Donald F. McDonald

Cryotherapy of a heterografted human bladder tumor: Long-term observations

Summary The effect of freezing (0° to −3°C), as compared to simple cooling (10° to 15°C), of a heterografted human bladder tumor was studied. The cortisonized hamster check pouch was used for the host site. The heterografted tissue was a sterile metastatic lymph node obtained from a patient with a biopsy-proven epidermoid carcinoma of the urinary bladder. The studies showed that the tumor implant was sensitive to freezing but not to cooling. The surrounding check pouch maintained its integrity with freezing. It was concluded that the tumor studied was more sensitive to freezing than the surrounding normal tissues.