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Featured researches published by Dilip Dixit.


Nucleosides, Nucleotides & Nucleic Acids | 1995

STRUCTURE-ACTIVITY RELATIONSHIPS AMONG A NEW CLASS OF ANTIVIRAL HETEROSUBSTITUTED 2',3'-DIDEOXYNUCLEOSIDE ANALOGUES

Tarek S. Mansour; Haolun Jin; Wei Wang; Dilip Dixit; Colleen A. Evans; H.L.Allan Tse; Bernard Belleau; John Gillard; Elizabeth Hooker; Claire Ashman; Nick Cammack; Horacio Salomon; Antonietta R. Belmonte; Mark A. Wainberg

Abstract 3′-Oxa-4′-thiocytidine nucleoside analogues 14–17 were prepared from oxathiolanes 10 and 11, and evaluated for activity against HIV-1 and HBV in vitro. The nucleoside analogues were found to possess potent activities against HIV-1 in a panel of cell lines. Compound 16 is moderately active against HBV in 2.2.15 cells.


Nucleosides, Nucleotides & Nucleic Acids | 1983

Synthesis of 5-Substituted-1-[[2-Hydroxy-1-(hydroxymethyl)ethoxy]methyl]cytosines

Kelvin K. Ogilvie; Dilip Dixit; Bruno K. Radatus; Kendall O. Smith; Karen S. Galloway

Abstract 5-Substituted cytosine analogues of 9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]guanine (BIOLF-62) have been synthesized and tested against HSV-1.


Bioorganic & Medicinal Chemistry Letters | 1995

Synthesis of racemic 2-phosphonomethyl-1,3-dioxolane nucleoside analogues as potential antiviral agents

Krzysztof Bednarski; Dilip Dixit; Tarek S. Mansour; Susan G. Colman; Sarah M. Walcott; Clare Ashman

Abstract 2-Phosphonomethyl-1,3-dioxolane nucleosides containing appropriately linked pyrimidine and purine bases at C-4 position were prepared as biomimetic analogues of antiviral 2′,3′-dideoxynucleoside monophosphates. The key coupling intermediate 10 was prepared by a cyclocondensation of diethylacetal 6 and diol 7 followed by hydrolysis and lead tetra-acetate oxidative decarboxylation.


Archive | 1990

4-(nucleoside base)-substituted-1,3-dioxolanes useful for treatment of retroviral infections

Bernard Belleau; Dilip Dixit; Nghe Nguyen-Ba


Archive | 2006

Substituted-1, 3-oxathiolanes and substituted-1, 3-dioxolanes with antiviral properties

Bernard Belleau; Pierette Belleau; Dilip Dixit; Nghe Nguyen-Ba


Archive | 1991

4-(purinyl bases)-substituted-1,3-dioxlanes

Bernard Belleau; Dilip Dixit; Nghe Nguyen-Ba


Archive | 1998

2-Substituted-4-substituted-1,3-dioxolanes and use thereof

Bernard Belleau; Dilip Dixit; Paul Nguyen-Ba


Archive | 2002

Substituted 1,3-oxathiolanes

Dilip Dixit; Nghe Nguyen-Ba; Bernard Belleau


Archive | 2002

Synthesis of substituted 1,3-dioxolanes and substituted 1,3-oxathiolanes with antiviral properties

Bernard Belleau; Pierette Belleau; Dilip Dixit; Nghe Nguyen-Ba


European Journal of Organic Chemistry | 2015

Synthesis, Structure, and Conformational Analysis of Nucleoside Analogues Comprising Six‐Membered 1,3‐Oxathiane Sugar Rings

Hala Abou Assi; Saúl Martínez-Montero; Dilip Dixit; Zhijie Chua; D. Scott Bohle; Masad J. Damha

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