DeWayne Roberts
National Foundation for Cancer Research
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Publication
Featured researches published by DeWayne Roberts.
Science | 1965
David Kessel; Thomas C. Hall; DeWayne Roberts; Isidore Wodjnsky
Methotrexate-promoted survival of mice bearing different transplantable leukemias was compared with uptake of the drug by leukemia cells in vitro. A high degree of correlation (r2 = 0.88) showed that uptake may be a major determinant of the antitumor activity of methotrexate against transplantable mouse leukemias.
Cancer | 1967
DeWayne Roberts; Thomas C. Hall
The effect of methotrexate on dihydrofolate reductase activity of normal and leukemic human leukocytes has been studied with folate as enzyme substrate. In a delayed effect, methotrexate increased dihydrofolate reductase activity in normal leukocytes and in chronic myelogenous leukemia. Enzyme activity was elevated in two of seven patients with chronic lymphocytic leukemia, but not in patients with acute leukemia. The administration of methotrexate inhibits the “drug‐induced” elevation of enzyme activity in normal leukocytes and in chronic myelogenous leukemia. The incorporation of deoxyuridine and thymidine into DNA was inhibited by methotrexate in childhood leukemia. In adults with leukemia, incorporation of deoxyuridine but not thymidine was inhibited. This difference beween adults and children, which must reflect a second effect of methotrexate, may occur as a result of the inhibition of purine synthesis in children.
Biochemistry | 1966
DeWayne Roberts
Cancer Research | 1968
David Kessel; Thomas C. Hall; DeWayne Roberts
Cancer Research | 1974
Charles B. Pratt; DeWayne Roberts; Ellen Shanks; Ellen Loehr Warmath
Cancer Research | 1975
Naresh C. Misra; DeWayne Roberts
Cancer Research | 1965
DeWayne Roberts; Isidore Wodinsky; Thomas C. Hall
Cancer Research | 1980
DeWayne Roberts; Susan Hilliard; Charles Peck
Cancer Research | 1969
DeWayne Roberts; Thomas C. Hall; David Rosenthal; Ann Penta; Ellen V. Loehr; Jean Anderson; Karen Steinberg
Cancer Research | 1969
DeWayne Roberts; Thomas C. Hall; Ann Penta; Ellen V. Loehr; Jean Anderson; Karen Steinberg; Marilyn Shapiro