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Dive into the research topics where DeWayne Roberts is active.

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Featured researches published by DeWayne Roberts.


Science | 1965

Uptake as a determinant of methotrexate response in mouse leukemias.

David Kessel; Thomas C. Hall; DeWayne Roberts; Isidore Wodjnsky

Methotrexate-promoted survival of mice bearing different transplantable leukemias was compared with uptake of the drug by leukemia cells in vitro. A high degree of correlation (r2 = 0.88) showed that uptake may be a major determinant of the antitumor activity of methotrexate against transplantable mouse leukemias.


Cancer | 1967

Dihydrofolate reductase activity and deoxynucleoside incorporation into DNA of human leukocytes. Relation to methotrexate administration

DeWayne Roberts; Thomas C. Hall

The effect of methotrexate on dihydrofolate reductase activity of normal and leukemic human leukocytes has been studied with folate as enzyme substrate. In a delayed effect, methotrexate increased dihydrofolate reductase activity in normal leukocytes and in chronic myelogenous leukemia. Enzyme activity was elevated in two of seven patients with chronic lymphocytic leukemia, but not in patients with acute leukemia. The administration of methotrexate inhibits the “drug‐induced” elevation of enzyme activity in normal leukocytes and in chronic myelogenous leukemia. The incorporation of deoxyuridine and thymidine into DNA was inhibited by methotrexate in childhood leukemia. In adults with leukemia, incorporation of deoxyuridine but not thymidine was inhibited. This difference beween adults and children, which must reflect a second effect of methotrexate, may occur as a result of the inhibition of purine synthesis in children.


Biochemistry | 1966

An Isotopic Assay for Thymidylate Synthetase

DeWayne Roberts


Cancer Research | 1968

Modes of Uptake of Methotrexate by Normal and Leukemic Human Leukocytes in Vitro and Their Relation to Drug Response

David Kessel; Thomas C. Hall; DeWayne Roberts


Cancer Research | 1974

Clinical Trials and Pharmacokinetics of Intermittent High-Dose Methotrexate-“Leucovorin Rescue” for Children with Malignant Tumors

Charles B. Pratt; DeWayne Roberts; Ellen Shanks; Ellen Loehr Warmath


Cancer Research | 1975

Inhibition by 4′-Demethyl-epipodophyllotoxin 9-(4,6-O-2-Thenylidene-β-d-glucopyranoside) of Human Lymphoblast Cultures in G2 Phase of the Cell Cycle

Naresh C. Misra; DeWayne Roberts


Cancer Research | 1965

Studies on Folic Reductase III. The Level of Enzyme Activity and Response to Methotrexate of Transplantable Mouse Tumors

DeWayne Roberts; Isidore Wodinsky; Thomas C. Hall


Cancer Research | 1980

Sedimentation of DNA from L1210 Cells after Treatment with 4′-Demethylepipodophyllotoxin-9-(4,6-O-2-thenylidene-β-d-glucopyranoside) or 1-β-d-Arabinofuranosylcytosine or Both Drugs

DeWayne Roberts; Susan Hilliard; Charles Peck


Cancer Research | 1969

Coordinated Changes in Biochemical Patterns: The Effect of Cytosine Arabinoside and Methotrexate on Leukocytes from Patients with Acute Granulocytic Leukemia

DeWayne Roberts; Thomas C. Hall; David Rosenthal; Ann Penta; Ellen V. Loehr; Jean Anderson; Karen Steinberg


Cancer Research | 1969

Enzyme activities and deoxynucleoside utilization of leukemic leukocytes in relation to drug therapy and resistance.

DeWayne Roberts; Thomas C. Hall; Ann Penta; Ellen V. Loehr; Jean Anderson; Karen Steinberg; Marilyn Shapiro

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Thomas C. Hall

National Foundation for Cancer Research

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Ellen V. Loehr

St. Jude Children's Research Hospital

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Charles B. Pratt

St. Jude Children's Research Hospital

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Ellen Shanks

St. Jude Children's Research Hospital

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Miles Hacker

Grand Valley State University

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Taisheng Lee

St. Jude Children's Research Hospital

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Thomas L. Avery

St. Jude Children's Research Hospital

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