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Joerg Czech

Aventis Pharma

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Publication

Featured researches published by Joerg Czech.

Bioorganic & Medicinal Chemistry Letters | 2003

Design, synthesis, and structure-activity relationship of a new class of amidinophenylurea-based factor VIIa inhibitors.

Otmar Klingler; Hans Matter; Manfred Schudok; S. Paul Bajaj; Joerg Czech; Martin Lorenz; Hans Peter Nestler; Herman Schreuder; Peter Wildgoose

Selective inhibition of coagulation factor VIIa has recently gained attraction as interesting approach towards antithrombotic treatment. Using parallel synthesis supported by structure-based design and X-ray crystallography, we were able to identify a novel series of amidinophenylurea derivatives with remarkable affinity for factor VIIa. The most potent compound displays a K(i) value of 23 nM for factor VIIa.

Cancer Research | 1998

Elucidation of the Mechanism Enabling Tumor Selective Prodrug Monotherapy

Klaus Bosslet; Rainer Straub; Matthias Dr Blumrich; Joerg Czech; Manfred Gerken; Bernhard Sperker; Heyo K. Kroemer; Jean-Pierre Gesson; Michel Koch; Claude Monneret

Journal of Medicinal Chemistry | 1998

Prodrugs of Anthracyclines for Use in Antibody-Directed Enzyme Prodrug Therapy

Jean-Claude Florent; Xia Dong; Sofia Mitaku; Claude Monneret; Jean-Pierre Gesson; Jean-Claude Jacquesy; Martine Mondon; Brigitte Renoux; Solo Andrianomenjanahary; Sylvie Michel; Michel Koch; François Tillequin; Manfred Gerken; Joerg Czech; Rainer Straub; Klaus Bosslet

Archive | 1994

Improved prodrugs for enzyme mediated activation

Klaus Bosslet; Joerg Czech; Dieter Hoffmann; François Tillequin; Jean-Claude Florent; Michel Azoulay; Claude Monneret; Jean-Claude Jacquesy; Jean-Pierre Gesson; Michel Koch; Andrea Vasella; Roland Hoos

Archive | 1993

Fusion proteins for prodrug activation

Mathias Gehrmann; Gerhard Seemann; Klaus Bosslet; Joerg Czech

Archive | 1994

Bifunctional glycoproteins having a modified carbohydrate complement and their use in tumor-selective therapy

Klaus Bosslet; Joerg Czech; Dieter Hoffmann

Archive | 1993

Prodrugs, their preparation and use as medicaments

Klaus Bosslet; Joerg Czech; Dieter Hoffmann; Cenek Kolar; Francois Dr Tillequin; Jean-Claude Dr Florent; Michel Dr Azoulay; Claude Prof Monneret; Jean-Claude Prof Jacquesy; Jean-Pierre Prof Gesson; Michel Prof Koch

Archive | 1992

Fusion proteins with monoclonal antibody, Linker and beta Glucuronidase for prodrug activation; preparation and use thereof

Gerhard Seemann; Klaus Bosslet; Joerg Czech; Cenek Kolar; Dieter Hoffmann; Hans-Harald Sedlacek

Archive | 1996

Cytoplasmic expression of antibodies, antibody fragments and antibody fragment fusion proteins in E. coli

Martin Opper; Klaus Bosslet; Joerg Czech

Bioorganic & Medicinal Chemistry Letters | 2004

Structure-based design of amidinophenylurea-derivatives for factor VIIa inhibition

Otmar Klingler; Hans Matter; Manfred Schudok; Monica Donghi; Joerg Czech; Martin Lorenz; Hans Peter Nestler; Hauke Szillat; Herman Schreuder

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Collaboration

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Klaus Bosslet

Schering AG

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Dieter Hoffmann

Aventis Pharma

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Gerhard Seemann

Aventis Pharma

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Cenek Kolar

Aventis Pharma

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Claude Monneret

Curie Institute

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Hans-Harald Sedlacek

Aventis Pharma

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Jean-Claude Florent

Curie Institute

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Jean-Pierre Gesson

University of Poitiers

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Manfred Gerken

University of Hamburg

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François Tillequin

Paris Descartes University

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