Dieter Dorsch

Liquid Crystals with Polar Substituents Containing Fluorine: Synthesis and Physical Properties

Abstract Liquid crystalline compounds with various polar terminal groups containing fluorine have been prepared (see below formula 1 with Z = S‒CHF2, S‒CF3, SO‒CHF2, SO‒CF3, SO2‒CHF2, SO2‒CF3, SO2F, OCH2CF3, CO‒OCH2CF3, CO‒CF3, CO‒CF2Cl, CO‒CF2H, CO‒CF2‒CH3, CO‒CF2‒C3H7). The synthesis of these compounds is outlined here and their physical properties (phase transitions, dielectric anisotropy, birefringence, viscosity) are discussed.

(6-oxo-3-pyridazinyl)-benzimidazoles as potent angiotensin II receptor antagonists

The syntheses and angiotensin II antagonistic activities of novel (6-oxo-3-pyridazinyl)-benzimidazole derivatives are reported. Evaluation of the structure-activity relationships led to the discovery of potent orally active antihypertensive compounds.

URACIL-BASED ANGIOTENSIN II RECEPTOR ANTAGONISTS

1,2,3,4-Tetrahydro-2,4-pyrimidinedione (uracil) is a valuable nucleus for the construction of potent antagonists of the AT1 angiotensin II receptor. Various synthetic routes were applied in order to introduce a wide range of different groups at the N3-nitrogen and to obtain condensed uracil derivatives as well. 121 with a N,N-dimethylacetamide residue at N3 was the most potent compound with an IC50 of 0.65 nM.