Dieter Dorsch

Ekkehard Bartmann; Dieter Dorsch; Ulrich Finkenzeller

Abstract Liquid crystalline compounds with various polar terminal groups containing fluorine have been prepared (see below formula 1 with Z = S‒CHF2, S‒CF3, SO‒CHF2, SO‒CF3, SO2‒CHF2, SO2‒CF3, SO2F, OCH2CF3, CO‒OCH2CF3, CO‒CF3, CO‒CF2Cl, CO‒CF2H, CO‒CF2‒CH3, CO‒CF2‒C3H7). The synthesis of these compounds is outlined here and their physical properties (phase transitions, dielectric anisotropy, birefringence, viscosity) are discussed.

Dieter Dorsch; Werner Mederski; Norbert Beier; Inge Lues; Klaus-Otto Dr. Minck; Pierre Schelling

The syntheses and angiotensin II antagonistic activities of novel (6-oxo-3-pyridazinyl)-benzimidazole derivatives are reported. Evaluation of the structure-activity relationships led to the discovery of potent orally active antihypertensive compounds.

Dieter Dorsch; Werner Mederski; Mathias Osswald; Norbert Beier; Pierre Schelling

1,2,3,4-Tetrahydro-2,4-pyrimidinedione (uracil) is a valuable nucleus for the construction of potent antagonists of the AT1 angiotensin II receptor. Various synthetic routes were applied in order to introduce a wide range of different groups at the N3-nitrogen and to obtain condensed uracil derivatives as well. 121 with a N,N-dimethylacetamide residue at N3 was the most potent compound with an IC50 of 0.65 nM.

Horst Juraszyk; Dieter Dorsch; Werner Mederski; Christos Tsaklakidis; Christopher Bames; Johannes Gleitz

Dieter Dorsch; Werner Mederski; Mathias Osswald; Pierre Schelling; Norbert Beier; Ingeborg Lues; Klaus-Otto Dr. Minck

Werner Mederski; Dieter Dorsch; Heinz-Hermann Bokel; Norbert Beier; Ingeborg Lues; Pierre Schelling

Rolf Gericke; Manfred Baumgarth; Dieter Dorsch; Norbert Beier; Klaus-Otto Dr. Minck; Ingeborg Lues

Dieter Dorsch; Horst Juraszyk; Hanns Wurziger; Sabine Bernotat-Danielowski; Guido Melzer

Bernhard Scheuble; Bernhard Rieger; Dieter Dorsch

Werner Mederski; Rolf Gericke; Dieter Dorsch; Markus Klein; Norbert Beier; Florian Lang