Donald Berkowitz

Malabsorption as a complication of congestive heart failure

Abstract Fat absorption by using radioactive neutral fat and fatty acid technics, has been measured in 25 patients with chronic congestive heart failure. In 56 per cent of the group definite mal-absorption was present with evidence of both a digestive as well as a primary absorptive defect. Treatment with diuretics or pancreatic supplements resulted in improved absorption. Histologic examination of the pancreas and small intestine in several of these patients demonstrated the presence of mucosal and interstitial congestion and edema which may help explain the results obtained.

ACUTE PEPTIC ULCERATION FOLLOWING CARDIAC SURGERY

Excerpt A variety of stressful stimuli when applied to a susceptible host have been recorded as provoking an ulcerative response in the gastrointestinal tract. Thus burns,1-4trauma,5-9central nervo...

Blood absorptive patterns of isotopically-labeled fat and fatty acid.

Excerpt Clinical conditions associated with abnormal lipid metabolism fall into two general categories: (1) those arising from decreased intestinal absorption, and (2) those produced by a derangeme...

SELECTIVE BLOOD LIPID REDUCTIONS BY NEWER PHARMACOLOGIC AGENTS.

Abstract Preliminary data have shown that it is possible to selectively decrease cholesterol with a bile-sequestering resin (Cholestyramine), the triglycerides with an essential phospholipid preparation (Eplid), or both with an androsterone-fatty acid mixture (Atromid). However, it must be emphasized that whether a reduction of any or all of these lipid fractions has any real therapeutic or preventive value is certainly not decided at this time and awaits a prolonged and critical follow-up period in patients being treated with these agents.

THE EFFECTS OF CHLOROPHENOXYISOBUTYRATE WITH AND WITHOUT ANDROSTERONE ON THE SERUM LIPIDS, FAT TOLERANCE, AND URIC ACID.

Abstract Chlorophenoxyisobutyrate (CPIB) with or without androsterone, is an effective lipid-lowering agent producing significant reductions in the cholesterol and triglycerides in 75 to 80 per cent of those treated. Additional favorable therapeutic results demonstrated include improvement in fat tolerance and a decrease in the uric acid, both of which are secondary to the fall in the triglyceridemia that occurs. The drug produces no side effects and toxicity has not been seen.

Practical significance of serum triglycerides and radioactive fat tolerance: Their relation to current therapy for hypercholesterolemia

Abstract 1. 1. The effects of triparanol, nicotinic acid, d-thyroxine, mytatrienediol and oxymetholone on the serum cholesterol, triglycerides and fat tolerance have been determined in a group of 90 patients with hypercholesterolemia. 2. 2. Triparanol and nicotinic acid produced a decrease in the serum cholesterol without any significant changes in the triglycerides and fat tolerance. The other agents were effective in lowering the cholesterol in over 50 per cent of the treated patients with a concomitant reduction in the triglycerides and improvement in the fat tolerance. 3. 3. It is postulated that normalization of the triglycerides and fat tolerance, in addition to the cholesterol, is a more rational pharmacologic objective to seek than one directed solely toward lowering the serum cholesterol.

RADIOACTIVE FAT ABSORPTIVE PATTERNS IN THE GERIATRIC PATIENT

Many attempts have been made in the past to incriminate the aging process in the genesis of atherosclerosis. Indeed, for a long time, based on results of anatomic studies, it was universally held that the two were inevitable companions. More recent thinking in this area has been concerned with a different approach, namely, the relation of atherosclerosis to lipid metabolism. Evidence is now rapidly accumulating which indicts some derangement thereof as a basic etiologic factor in this disease. Fat metabolism, specifically in old age, has been inadequately studied. With the present availability of radioactive fat, a new tool can now be used to investigate the problem in a simple manner. This paper reports our current experiences in a group of geriatric subjects.

A clinical evaluation of the surgical management of combined mitral and aortic stenosis

Abstract 1. 1. An evaluation of the surgical management of combined mitral and aortic stenosis is described in which the mortality and complications are analyzed and the preoperative clinical and objective findings in seventy-four patients are compared with those found three to twenty-four months after operation. 2. 2. The operative mortality has been correlated with the presence of additional valvular lesions, the age of the patient, the functional status, the size of the heart, and the presence of angina. 3. 3. Comparisons are drawn between the operative mortality for mitral and aortic commissurotomy alone and that of combined commissurotomy. 4. 4. A significant improvement is noted in the symptoms of fatigability, dyspnea, and angina. However, improvement in peripheral edema was limited. 5. 5. The improvement noted in heart size, brachial artery tracings, and electrocardiographic patterns was more limited than the alterations in the symptomatology and could not be correlated with them or with one another. 6. 6. The indications and contraindications for combined commissurotomy are outlined.

The Effects of Heparin On the Serum Triglyceride and Radioactive Fat Tolerance

a radioactive fat tolerance test in patients with coronary artery disease .12 Since then, further studies by our group,13.16 and others ’17, 18 have confirmed the fact that most patients with this condition display characteristic alterations from normal in their handling of an oral test meal of }13]-triolein, notably elevated and prolonged postprandial radioactivity blood concentrations extending over and even beyond 24 hours. The present report is concerned with the effects

MITRAL STENOSIS COMPLICATING SITUS INVERSUS: A CASE SUCCESSFULLY TREATED BY COMMISSUROTOMY

Excerpt Mitral stenosis complicating situs inversus is an uncommon finding. Since we have been able to find only one other case described in the literature,1we believe it of sufficient interest to ...