Didier Moukoko
University of Montpellier
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Clinical Biomechanics | 2018
Didier Moukoko; Didier Pourquier; Cécile Genovesio; Simon Thezenas; Patrick Chabrand; Sandrine Roffino; Martine Pithioux
Background: Circulating mesenchymal stem cells contribute to bone repair. Their incorporation in fracture callus is correlated to their bioavailability. In addition, Granulocyte‐colony stimulating factor induces the release of vascular and mesenchymal progenitors. We hypothesized that this glycoprotein stimulates fracture healing, and analyzed the effects of its administration at low doses on bone healing. Methods: 27 adult male Sprague‐Dawley rats underwent mid‐femur osteotomy stabilized by centromedullar pinning. In a post (pre) operative group, rats were subcutaneously injected with 5 &mgr;g/kg per day of Granulocyte‐colony stimulating factor for 5 days after (before) surgery. In a control group, rats were injected with saline solution for 5 days immediately after surgery. A radiographic consolidation score was calculated. At day 35, femurs were studied histologically and underwent biomechanical tests. Findings: 5 weeks after surgery, mean radiographic scores were significantly higher in the Preop group 7.75 (SD 0.42) and in the Postop group 7.67 (SD 0.52) than in the control group 6.75 (SD 0.69). Biomechanical tests showed femur stiffness to be more than three times higher in both the Preop 109.24 N/mm (SD 51.86) and Postop groups 100.05 N/mm (SD 60.24) than in control 32.01 N/mm (SD 15.78). Mean maximal failure force was twice as high in the Preop group 68.66 N (SD 27.78) as in the control group 34.21 N (SD 11.79). Histological results indicated a later consolidation process in control than in treated groups. Interpretation: Granulocyte‐colony stimulating factor injections strongly stimulated early femur fracture healing, indicating its potential utility in human clinical situations such as programmed osteotomy and fracture. HighlightsStudy the effects of granulocyte‐colony stimulating factor low dose on bone repairGranulocyte‐colony stimulating factor accelerates femur consolidation process.A three‐fold increase in stiffness for pre or post‐surgically treated ratsDoubled maximal failure force for pre‐surgically treated rats
Medical & Biological Engineering & Computing | 2007
Didier Moukoko; Martine Pithioux; Patrick Chabrand
Archive | 2003
Didier Pourquier; Didier Moukoko
Archive | 2011
Didier Pourquier; Didier Moukoko
Revue de Chirurgie Orthopédique et Traumatologique | 2015
Didier Moukoko; Martine Pithioux; Sandrine Roffino; Didier Pourquier; Patrick Chabrand
Revue de Chirurgie Orthopédique et Traumatologique | 2011
Didier Moukoko; D. Pourquier; M. Pithioux; P. Chabrand
Revue de Chirurgie Orthopédique et Traumatologique | 2010
Didier Moukoko; D. Pourquier; M. Pithioux; P. Chabrand
Congrès français de mécanique | 2009
Remy Casanova; Didier Moukoko; Martine Pithioux; David Marchat; Patrick Chabrand
Journal of Biomechanics | 2008
Remy Casanova; Didier Moukoko; Martine Pithioux; Patrick Chabrand; Hassan Zahouani
Revue De Chirurgie Orthopedique Et Reparatrice De L Appareil Moteur | 2007
Didier Moukoko; Martine Pithioux; Patrick Chabrand; H. Zahouani; Roberto Vargiolu