with cutaneous polyarteritis nodosa. Arthritis Rheum 2007; 57: 1507–1513. 5 Takeuchi S, Kimura S, Soma Y, et al. Lysosomalassociated membrane protein-2 plays an important role in the pathogenesis of primary cutaneous vasculitis. Rheumatology (Oxford) 2013; 52: 1592–1598. 6 Kawakami T, Okudaira O, Okano T, et al. Treatment for cutaneous arteritis patients with mononeuritis multiplex and elevated C-reactive protein. J Dermatol 2013; 40: 955–961. 7 Hoffman GS, Kerr GS, Leavitt RY, et al. Wegener granulomatosis: an analysis of 158 patients. Ann Intern Med 1992; 116: 488–498. 8 Guillevin L, Cordier JF, Lhote F, et al. A prospective, multicenter, randomized trial comparing steroids and pulse cyclophosphamide versus steroids and oral cyclophosphamide in the treatment of generalized Wegeners granulomatosis. Arthritis Rheum 1997; 40: 2187–2198. 9 Jayne D, Rasmussen N, Andrassy K, et al. A randomized trial of maintenance therapy for vasculitis associated with antineutrophil cytoplasmic autoantibodies. N Engl J Med 2003; 349: 36–44. Non-oral mucosal involvement of pemphigus vulgaris: