Dieter Hoffmann
Aventis Pharma
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Publication
Featured researches published by Dieter Hoffmann.
Thrombosis Research | 1995
Gerhard Dickneite; Dirk Seiffge; Karl Heinz Diehl; Martin Reers; Jörg Czech; Ernst Weinmann; Dieter Hoffmann; Werner Stüber
The new thrombin inhibitor CRC 220 was characterized in vivo for its antithrombotic effects. CRC 220 led to a dose-dependent prolongation of clotting parameters as determined in rats, rabbits, dogs, sheeps, pigs and monkeys. We evaluated the efficacy of CRC 220 to prevent thrombus formation in arteries and in the microcirculation in different animal models. In a rabbit model of tissue factor-induced coagulation activation, infusion of 0.5 mg/kg x h CRC 220 (3 hours) led to a significant prevention of fibrinogen decrease. In a rat model of lethal LPS-induced DIC CRC 220 significantly prevented the mortality rate after a 4h-infusion of 0.75 mg/kg x h. Thrombin-induced platelet aggregation in rat lungs could be prevented by the i.v. bolus injection of CRC 220. A dose of 0.3 mg/kg leads to a reduction of more than 80% of platelet deposition in the lung, significant inhibition was still observed 90 minutes after CRC 220 administration; at this time the inhibitor had already been cleared from plasma. Arterial thrombosis was induced in rabbits by squeezing and stenosis of the A. carotis. The i.v. bolus administration of CRC 220 dose-dependently prevented thrombus formation, an ED50 of 0.03 mg/kg was calculated. This dose was associated with only a minor prolongation of aPTT.
Cancer Research | 1994
Klaus Bosslet; Jörg Czech; Dieter Hoffmann
Archive | 1995
Klaus Bosslet; Jörg Czech; Dieter Hoffmann; Cenek Kolar; Fran Cedilla Ois Tillequin; Jean-Claude Florent; Michel Azoulay; Claude Monneret; Jean-Claude Jacquesy; Jean-Pierre Gesson; Michel Koch
Archive | 1994
Klaus Bosslet; Org J. Czech; Dieter Hoffmann; Andrea Vasella; Roland Hoos; Fran Cedilla Ois Tillequin; Jean-Claude Florent; Michel Azoulay; Claude Monneret; Jean-Claude Jacquesy; Jean-Pierre Gesson; Michel Koch
Archive | 1994
Volker Dr. Krone; Michael Dr. Magerstädt; Axel Walch; Albrecht Groner; Dieter Hoffmann
Archive | 1991
Volker Dr. Krone; Michael Dr. Magerstädt; Axel Walch; Albrecht Groner; Dieter Hoffmann
Archive | 1995
Klaus Bosslet; Jörg Czech; Dieter Hoffmann
Archive | 1994
Klaus Bosslet; Joerg Czech; Dieter Hoffmann; François Tillequin; Jean-Claude Florent; Michel Azoulay; Claude Monneret; Jean-Claude Jacquesy; Jean-Pierre Gesson; Michel Koch; Andrea Vasella; Roland Hoos
Archive | 1994
Klaus Bosslet; Joerg Czech; Dieter Hoffmann
Archive | 1993
Klaus Bosslet; Joerg Czech; Dieter Hoffmann; Cenek Kolar; Francois Dr Tillequin; Jean-Claude Dr Florent; Michel Dr Azoulay; Claude Prof Monneret; Jean-Claude Prof Jacquesy; Jean-Pierre Prof Gesson; Michel Prof Koch