Dika P. Destiani

Incidence, causative drugs, and economic consequences of drug-induced SJS, TEN, and SJS–TEN overlap and potential drug–drug interactions during treatment: a retrospective analysis at an Indonesian referral hospital

Background Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are acute life-threatening adverse drug reactions (ADRs) that are commonly caused by medications. Apart from their contribution to morbidity and mortality, these diseases may also present substantial consequences on health care resources. In this study, we aimed to identify the incidence, causative drugs, and economic consequences of these serious ADRs and potential drug–drug interactions (DDIs) during treatment. Methods A retrospective study that included 150 patients diagnosed with drug-induced SJS, SJS–TEN overlap, and TEN, from 2009 to 2013 in a referral hospital in West Java Province, Indonesia, was conducted to analyze the causative drugs, cost of illness (COI) as a representation of economic consequences, and potential DDIs during treatment. Results The results showed that analgesic–antipyretic drugs were the most frequently implicated drugs. The COIs for SJS, SJS–TEN overlap, and TEN patients were 119.49, 139.21, and 162.08 US dollars per day, respectively. Furthermore, potential DDIs with several therapeutic medications and corticosteroids used to treat SJS, SJS–TEN overlap, and TEN were also identified. Conclusion This study showed that analgesic–antipyretic was the major causative drug which contributed to SJS, SJS–TEN overlap, and TEN. Furthermore, our results also showed that SJS, SJS–TEN overlap, and TEN may cause considerable financial consequences to patients.

Polypharmacy leads to increased prevalence of potentially inappropriate medication in the Indonesian geriatric population visiting primary care facilities

Background The geriatric population is particularly vulnerable to being prescribed potentially inappropriate medication (PIM); however, the prevalence of this occurrence remains poorly investigated in Indonesia. Thus in this research, we focused on investigating the prevalence and predictors of PIM among the Indonesian geriatric population in a primary health care setting. Methods A retrospective observational study was conducted in 25 primary health care facilities in Karawang District, Indonesia. The medical prescriptions of patients aged ≥60 years during January–December 2014 were documented, and the PIM was assessed based on Beers and McLeod criteria. The influence of age, sex, number of diseases, and polypharmacy toward PIM was assessed using a logistic regression model. A P-value of <0.05 defined statistical significance. Results A total of 3,819 subjects were included in the study. PIM was highly prevalent (52.2%) among the Indonesian elderly. Chlorpheniramine, mefenamic acid, ibuprofen, and nifedipine were the most commonly prescribed PIM. Polypharmacy (odds ratio: 1.2 [0.6, 2.1]) was the only factor associated with the use of PIM, while sex, age, and multiple diseases did not show significant association. Conclusion PIM is a concern in the Indonesian geriatric population. Health care professionals are encouraged to review the medications of their geriatric patients using updated safety guidelines to prevent risks associated with PIM.

Psychological Distress Induces Poor Sleep Quality: A Cross-Sectional Study of Pharmacy Students in Bandung City, Indonesia

Results: The prevalence of psychological distress was well (43.1%), mild (28.6%), moderate (20.7%), and severe (7.6%). The overall sleep quality was poor and good in 84.5% and 15.5% of the students. There was a significant association between psychological distress and poor sleep quality (p=0.006). The multivariate analysis suggested that psychological distress was a predictor of poor sleep quality (OR 1.991; 95% CI, 1.311−3.026).

Patient Care Indicator: Degenerative-Nondegenerative Patients and Compounded-Non-Compounded Prescription in One of Community Pharmacy in Bandung

Pharmacy is one of facilities for pharmacist to do a pharmaceutical care. It has been reported that 50% of patients failed to receive a treatment properly because of error in prescription and dispensing practices. Pharmacist has to be more involved in patient-oriented of pharmaceutical care. This study was conducted to evaluate pharmaceutical care in Apotek Pendidikan Universitas Padjadjaran (Unpad) Bandung from July–October in 2017, by assessing several factors in drugs dispensing using WHO patient indicators instrument. This cross-sectional study was conducted with a minimum sample size of 20 patients. The indicators that we used based on WHO assessment were average consultation time, dispensing time, percent of drugs that can be delivered, percent of labeling, and knowledge of dosage. The results showed that the average of consultation time was 99.03 s, average of dispensing time was 264 s, percentage of delivered drug was 97.18%, and 100% of correctly labeled drugs. Patients’ knowledge about their drug was only 17.07%, and consultation time varied from 10 to 370 s, compared with recommended time which is 60 s. Patients’ knowledge about dose was only 21.17%. Pharmaceutical care in Apotek Pendidikan Unpad Bandung could be assessed by WHO indicators and can be seen that patients’ knowledge of drug dose was influenced by type of disease which is degenerative and nondegenerative diseases, while time of drug administration and correct drug labeling was influenced by type of prescription of patients that is prescription of compounded medicine or non-compounded medicine. Pharmacists need to increase their service time so that patients can receive the drug quickly. Low patient’s knowledge is also expected to increase by drug information service and counseling.

CP-006 Quality of life of patients on oral anticoagulant therapy in an outpatient cardiac department of a central general hospital in bandung city

This abstract was published in error and withdrawn at the author’s request.